HOT: Tetra-substituted furans in one pot? No problem!

When a referee calls a paper outstanding you know you are onto a good thing!
Pirali et al. from Università degli Studi del Piemonte Orientale “A. Avogadro” have documented a straightforward synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates, displaying four points of diversity and an unprecedented substitution pattern. The products are easily isolated and the functional groups are ripe for further derivatisation, making this a reaction which is both mechanistically interesting and also has practical value for synthetic and medicinal chemists.

Both reviewers thought this HOT article would be of wide interest in the organic community and it is now free to access until 18th February.

Read it today in OBC.

A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates
Riccardo Mossetti, Diego Caprioglio, Giampiero Colombano, Gian Cesare Tron and Tracey Pirali
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00979B

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