Cascade or domino processes have become one of the Holy Grails in organic synthesis. They allow the sequential formation of multiple new bonds and therefore, the one-pot synthesis of new and complex organic molecules.
The formation of new cyclic frameworks in a controlled-one synthetic operation is almost a dream come true for synthetic chemists due to the complexity and challenging structure of these heterocycles.
In this review article, Edward Anderson, at Oxford University, gives us a selective overview of cascade reactions as applied to natural product synthesis. We invite you to download it and read this excellent accounting of recent cascade-based polycyclic reactions towards the synthesis of natural products.
Cascade polycyclisations in natural product synthesis
Edward A. Anderson
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05212H, Emerging Area
