In this hot article Shang-Cheng Hung et al have devised a synthetic route to heparin oligosaccharides from cheap D-glucosamine and diacetone α-D-glucose starting materials. Heparin is a widely used anticoagulant, but homogeneous heparin oligosaccharides are difficult to obtain naturally and synthetic access is required. This article describes routes to tri-, penta- and heptasaccharides which are able to inhibit eosinophil-derived neurotoxin, a protein with ribonuclease activity that is released as part of the immune response to allergic inflammation e.g. in asthma.
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Synthesis of heparin oligosaccharides and their interaction with eosinophil-derived neurotoxin
Shang-Cheng Hung, Xin-An Lu, Jinq-Chyi Lee, Margaret Dah-Tsyr Chang, Shun-lung Fang, Tan-chi Fan, Medel Manuel L. Zulueta and Yong-Qing Zhong
DOI: 10.1039/C1OB06415K
