Archive for November, 2010

HOT: Rapid and clean methods of DNA ligation

Tom Brown, El-Sagheer and Cheong describe in this HOT article how oligonucleotides can be ligated into larger strands by a template-directed Diels-Alder reaction.
Maleimide and furan moieties are terminally attached to synthetic DNA oligonucleotides by Diels Alder reactions.
It is also likely that the same chemistry can be applied to biologically important RNA analogues.

Find out more in this HOT article with important applications in biology and nanotechnology which is free to access until the 14th December.

Rapid chemical ligation of oligonucleotides by the Diels–Alder reaction
Afaf H. El-Sagheer, Vee Vee Cheong and Tom Brown
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00451K
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HOT: Rate of radical clocks by Martin Newcomb

Martin Newcomb and co-workers at University of Illinois in Chicago talk about absolute kinetic studies of cyclizations of two α-hydroxy substituted radicals that can serve as radical clocks.

Read more about this  ‘excellent piece of work’ as highlighted by the referees in this HOT article that will be free to access until the 14th December.

This paper is part of a collection of papers on radical chemistry that will be published shortly in OBC. Watch out for this web themed issue coming soon.

Rate constants for cyclizations of α-hydroxy radical clocks
Christopher B. DeZutter, John H. Horner and Martin Newcomb
Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00588F

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Chiral BINOL as powerful Bronsted acid catalyst-Cover of OBC Issue 23

Svetlana B Tsogoeva and colleagues at University of Erlagen-Nuremberg review the recent advances on the most successful C-C formation reactions using chiral BINOL phosphates as Bronsted acid catalysts.

Read this review, which is free to access until the end of the year, to find out more about these very popular Bronsted acid catalysts.

Chiral BINOL-derived phosphoric acids: privileged Brønsted acid organocatalysts for C–C bond formation reactions
Alexandru Zamfir, Sebastian Schenker, Matthias Freund and Svetlana B. Tsogoeva
Org. Biomol. Chem., 2010, 8, 5262-5276
DOI: 10.1039/C0OB00209G , Perspective
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RSC journal lecture awards

While you are thinking about your nominee for the OBC Lecture Award, why not consider making nominations for other journal awards?

ChemComm Emerging Investigator Lectureship

ChemComm is delighted to invite nominations for the very first ChemComm Emerging Investigator Lectureship. The lectureship, which will be awarded annually, will recognise an emerging scientist in the early stages of their independent academic career. Deadline for nominations: 28th February 2011. Visit the ChemComm blog for more information.

Natural Product Reports Award Lecture

The NPR Lecture Award is an annual event which is held at an international meeting of the recipient’s choosing. The recipient will be someone who has made significant research contribution to natural products chemistry in its broadest sense.

Anyone can make a nomination for the award. Simply send the name of the person you would like to nominate, along with a brief justification, to the Editor, Dr Richard Kelly. All nominations should be received by Monday 6th December. Visit to NPR blog for more details.

Chem Soc Rev Emerging Investigators award

Don’t forget to nominate your colleagues for the Chem Soc Rev 2011 Emerging Investigator Award before the end of January. This annual award is given to recognise an emerging scientist who has made a significant contribution to their research field. Those wishing to make a nomination should send details of the nominee, including a brief C.V. together with a letter supporting the nomination, to the Chem Soc Rev  Editorial Office by 31st January 2011. Please note that self nomination is not permissible. More details on the CSR blog.

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