Ulrik Gether, Kristian Stromgaard and colleagues at University of Copenhagen explore the structure-activity relationships of the first small molecule inhibitor of PICK 1, a potential drug target against brain ischemia, pain and cocain addiction.
It is the inside cover of OBC Issue 19 and it will be free to access until October 19th.
Read it and try to PICK 1 comment!
Structure–activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
Anders Bach, Nicolai Stuhr-Hansen, Thor S. Thorsen, Nicolai Bork, Irina S. Moreira, Karla Frydenvang, Shahrokh Padrah, S. Brøgger Christensen, Kenneth L. Madsen, Harel Weinstein, Ulrik Gether and Kristian Strømgaard
Org. Biomol. Chem., 2010, 8, 4281-4288
DOI: 10.1039/C0OB00025F
