In this Hot article, Adam T. Slósarczyk and Lars Baltzer from Uppsala University, Sweden, report on the conjugation of designed polypeptides to a small organic molecule as a strategy for the recognition and binding of phosphorylated proteins.
Conjugating a polypeptide to the zinc chelating ligand led to a dramatic increase in affinity and selectivity towards phosphoproteins, here caseins, however this concept for binder development is thought to be widely applicable and ‘high-affinity binders can conveniently be developed for a variety of proteins including those with posttranslational modifications for which small molecule recognition elements are available.’, report the authors.
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Reference
The molecular recognition of phosphorylated proteins by designed polypeptides conjugated to a small molecule that binds phosphate
Adam T. Ślósarczyk and Lars Baltzer
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB06154B, Paper
