Uncovering a new type of phosphoramidite prodrug, Piet Herdewijn et al. at the Katholieke Universiteit Leuven (Belgium) describe the synthesis and biological evaluation of phosphoramidate d4T derivatives against HIV. Some of the newly synthesized compounds were found to act as chain terminators for HIV-1 RT, thus inhibiting HIV-1 replication.
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Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators Shiqiong Yang, Christophe Pannecouque, Eveline Lescrinier, Anne Giraut and Piet Herdewijn
DOI: 10.1039/C1OB06214J
