Work from Asish K. Bhattacharya (National Chemical Laboratory, India) and co-workers features on the front cover of Issue 15. Their paper describes the FeCl3 catalysed four-component condensation of diamines, acetone and phosphites in the presence of molecular sieves to yield benzodiazepinyl phosphonates which demonstrate protease inhibition activity against clostripain.
An efficient synthesis of benzodiazepinyl phosphonates as clostripain inhibitors via FeCl3 catalyzed four-component reaction
Asish K. Bhattacharya, Kalpeshkumar C. Rana, Dnyaneshwar S. Raut, Vaibhav P. Mhaindarkar and Mohamad I. Khan
Org. Biomol. Chem., 2011, 9, 5407-5413
DOI: 10.1039/C0OB01102A
On the inside front cover we have work from Boris Vauzeilles (CNRS) et al. on the synthesis of neoglycoconjugates as glycosidase inhibitors through click connection of the iminosugar deoxynojirimycin and functionalised adamantanes.
Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain
Nicolas Ardes-Guisot, Dominic S. Alonzi, Gabriele Reinkensmeier, Terry D. Butters, Caroline Norez, Frédéric Becq, Yousuke Shimada, Shinpei Nakagawa, Atsushi Kato, Yves Blériot, Matthieu Sollogoub and Boris Vauzeilles
Org. Biomol. Chem., 2011, 9, 5373-5388
DOI: 10.1039/C1OB05119A
Both articles are free to access for 6 weeks, so why not take a look? You can also view the rest of the issue online here
