Pyrano[3,2-a]carbazole alkaloids are an interesting class of molecule with pharmacological potential, which has lead to an effort to develop efficient synthetic routes towards them. Here the authors report an iron-mediated route to the pyrano[3,2-a]carbazole skeleton with high efficiencies.
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Efficient iron-mediated approach to pyrano[3,2-a]carbazole alkaloids—first total syntheses of O-methylmurrayamine A and 7-methoxymurrayacine, first asymmetric synthesis and assignment of the absolute configuration of (−)-trans-dihydroxygirinimbine
Konstanze K. Gruner, Thomas Hopfmann, Kazuhiro Matsumoto, Anne Jäger, Tsutomu Katsuki and Hans-Joachim Knölker
Org. Biomol. Chem., 2011, 9, 2057-2061
DOI: 10.1039/C0OB01088J
