Cellular oxidative stress is thought to lie behind many disease and ageing processes, so an understanding of its effects is vital to designing strategies to counter such damage. Cynthia J. Burrows et al. from University of Utah have conducted a characterisation study of the nucleoside degradation products of copper-mediated Fenton reactions and determined the major product to be a recently discovered hydantoin, d2Ih. The products contrast with those produced in radiation-induced oxidation and the discovery of a new product, dGhred, in the double-stranded oligodeoxynucleotide studies points the way for future chemical and biological studies in this vital area.
The referees thought this was a very significant work so read this HOT article today in OBC – it is free to access until 28th April!
Characterization of 2′-deoxyguanosine oxidation products observed in the Fenton-like system Cu(II)/H2O2/reductant in nucleoside and oligodeoxynucleotide contexts
Aaron M. Fleming, James G. Muller, Insun Ji and Cynthia J. Burrows
Org. Biomol. Chem., 2011, Advance Article