Sabine Schlecht and colleagues from the Free University of Berlin have designed a series of sulfated cyclic and acyclic amino alcohols bound to colloidal gold nanoparticles for use as multivalent selectin binding agents. The carbohydrate mimics were chosen to act as simplified analogs of the sLex unit found in biological selectin ligands, and demonstrated extremely high binding affinities towards L- and P-selectin and no cytotoxicity.
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Multivalent interaction and selectivities in selectin binding of functionalized gold colloids decorated with carbohydrate mimetics
Meike Roskamp, Sven Enders, Fabian Pfrengle, Shahla Yekta, Vjekoslav Dekaris, Jens Dernedde, Hans-Ulrich Reissig and Sabine Schlecht
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05583F
