Natural Products Blog

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

The first total synthesis of nhatrangin A
Ahmed Kamal and Saidi Reddy Vangala  
DOI: 10.1039/C3OB40252E, Paper

A stereoselective approach for the southeast segment (C1–C16) of (+)-sorangicin A
Y. Sridhar and P. Srihari
DOI: 10.1039/C3OB40985F, Paper

An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin
Sabesan Yoganathan, Ning Yin, Yong He, Michael F. Mesleh, Yu Gui Gu and Scott J. Miller  
DOI: 10.1039/C3OB40924D, Paper

Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia
Walter Balansa, Robiul Islam, Frank Fontaine, Andrew M. Piggott, Hua Zhang, Xue Xiao, Timothy I. Webb, Daniel F. Gilbert, Joseph W. Lynch and Robert J. Capon
DOI: 10.1039/C3OB40861B, Paper

Humulane-type sesquiterpenoids from Pilea cavaleriei subsp. crenata
Cang-Song Liao, Chun-Ping Tang, Sheng Yao and Yang Ye  
DOI: 10.1039/C3OB40872H, Paper

Directed studies towards the total synthesis of (+)-13-deoxytedanolide: simple and convenient synthesis of the C8–C16 fragment
Sébastien Meiries, Alexandra Bartoli, Mélanie Decostanzi, Jean-Luc Parrain and Laurent Commeiras
DOI: 10.1039/C3OB40674A, Paper

The cascade radical cyclisation approach to prenylated alkaloids: synthesis of stephacidin A and notoamide B
Nigel S. Simpkins, Ilias Pavlakos, Michael D. Weller and Louise Male
DOI: 10.1039/C3OB40979A, Paper

We hope you enjoy this selection! Let us know what you think…

… and why not submit your next natural product research to OBC ?

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Concise synthesis of (−)-steviamine and analogues and their glycosidase inhibitory activities
Nadechanok Jiangseubchatveera, Marc E. Bouillon, Boonsom Liawruangrath, Saisunee Liawruangrath, Robert J. Nash and Stephen G. Pyne
DOI: 10.1039/C3OB40374B, Paper

Synthesis of the decalin core of codinaeopsin via an intramolecular Diels–Alder reaction
Mani Ramanathan, Chun-Jui Tan, Wen-Jung Chang, Hui-Hsu Gavin Tsai and Duen-Ren Hou
DOI: 10.1039/C3OB40480C, Paper

Synthesis and antiproliferative activity of selenoindirubins and selenoindirubin-N-glycosides
Friedrich Erben, Dennis Kleeblatt, Marcel Sonneck, Martin Hein, Holger Feist, Thomas Fahrenwaldt, Christine Fischer, Abdul Matin, Jamshed Iqbal, Michael Plötz, Jürgen Eberle and Peter Langer
DOI: 10.1039/C3OB40603B, Paper

Total syntheses of oroidin, hymenidin and clathrodin
Sivappa Rasapalli, Venkatreddy Kumbam, Abasaheb N. Dhawane, James A. Golen, Carl J. Lovely and Arnold L. Rheingold
DOI: 10.1039/C3OB40668G, Communication

Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents
Kyriacos C. Nicolaou and Roman A. Valiulin
DOI: 10.1039/C3OB40654G, Paper

First studies directed towards the diastereoselective synthesis of the BCD tricyclic core of brownin F
Fabien Rodier, Jean-Luc Parrain, Gaëlle Chouraqui and Laurent Commeiras
DOI: 10.1039/C3OB40363G, Paper

Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase
Cheng-Hsiang Chang, Hao-Yu Wen, Wen-Shiang Shie, Ching-Ting Lu, Meng-Erh Li, Yuan-Ting Liu, Wen-Hsuan Li and Tung-Kung Wu
DOI: 10.1039/C3OB40493E, Paper

We hope you enjoy this selection! Let us know what you think…

… and why not submit your latest natural product research to OBC today?

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Total synthesis of (+)-pentamethylsalvianolic acid C
Benjamin L. Alford and Helmut M. Hügel
Org. Biomol. Chem., 2013,11, 2724-2727
DOI: 10.1039/C3OB27478K, Paper

Concise total syntheses of (±)-noruleine and (±)-uleine
Süleyman Patir and Erkan Ertürk
Org. Biomol. Chem., 2013,11, 2804-2810
DOI: 10.1039/C3OB40180D, Paper

A concise approach to the spiroiminal fragment of marineosins
Guang Li, Xun Zhang, Qi Li, Pengju Feng and Yian Shi
Org. Biomol. Chem., 2013,11, 2936-2938
DOI: 10.1039/C3OB40208H, Communication

Highly stereoselective directed reactions and an efficient synthesis of azafuranoses from a chiral aziridine
Hogyu Lee, Jun Hee Kim, Won Koo Lee, Jaeheung Cho, Wonwoo Nam, Jaedeok Lee and Hyun-Joon Ha
Org. Biomol. Chem., 2013,11, 3629-3634
DOI: 10.1039/C3OB27390C, Paper

We hope you enjoy this selection! Let us know what you think…

… and why not submit your latest natural product research to OBC today?

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Watsonianone A–C, anti-plasmodial β-triketones from the Australian tree, Corymbia watsoniana
Anthony R. Carroll, Vicky M. Avery, Sandra Duffy, Paul I. Forster and Gordon P. Guymer
Org. Biomol. Chem., 2013,11, 453-458
DOI: 10.1039/C2OB26931G, Paper

A mechanistic study on the Hooker oxidation: synthesis of novel indane carboxylic acid derivatives from lapachol
Kenneth O. Eyong, Manohar Puppala, Ponminor Senthil Kumar, Marc Lamshöft, Gabriel N. Folefoc, Michael Spiteller and Sundarababu Baskaran
Org. Biomol. Chem., 2013,11, 459-468
DOI: 10.1039/C2OB26737C, Paper

Synthesis of N,N′-diglycosylated isoindigos
Dennis Kleeblatt, Baraa Siyo, Martin Hein, Viktor O. Iaroshenko, Jamshed Iqbal, Alexander Villinger and Peter Langer
Org. Biomol. Chem., 2013,11, 886-895
DOI: 10.1039/C2OB25866H, Communication

First total synthesis of Debilisone C
Bishwajit Saikia, Thongam Joymati Devi and Nabin C. Barua
Org. Biomol. Chem., 2013,11, 905-913
DOI: 10.1039/C2OB26329G, Paper

Synthesis and biological studies of neopetrosiamides as inhibitors of cancer cell invasion
Kaitlyn M. Towle, Jennifer L. Chaytor, Hongqiang Liu, Pamela Austin, Michel Roberge, Calvin D. Roskelley and John C. Vederas
Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB27238A, Paper

Stereoselective syntheses of racemic quercitols and bromoquercitols starting from cyclohexa-1,4-diene: gala-, epi-, muco-, and neo-quercitol Gökay Aydın, Tahir Savran, Fatih Aktaş, Arif Baran and Metin Balci
Org. Biomol. Chem., 2013, Advance Article
DOI: 10.1039/C3OB26909D, Paper

We hope you enjoy this selection! Let us know what you think…

… and why not submit your latest natural product research to OBC today?

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

Hand-picked for you from the latest issues are:

Intramolecular nitrone dipolar cycloadditions: control of regioselectivity and synthesis of naturally-occurring spirocyclic alkaloids
Alastair J. Hodges, Joseph P. Adams, Andrew D. Bond, Andrew B. Holmes, Neil J. Press, Stephen D. Roughley, John H. Ryan, Simon Saubern, Catherine J. Smith, Michael D. Turnbull and Annabella F. Newton
DOI: 10.1039/C2OB26333E, Paper

You will have spotted in this article’s authors list Annabella Newton, who contributes to the OBC blogs as a guest web-writer. She is currently a postdoctoral researcher based in Melbourne, Australia. Why not read some of her posts here:
– One for all and all for one: shape-shifting organic molecules that spontaneously resolve
– Supramolecular chemistry: synthetic ion channels

A furan Diels–Alder cycloaddition approach to scyphostatin analogues
Calum J. Fraser, Gareth P. Howell and Joseph P. A. Harrity
DOI: 10.1039/C2OB26793D, Paper

Spiralisones A–D: acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis
Hua Zhang, Xue Xiao, Melissa M. Conte, Zeinab Khalil and Robert J. Capon
DOI: 10.1039/C2OB26988K, Paper

Total syntheses of pamamycin 607 and methyl nonactate: stereoselective cyclisation of homoallylic alcohols that had been prepared with remote stereocontrol using allylstannanes
Olivier Germay, Naresh Kumar, Christopher G. Moore and Eric J. Thomas
DOI: 10.1039/C2OB26801A, Paper

We hope you enjoy this selection! Let us know what you think…

… and why not submit your latest natural product research to OBC today?

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

Concise construction of the tetracyclic core of lycorine-type alkaloids and the formal synthesis of α-lycorane based on asymmetric bifunctional thiourea-catalyzed cascade reaction
Yao Wang, Yong-Chun Luo, Hong-Bo Zhang and Peng-Fei Xu
Org. Biomol. Chem., 2012,10, 8211-8215
DOI: 10.1039/C2OB26422F, Paper

Triterpenoids functionalized at C-2 as diagenetic transformation products of 2,3-dioxygenated triterpenoids from higher plants in buried wood
Gilles Schnell, Philippe Schaeffer, Estelle Motsch and Pierre Adam
Org. Biomol. Chem., 2012,10, 8276-8282
DOI: 10.1039/C2OB26191J, Paper

Total synthesis of noricumazole B establishes D-arabinose as glycan unit
Jenny Barbier, Klaus Gerth, Rolf Jansen and Andreas Kirschning
Org. Biomol. Chem., 2012,10, 8298-8307
DOI: 10.1039/C2OB26256H, Paper

The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs
E. Zachary Oblak, Erin S. D. Bolstad, Sophia N. Ononye, Nigel D. Priestley, M. Kyle Hadden and Dennis L. Wright
Org. Biomol. Chem., 2012,10, 8597-8604
DOI: 10.1039/C2OB26553B, Communication

Baylis–Hillman acetates in organic synthesis: convenient one-pot synthesis of α-carboline framework – a concise synthesis of neocryptolepine
Deevi Basavaiah and Daggula Mallikarjuna Reddy
Org. Biomol. Chem., 2012,10, 8774-8777
DOI: 10.1039/C2OB26339D, Communication

• Also of interest: Have you read the Natural Products themed issue of MedChemComm?

Guest edited by Professor Christopher Walsh and Dr Sylvie Garneau-Tsdodikova, the issue contains some of the newest discoveries in the field, along with 9 review articles that will lead the reader through exciting natural products research. Let us know what you think!