Organic & Biomolecular Chemistry Blog

Mario Waser et al. have designed new N-spiro quaternary ammonium salt-based catalysts from tartaric acid-derived TADDOLs.  The new catalysts catalyse the asymmetric α-alkylation of glycine Schiff bases in good yields and up to 93% ee.

Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts
Mario Waser, Katharina Gratzer, Richard Herchl and Norbert Müller
DOI: 10.1039/C1OB06573D

This article is part of a joint ChemComm & OBC web theme issue on Organocatalysis.

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M. Belén Cid et al. at the Universidad Autonoma de Madrid, Spain, have devised a simple and efficient organocatalytic approach for the synthesis of alpha-aryl cyclohexenones and cyclohexanones, leading to ee up to 96% and complete diastereoselectivity, via a Michael addition and aldol reaction as key steps.

Highly rated by the reviewers and editorial office alike, this Hot Article will be FREE to access for the next 4 weeks.

This article is also part of a joint ChemComm & OBC web theme issue on Organocatalysis.

Keep checking this page as further articles are added to the web theme issue.

An organocatalytic approach to enantiomerically enriched α-arylcyclohexenones and cyclohexanones
Sara Duce, María Jorge, Inés Alonso, José Luis García Ruano and M. Belén Cid
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB06356A, Paper
From collection Organocatalysis