HOT: Radical cyclisations made simple

Read the latest OBC hot paper in which Thorsten Bach and colleagues use a hydrogen bond template to carry out highly enantioselective radical cyclisations.

Bach’s template works as a steric shield preventing the approach of a reagent from one side of the molecule. Using the method Bach was able to demonstrate radical cyclisations of quinolines with 94–99% ee.

This is an important investigation with wide reaching consequences and will be of interest to many organic chemists. Its free to download until 21st April.   

This paper will be  included in the OBC special web themed issue on radical chemistry that will be published soon. Keep an eye on it!

Enantioselective radical cyclisation reactions of 4-substituted quinolones mediated by a chiral template
Aline Bakowski, Martina Dressel, Andreas Bauer and Thorsten Bach
Org. Biomol. Chem., 2011, DOI: 10.1039/C0OB01272F

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