The effect of substituents on the thermodynamic stabilities of trisubstituted carbon-centered radicals is an interesting topic that has received limited attention in literature until now.
Now, Leo Radom and collaborators in Australia and Switzerland present in this paper a thorough computational study, which correlates with experimental data, of the stability of a very large series of multiply-substituted carbon-centered radicals. They look at the stabilization and interaction energies and the deviations from additivity of RSEs.
If you want to learn about the 14 conclusions they reach in this HOT article, download it now. It is free to access until 5th May.
This article will be included in the OBC special issue in memory of Athel Beckwith: Free Radical Chemistry. Coming soon.
Effect of substituents on the stabilities of multiply-substituted carbon-centered radicals
Ambili S. Menon, David J. Henry, Thomas Bally and Leo Radom
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C1OB05196B
