The article from Ahmed M. Zaed and Andrew Sutherland reporting the first total synthesis of clavaminol A, C and H features on the front cover of Issue 23. Clavaminols are 2-amino-3-alkanols recently isolated from the Mediterranean ascidian Clavelina phlegraea (see cover) and have an unusual stereochemistry of (2R,3S). Despite this they still show some cytotoxic activity.
Total synthesis of clavaminol A, C and H
Ahmed M. Zaed and Andrew Sutherland
DOI: 10.1039/C1OB06060K
On the inside front cover is work from Michael Harmata and coworkers on the synthesis of benzothiazines for use as fluorescent sensors. The fluorescent 7-amino-2,1-benzothiazines were prepared using the palladium-catalyzed reaction of 4-amino-2-chlorobenzaldehydes with a sulfoximine or the reaction of 7-fluoro-2,1-benzothiazines with amines.
Benzothiazines in organic synthesis. Synthesis of fluorescent 7-amino-2,1-benzothiazines
Nattawut Yongpruksa, Siddharth Pandey, Gary A. Baker and Michael Harmata
DOI: 10.1039/C1OB06051A
