Cascade reactions and multiple rings – OBC emerging area

Cascade or domino processes have become one of the Holy Grails in organic synthesis. They allow the sequential formation of multiple new bonds and therefore, the one-pot synthesis of new and complex organic molecules. 

The formation of new cyclic frameworks in a controlled-one synthetic operation is almost a dream come true for synthetic chemists due to the complexity and challenging structure of these heterocycles.

In this review article, Edward Anderson, at Oxford University, gives us a selective overview of cascade reactions as applied to natural product synthesis. We invite you to download it and read this excellent accounting of recent cascade-based polycyclic reactions towards the synthesis of natural products.

Cascade polycyclisations in natural product synthesis
Edward A. Anderson
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05212H, Emerging Area

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