Natural Products Blog

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase
Hirokazu Kage, Elena Riva, James S. Parascandolo, Martin F. Kreutzer, Manuela Tosin and Markus Nett
DOI: 10.1039/C5OB02009C, Communication

The biosynthesis of allelopathic di-C-glycosylflavones from the roots of Desmodium incanum (G. Mey.) DC
Bing Hao, John C. Caulfield, Mary L. Hamilton, John A. Pickett, Charles A. O. Midega, Zeyaur R. Khan, Junru R. Wang and Antony M. Hooper
DOI: 10.1039/C5OB01926E, Paper

A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization
Shao-Rong Wang, Pedro A. Sánchez-Murcia, Federico Gago and Wei-Shuo Fang
DOI: 10.1039/C5OB02131F, Paper

Total synthesis of a piperidine alkaloid, microcosamine A
Chada Raji Reddy, Bellamkonda Latha, Kamalkishor Warudikar and Kiran Kumar Singarapu
DOI: 10.1039/C5OB02085A, Paper

The structure of tagetitoxin
Abil E. Aliev, Kersti Karu, Robin E. Mitchell and Michael J. Porter
DOI: 10.1039/C5OB02076J, Paper

Total synthesis and preliminary SAR study of (±)-merochlorins A and B
Hongzhi Yang, Xue Liu, Qingong Li, Longbo Li, Jing-Ren Zhang and Yefeng Tang
DOI: 10.1039/C5OB01946J, Paper
From themed collection 2016 Hot Articles in Organic and Biomolecular Chemistry

A method for investigating the stereochemical course of terpene cyclisations
Patrick Rabe, Jan Rinkel, Tim A. Klapschinski, Lena Barra and Jeroen S. Dickschat
DOI: 10.1039/C5OB01998B, Paper

Stereoselective total synthesis of (−)-nupharamine utilizing an α-chlorosulfide and a sulfinimine for C–C bond formation
Sadagopan Raghavan and Sheelamanthula Rajendar
DOI: 10.1039/C5OB01750E, Paper

Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia
Hua Zhang, Jia Liu, Li-She Gan, Seema Dalal, Maria B. Cassera and Jian-Min Yue
DOI: 10.1039/C5OB02296G, Paper

Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar
Marie Pascaline Rahelivao, Margit Gruner, Tilo Lübken, Daut Islamov, Olga Kataeva, Hanta Andriamanantoanina, Ingmar Bauer and Hans-Joachim Knölker
DOI: 10.1039/C5OB02280K, Paper
From themed collection 2016 Hot Articles in Organic and Biomolecular Chemistry

We hope you enjoy this selection!
Why not submit your latest natural product research to OBC today?

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Total synthesis and absolute stereochemistry of the proteasome inhibitors cystargolides A and B
Rodolfo Tello-Aburto, Liam P. Hallada, Doleshwar Niroula and Snezna Rogelj
DOI: 10.1039/C5OB01821H, Communication

Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy
Camilo F. Martinez-Farina, Nicole McCormick, Andrew W. Robertson, Helen Clement, Alison Jee, Anna Ampaw, Nei-Li Chan, Ray T. Syvitski and David L. Jakeman
DOI: 10.1039/C5OB01508A, Paper

The energetic viability of an unexpected skeletal rearrangement in cyclooctatin biosynthesis
Young J. Hong and Dean J. Tantillo
DOI: 10.1039/C5OB01785H, Communication
From themed collection 2015 Hot Articles in Organic and Biomolecular Chemistry

Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels–Alder reaction
A. R. Healy and N. J. Westwood
DOI: 10.1039/C5OB01771H, Paper

The first total synthesis of (+)-goniothalesacetate and syntheses of (+)-altholactone, (+)-gonioheptolide A, and (−)-goniofupyrone by an asymmetric acetate aldol approach
Sandeep AnkiReddy, Praveen AnkiReddy and Gowravaram Sabitha
DOI: 10.1039/C5OB01598G, Paper

4π electrocyclisation in domino processes: contemporary trends and synthetic applications towards natural products
Nadeem S. Sheikh
DOI: 10.1039/C5OB01703C, Review Article

Total synthesis of calothrixin B via sequential Sonogashira coupling/copper-catalyzed oxidative cyclization
Nagarajan Ramkumar and Rajagopal Nagarajan
DOI: 10.1039/C5OB01766A, Paper

Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis
Jeremy Just, Timothy B. Jordan, Brett Paull, Alex C. Bissember and Jason A. Smith
DOI: 10.1039/C5OB01573A, Paper

Chemoenzymatic collective synthesis of optically active hydroxyl(methyl)tetrahydronaphthalene-based bioactive terpenoids
Ramesh U. Batwal and Narshinha P. Argade
DOI: 10.1039/C5OB01740H, Paper

We hope you enjoy this selection!
Why not submit your latest natural product research to OBC today?

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

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Total synthesis of the natural product EBC-329

Raju S. Thombal and Vrushali H. Jadhav

DOI: 10.1039/C5OB01276G, Paper

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Recent developments in the chemistry of quinazolinone alkaloids

U. A. Kshirsagar

DOI: 10.1039/C5OB01379H, Review Article

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Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate

Mostafa E. Rateb, Yin Zhai, Emmanuelle Ehrner, Christopher M. Rath, Xiaoling Wang, Jioji Tabudravu, Rainer Ebel, Mervin Bibb, Kwaku Kyeremeh, Pieter C. Dorrestein, Kui Hong, Marcel Jaspars and Hai Deng

DOI: 10.1039/C5OB01269D, Paper

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Total syntheses of natural products containing spirocarbocycles

Laura K. Smith and Ian R. Baxendale

DOI: 10.1039/C5OB01524C, Review Article

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Dereplication of natural products using minimal NMR data inputs

Russell B. Williams, Mark O’Neil-Johnson, Antony J. Williams, Patrick Wheeler, Rostislav Pol and Arvin Moser

DOI: 10.1039/C5OB01713K, Comment

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Synthesis and structure–activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B

Ichiro Hayakawa, Tomomi Nakamura, Osamu Ohno, Kiyotake Suenaga and Hideo Kigoshi

DOI: 10.1039/C5OB01488C, Paper

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Racemic total synthesis of dactyloidin and demethyldactyloidin through the DL-proline-catalyzed Knoevenagel condensation/[4 + 2] cycloaddition cascade

Haibo Tan, Hongxin Liu, Xinzheng Chen, Huiyu Chen and Shengxiang Qiu

DOI: 10.1039/C5OB01636C, Paper

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Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

James McNulty, Kunal Keskar, Hilary A. Jenkins, Nick H. Werstiuk, Claudia Bordón, Robert Yolken and Lorraine Jones-Brando

DOI: 10.1039/C5OB01506E, Paper

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We hope you enjoy this selection!

Why not submit your latest natural product research to OBC today?

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a–N1′-linked pyrroloindoline alkaloids
Masanori Tayu, Takako Ishizaki, Kazuhiro Higuchi and Tomomi Kawasaki
DOI: 10.1039/C5OB00190K, Communication
From themed collection 2015 Hot Articles in Organic and Biomolecular Chemistry

Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols
Stephen J. Glynn, Kevin J. Gaffney, Marcos A. Sainz, Stan G. Louie and Nicos A. Petasis
DOI: 10.1039/C4OB02512A, Paper

Total syntheses of five uvacalols: structural validation of uvacalol A, uvacalol B and uvacalol C and disproval of the structures of uvacalol E and uvacalol G
Adiyala Vidyasagar and Kana M. Sureshan
DOI: 10.1039/C4OB02663B, Paper
From themed collection 2015 Hot Articles in Organic and Biomolecular Chemistry

Cytotoxic scalarane sesterterpenoids from the South China Sea sponge Carteriospongia foliascens
Fei Cao, Ze-Hong Wu, Chang-Lun Shao, Sen Pang, Xiao-Yan Liang, Nicole J. de Voogd and Chang-Yun Wang
DOI: 10.1039/C4OB02532F, Paper

First total synthesis of the marine natural products clavulolactones II and III
Charlotte M. Miller, Tore Benneche and Marcus A. Tius
DOI: 10.1039/C5OB00074B, Paper

Absolute configuration of remisporines A & B
Edward C. Sherer, James R. Cheeseman and R. Thomas Williamson
DOI: 10.1039/C5OB00082C, Communication

One-pot total synthesis of streptindole, arsindoline B and their congeners through tandem decarboxylative deaminative dual-coupling reaction of amino acids with indoles
Jiachen Xiang, Jungang Wang, Miao Wang, Xianggao Meng and Anxin Wu
DOI: 10.1039/C5OB00025D, Paper

Synthesis and structural reconfirmation of bacillamide B
Xue Sun, Yi Liu, Jun Liu, Guofeng Gu and Yuguo Du
DOI: 10.1039/C5OB00093A, Paper

A concise synthetic approach to brazilin via Pd-catalyzed allylic arylation
Youngeun Jung and Ikyon Kim
DOI: 10.1039/C5OB00216H, Paper

Chirality extension of an oxazine building block en route to total syntheses of (+)-hyacinthacine A2 and sphingofungin B
Seok-Hwi Park, Xiangdan Jin, Jong-Cheol Kang, Changyoung Jung, Seong-Soo Kim, Sung-Soo Kim, Kee-Young Lee and Won-Hun Ham
DOI: 10.1039/C5OB00251F, Paper

Stereoselective synthesis of the C13–C22 fragment of callystatin A by a non-aldol approach
Sadagopan Raghavan and Sheelamanthula Rajendar
DOI: 10.1039/C5OB00413F, Paper

We hope you enjoy this selection! Let us know what you think…
… and why not submit your latest natural product research to OBC today?