Inhibition of angiotensin converting enzyme (ACE) is generally used as one of the methods for the treatment of hypertension. ‘Oxidative stress’ is another disease state caused by an imbalance in the production of oxidants and antioxidants. Hypertension and oxidative stress may be interdependent. Therefore, ACE inhibitors having antioxidant properties are considered beneficial for the treatment of hypertension.
Bhaskar J. Bhuyan and Govindasamy Mugesh at the Indian Institute of Science in Bangalore, India, synthesise in this paper a number of selenium analogues of captopril, an ACE inhibitor used as an antihypertensive drug. These analogues not only inhibit ACE activity but also effectively scavenge peroxynitrite, a strong oxidant found in vivo.
Read this paper which is free to access until the 4th February. The referees strongly recommended it and the editorial office as well.
Synthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors Bhaskar J. Bhuyan and Govindasamy Mugesh
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00823K, Paper
