Natural Products Blog

Natural Products in OBC

08 Feb 2016

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

The chemical synthesis of aryltetralin glycosides
Jian-Song Sun, Hui Liu, Xiao-Hong Guo and Jin-Xi Liao
DOI: 10.1039/C5OB02188J, Review Article

Highly efficient synthesis of flavonol 5-O-glycosides with glycosyl ortho-alkynylbenzoates as donors
Jin-Xi Liao, Nai-Li Fan, Hui Liu, Yuan-Hong Tu and Jian-Song Sun
DOI: 10.1039/C5OB02313K, Communication

Trichiconlides A and B: two novel limonoids from the fruits of Trichilia connaroides
Fa-Liang An, Jun Luo, Xiao-Bing Wang, Ming-Hua Yang and Ling-Yi Kong
Journal Article Org. Biomol. Chem., 2016,14, 1231-1235
DOI: 10.1039/C5OB02300A, Communication

Synthesis of highly enantio-enriched stereoisomers of hydroxy-GR24
J. C. Morris and C. S. P. McErlean
DOI: 10.1039/C5OB02349A, Communication

Divergent synthetic route to new cyclopenta[c]pyran iridoids: syntheses of jatamanin A, F, G and J, gastrolactone and nepetalactone
Jaehoon Sim, Inah Yoon, Hwayoung Yun, Hongchan An and Young-Ger Suh
DOI: 10.1039/C5OB02147B, Paper

Total synthesis of the azolemycins
Zoe J. Anderson and David J. Fox
DOI: 10.1039/C5OB02520F, Paper

Chemoselective room temperature E1cB N–N cleavage of oxazolidinone hydrazides from enantioselective aldehyde α-hydrazination: synthesis of (+)-1,4-dideoxyallonojirimycin
Jasmin Ferreira, Sophie C. M. Rees-Jones, Valerie Ramaotsoa, Ath’enkosi Msutu and Roger Hunter
DOI: 10.1039/C5OB02560E, Communication

Marine AChE inhibitors isolated from Geodia barretti: natural compounds and their synthetic analogs
Elisabeth K. Olsen, Espen Hansen, Lindon W. K. Moodie, Johan Isaksson, Kristina Sepčić, Marija Cergolj, Johan Svenson and Jeanette H. Andersen
Journal Article Org. Biomol. Chem., 2016,14, 1629-1640
DOI: 10.1039/C5OB02416A, Paper

Total synthesis and stereochemical revision of xiamenmycin A
Xiaozhen Jiao, Yangyang Yao, Beibei Yang, Xiaoyu Liu, Xiaoyu Li, Hongguang Yang, Li Li, Jun Xu, Minjuan Xu and Ping Xie
DOI: 10.1039/C5OB02476E, Paper

Total synthesis of (±)-epithuriferic acid methyl ester via Diels–Alder reaction
Marek Koprowski, Piotr Bałczewski, Krzysztof Owsianik, Ewa Różycka-Sokołowska and Bernard Marciniak
DOI: 10.1039/C5OB02368H, Paper

Target-specific identification and characterization of the putative gene cluster for brasilinolide biosynthesis revealing the mechanistic insights and combinatorial synthetic utility of 2-deoxy-L-fucose biosynthetic enzymes
Hsien-Tai Chiu, Chien-Pao Weng, Yu-Chin Lin and Kuan-Hung Chen
DOI: 10.1039/C5OB02292D, Paper
From themed collection: 2016 Hot Articles in Organic and Biomolecular Chemistry

Solution-phase synthesis and biological evaluation of triostin A and its analogues
Kozo Hattori, Kota Koike, Kensuke Okuda, Tasuku Hirayama, Masahiro Ebihara, Mei Takenaka and Hideko Nagasawa
DOI: 10.1039/C5OB02505B, Paper

We hope you enjoy this selection!
Why not submit your latest natural product research to OBC today?

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Natural Products in OBC

05 Jan 2016

By Amy Cook.

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase
Hirokazu Kage, Elena Riva, James S. Parascandolo, Martin F. Kreutzer, Manuela Tosin and Markus Nett
DOI: 10.1039/C5OB02009C, Communication

The biosynthesis of allelopathic di-C-glycosylflavones from the roots of Desmodium incanum (G. Mey.) DC
Bing Hao, John C. Caulfield, Mary L. Hamilton, John A. Pickett, Charles A. O. Midega, Zeyaur R. Khan, Junru R. Wang and Antony M. Hooper
DOI: 10.1039/C5OB01926E, Paper

A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization
Shao-Rong Wang, Pedro A. Sánchez-Murcia, Federico Gago and Wei-Shuo Fang
DOI: 10.1039/C5OB02131F, Paper

Total synthesis of a piperidine alkaloid, microcosamine A
Chada Raji Reddy, Bellamkonda Latha, Kamalkishor Warudikar and Kiran Kumar Singarapu
DOI: 10.1039/C5OB02085A, Paper

The structure of tagetitoxin
Abil E. Aliev, Kersti Karu, Robin E. Mitchell and Michael J. Porter
DOI: 10.1039/C5OB02076J, Paper

Total synthesis and preliminary SAR study of (±)-merochlorins A and B
Hongzhi Yang, Xue Liu, Qingong Li, Longbo Li, Jing-Ren Zhang and Yefeng Tang
DOI: 10.1039/C5OB01946J, Paper
From themed collection 2016 Hot Articles in Organic and Biomolecular Chemistry

A method for investigating the stereochemical course of terpene cyclisations
Patrick Rabe, Jan Rinkel, Tim A. Klapschinski, Lena Barra and Jeroen S. Dickschat
DOI: 10.1039/C5OB01998B, Paper

Stereoselective total synthesis of (−)-nupharamine utilizing an α-chlorosulfide and a sulfinimine for C–C bond formation
Sadagopan Raghavan and Sheelamanthula Rajendar
DOI: 10.1039/C5OB01750E, Paper

Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia
Hua Zhang, Jia Liu, Li-She Gan, Seema Dalal, Maria B. Cassera and Jian-Min Yue
DOI: 10.1039/C5OB02296G, Paper

Chemical constituents of the soft corals Sinularia vanderlandi and Sinularia gravis from the coast of Madagascar
Marie Pascaline Rahelivao, Margit Gruner, Tilo Lübken, Daut Islamov, Olga Kataeva, Hanta Andriamanantoanina, Ingmar Bauer and Hans-Joachim Knölker
DOI: 10.1039/C5OB02280K, Paper
From themed collection 2016 Hot Articles in Organic and Biomolecular Chemistry

We hope you enjoy this selection!
Why not submit your latest natural product research to OBC today?

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Natural Products in OBC – our latest selection

19 Nov 2015

By Amy Cook.

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Total synthesis and absolute stereochemistry of the proteasome inhibitors cystargolides A and B
Rodolfo Tello-Aburto, Liam P. Hallada, Doleshwar Niroula and Snezna Rogelj
DOI: 10.1039/C5OB01821H, Communication

Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy
Camilo F. Martinez-Farina, Nicole McCormick, Andrew W. Robertson, Helen Clement, Alison Jee, Anna Ampaw, Nei-Li Chan, Ray T. Syvitski and David L. Jakeman
DOI: 10.1039/C5OB01508A, Paper

The energetic viability of an unexpected skeletal rearrangement in cyclooctatin biosynthesis
Young J. Hong and Dean J. Tantillo
DOI: 10.1039/C5OB01785H, Communication
From themed collection 2015 Hot Articles in Organic and Biomolecular Chemistry

Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels–Alder reaction
A. R. Healy and N. J. Westwood
DOI: 10.1039/C5OB01771H, Paper

The first total synthesis of (+)-goniothalesacetate and syntheses of (+)-altholactone, (+)-gonioheptolide A, and (−)-goniofupyrone by an asymmetric acetate aldol approach
Sandeep AnkiReddy, Praveen AnkiReddy and Gowravaram Sabitha
DOI: 10.1039/C5OB01598G, Paper

4π electrocyclisation in domino processes: contemporary trends and synthetic applications towards natural products
Nadeem S. Sheikh
DOI: 10.1039/C5OB01703C, Review Article

Total synthesis of calothrixin B via sequential Sonogashira coupling/copper-catalyzed oxidative cyclization
Nagarajan Ramkumar and Rajagopal Nagarajan
DOI: 10.1039/C5OB01766A, Paper

Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis
Jeremy Just, Timothy B. Jordan, Brett Paull, Alex C. Bissember and Jason A. Smith
DOI: 10.1039/C5OB01573A, Paper

Chemoenzymatic collective synthesis of optically active hydroxyl(methyl)tetrahydronaphthalene-based bioactive terpenoids
Ramesh U. Batwal and Narshinha P. Argade
DOI: 10.1039/C5OB01740H, Paper

We hope you enjoy this selection!
Why not submit your latest natural product research to OBC today?

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Ryan Shenvi wins 2016 NPR Emerging Investigator Lectureship

13 Nov 2015

By Michaela Mühlberg.

We are delighted to announce that Professor Ryan Shenvi from the Scripps Research Institute in San Diego (USA) is the winner of the 2016 NPR Emerging Investigator Lectureship.

The NPR Lectureship is an annual event which is held at an international meeting, the recipient being a researcher who has made a significant contribution to any natural products-related research in their early independent career.

The conference at which the lecture will be delivered will be announced in due course.

Read more on Ryan’s research on the Shenvi lab homepage.

Previous winners include:

Seth Herzon, Yale University, USA (2015 winner)
Emily Balskus, Harvard University, USA (2014 winner)
Rebecca Goss, University of St Andrews, UK (2013 winner)
Dean Tantillo, UC Davis Chemistry, USA (2012 winner)

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What are your colleagues reading in Natural Product Reports?

02 Nov 2015

By Amy Cook.

The articles below are the most read Natural Product Reports articles in July, August and September 2015.

Natural product isolation – how to get from biological material to pure compounds
Franz Bucar, Abraham Wube and Martin Schmid
DOI: 10.1039/C3NP20106F, Review Article

Natural products and Pharma 2011: Strategic changes spur new opportunities
Guy T. Carter
DOI: 10.1039/C1NP00033K, Highlight

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
DOI: 10.1039/C4NP00144C, Review Article

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms
Laura V. Flórez, Peter H. W. Biedermann, Tobias Engl and Martin Kaltenpoth
DOI: 10.1039/C5NP00010F, Review Article

Metabolomics in chemical ecology
Constanze Kuhlisch and Georg Pohnert
DOI: 10.1039/C5NP00003C, Review Article

Hot off the press
Robert A. Hill and Andrew Sutherland
DOI: 10.1039/C5NP90032H, Hot off the Press Article

Natural product and natural product derived drugs in clinical trials
Mark S. Butler, Avril A. B. Robertson and Matthew A. Cooper
DOI: 10.1039/C4NP00064A, Review Article

Mass spectrometry imaging of plant metabolites – principles and possibilities
Nanna Bjarnholt, Bin Li, Janina D’Alvise and Christian Janfelt
DOI: 10.1039/C3NP70100J, Review Article

Triterpenoids
Robert A. Hill and Joseph D. Connolly
DOI: 10.1039/C4NP00101J, Review Article

The chemistry and biological activity of the Hyacinthaceae
Dulcie A. Mulholland, Sianne L. Schwikkard and Neil R. Crouch
DOI: 10.1039/C3NP70008A, Review Article

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2016 RSC Prizes and Awards in Organic Chemistry & Chemical Biology now open for nomination

23 Oct 2015

By Michaela Mühlberg.

Nominate someone you know who is an exceptional talent in chemical sciences

The 2016 RSC Prizes and Awards are now open for nomination!

Nominations will close on 15 January 2016.

For more than 140 years, our Prizes and Awards programme has been acknowledging and celebrating exceptional talent in the chemical sciences, and with your support we are hoping that 2016 will even more successful!

Last year’s winners include Chemists such as Prof. Wilfred van der Donk (University of Illinois), Prof. Tim Donohoe (University of Oxford), Prof. Shuli You (Shanghai Institute of Organic Chemistry), Prof. Philip Gale (University of Southampton), Prof. Herman Overkleeft (Leiden University), Prof. Alison Ashcroft and Prof. Sheena Radford (University of Leeds).

This year we have 63 prizes and awards open for nominations of individuals, teams and organisations covering the breadth of the chemical sciences across academia, education and industry.

This year’s prizes in the field of Organic Chemistry & Chemical Biology include:

CBID (Chemistry Biology Interface Division) awards –

Organic Awards –

For 2016 our Longstaff Prize is also open – since 1881 we have awarded this prize once every three years to one of our members who has achieved the most to advance the science of chemistry.

Submit your suggestions now!

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Natural Products in OBC – our latest selection

05 Oct 2015

By Amy Cook.

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although signing up to OBC’s e-alert (free service) means you will receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Disulfide-bridged peptide macrobicycles from nature

Benjamin K. W. Chung and Andrei K. Yudin

DOI: 10.1039/C5OB01115A, Review Article

From themed collection 2015 Hot Articles in Organic and Biomolecular Chemistry

Total synthesis of the natural product EBC-329

Raju S. Thombal and Vrushali H. Jadhav

DOI: 10.1039/C5OB01276G, Paper

Recent developments in the chemistry of quinazolinone alkaloids

U. A. Kshirsagar

DOI: 10.1039/C5OB01379H, Review Article

Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate

Mostafa E. Rateb, Yin Zhai, Emmanuelle Ehrner, Christopher M. Rath, Xiaoling Wang, Jioji Tabudravu, Rainer Ebel, Mervin Bibb, Kwaku Kyeremeh, Pieter C. Dorrestein, Kui Hong, Marcel Jaspars and Hai Deng

DOI: 10.1039/C5OB01269D, Paper

Total syntheses of natural products containing spirocarbocycles

Laura K. Smith and Ian R. Baxendale

DOI: 10.1039/C5OB01524C, Review Article

Dereplication of natural products using minimal NMR data inputs

Russell B. Williams, Mark O’Neil-Johnson, Antony J. Williams, Patrick Wheeler, Rostislav Pol and Arvin Moser

DOI: 10.1039/C5OB01713K, Comment

Synthesis and structure–activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B

Ichiro Hayakawa, Tomomi Nakamura, Osamu Ohno, Kiyotake Suenaga and Hideo Kigoshi

DOI: 10.1039/C5OB01488C, Paper

Racemic total synthesis of dactyloidin and demethyldactyloidin through the DL-proline-catalyzed Knoevenagel condensation/[4 + 2] cycloaddition cascade

Haibo Tan, Hongxin Liu, Xinzheng Chen, Huiyu Chen and Shengxiang Qiu

DOI: 10.1039/C5OB01636C, Paper

Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

James McNulty, Kunal Keskar, Hilary A. Jenkins, Nick H. Werstiuk, Claudia Bordón, Robert Yolken and Lorraine Jones-Brando

DOI: 10.1039/C5OB01506E, Paper

We hope you enjoy this selection!

Why not submit your latest natural product research to OBC today?

Comments Off on Natural Products in OBC – our latest selection

ChemSpider for natural product research – an introduction

20 Jul 2015

By James Anson.

This blog post is an introduction to a series that we will be running that looks at how natural products research can be facilitated by new technologies, such as ChemSpider. Along the way we might also consider some of the challenges that come with generating and (re)using chemical data as we move into an age where more and more data is generated by all of us, and the end consumer of that data may not only be a human reading a publication on a screen (or in a print copy).

In our recently published editorial we mention our belief that the natural products community may benefit from both using and contributing to ChemSpider. Over the next few posts we hope to illustrate some aspects of ChemSpider that we hope may be of use.

We don’t know if you use ChemSpider every day, or have only visited the site once or twice; if you always find what you want or perhaps have sometimes have obtained unexpected results; or somewhere in-between. But we hope that we can show you how features of ChemSpider that make your life easier, be it by showing you: types of data that you didn’t know that you could find; or approaches to searching that you were not aware of. Most of all, we hope that we can show you the possibility of the resource that we as a community of researchers passionate about chemical structures can build.

Of course we don’t want this to be a one-way conversation, and we welcome comments to the blog posts and emails (please direct these to ChemSpider@rsc.org in the first instance).

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Natural Product Updates – new site launched

20 Jul 2015

By James Anson.

Natural Product Updates has launched a new website with personalised alerts, to help you to find relevant articles even faster.

On the new platform subscribers can set up tailored email alerts and saved searches, saving time and bringing the latest developments directly to their inbox.

Our trained editors select the content from a wide range of primary sources. Each article is presented with a representative structure, and is also searchable by source organism, biological activity and compound type

Natural Product Updates is a literature alerting service keeping you current with the latest developments in natural product chemistry. It covers the isolation of new natural products, structure elucidation, synthesis, biosynthesis and biological activity studies. Reviews in all of these areas are also included.

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Natural Product Reports Emerging Investigator Lectureship – nominate now!

02 Jul 2015

By Richard Kelly.

Nominations are now open for the 2016 Natural Product Reports Emerging Investigator Lectureship.

Nominate by Friday 14th August 2015

The Lectureship recognises a researcher who has made a significant contribution to a natural products-related area of the chemical sciences in their early independent career. Nominations can be made by anyone, so why not nominate a colleague, collaborator, or someone whose work you admire today?

To qualify
To be eligible for the Natural Product Reports Emerging Investigator Lectureship, the candidate should have completed their PhD on or after 31st December 2006 and have started publishing independent papers.

Lectureship details
The recipient will be invited to present a lecture at a conference during 2016. They will receive £500 towards travel and accommodation costs. They will also be presented with a certificate and be asked to contribute a Natural Product Reports article.

Nominations
Those wishing to make a nomination should send the following details to the Natural Product Reports Editorial Office by Friday 14^th August 2015:

The name, affiliation and (if possible) web address of the nominee
A paragraph outlining the reasons for nomination. This should include brief details of the nominee’s contributions to their field

Selection procedure
The Natural Product Reports Editorial Board will draw up a short-list of candidates based on the information provided at nomination. The board will then vote to select the recipient at the Autumn Editorial Board meeting, and the winner will be announced in late 2015.

Previous Winners
2013: Rebecca Goss – University of St Andrews, UK
2014: Emily Balskus – Harvard University, USA
2015: Seth Herzon – Yale University, USA

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Natural Products Blog

Natural Products in OBC

Natural Products in OBC

Natural Products in OBC – our latest selection

Ryan Shenvi wins 2016 NPR Emerging Investigator Lectureship

What are your colleagues reading in Natural Product Reports?

2016 RSC Prizes and Awards in Organic Chemistry & Chemical Biology now open for nomination

Natural Products in OBC – our latest selection

ChemSpider for natural product research – an introduction

Natural Product Updates – new site launched

Natural Product Reports Emerging Investigator Lectureship – nominate now!

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