Author Archive

HOT: Analysing ginseng

Ginseng is one of the world’s most widely used medicinal plants and it is one of the best selling natural products nowadays. Due to its medicinal effects, ginseng has always been an attractive natural product to study and understand.   

However, one of the biggest challenges of ginseng research is the complexity of its chemical constituents and their analysis. Thus, a wide range of analytical methods need to be used to fully characterise these ‘magical components’.

In this very comprehensive review, Lian-Wen Qi, Chong-Zhi Wang and Chun-Su Yuan  illustrate the recent advances in the isolation and analysis of ginseng and highlight its new applications, especially in species authentication, quality assessment and interaction with biological systems.

It is a HOT review because it received very positive comments from the referees and the editorial office.

This will be an excellent article for new-comers in the field as well as a refreshment course for old-timers

Download it now, it’s free to access and learn more about ginseng!

Isolation and analysis of ginseng: advances and challenges
Lian-Wen Qi, Chong-Zhi Wang and Chun-Su Yuan
Nat. Prod. Rep., 2011, Advance Article
DOI: 10.1039/C0NP00057D, Review

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest natural products’ related articles in OBC Issue 3 (coming soon) have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation
Matthias G. J. Baud, Thomas Leiser, Franz-Josef Meyer-Almes and Matthew J. Fuchter
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00824A, Communication

Efficient total synthesis of (−)-stemoamide
Toshio Honda, Tomoha Matsukawa and Kazunori Takahashi
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00850H, Communication

Stereoselective synthesis of the C15–C26 fragment of the antitumor agent (−)-dictyostatin
Leticia Ferreiro-Mederos, Silvia Vila-Gisbert, Antonio Urbano, M. Carmen Carreño and Françoise Colobert
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00491J, Paper

Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale
Mahmoud Fahmi Elsebai, Stefan Kehraus, Ulrike Lindequist, Florenz Sasse, Saad Shaaban, Michael Gütschow, Michaele Josten, Hans-Georg Sahl and Gabriele M. König
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00625D, Paper

Klysimplexins I–T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex
Bo-Wei Chen, Chih-Hua Chao, Jui-Hsin Su, Chung-Wei Tsai, Wei-Hsien Wang, Zhi-Hong Wen, Chiung-Yao Huang, Ping-Jyun Sung, Yang-Chang Wu and Jyh-Horng Sheu
 Org. Biomol. Chem., 2011, Advance Article
DOI: 10.1039/C0OB00351D, Paper

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest NP articles have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Synthesis of (±)-desethylrhazinal using a tandem radical addition-cyclization process
Ehecatl Paleo, Yazmin M. Osornio and Luis D. Miranda
Org. Biomol. Chem., 2011, 9, 361-362
DOI: 10.1039/C0OB00572J, Communication

Intramolecular hydroalkoxylation in Brønsted acidic ionic liquids and its application to the synthesis of (±)-centrolobine
Yunkyung Jeong, Do-Young Kim, Yunsil Choi and Jae-Sang Ryu
Org. Biomol. Chem., 2011, 9, 374-378
DOI: 10.1039/C0OB00701C, Communication

(S)-Stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor
Takayuki Doi, Kazuaki Shibata, Masahito Yoshida, Motoki Takagi, Masayuki Tera, Kazuo Nagasawa, Kazuo Shin-ya and Takashi Takahashi
Org. Biomol. Chem., 2011, 9, 387-393
DOI: 10.1039/C0OB00513D, Paper

Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi
Anthony D. Wright, Adam McCluskey, Mark J. Robertson, Kylie A. MacGregor, Christopher P. Gordon and Jana Guenther
Org. Biomol. Chem., 2011, 9, 400-407
DOI: 10.1039/C0OB00326C, Paper

Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis
Jongtae Yang, Hui Xu, Yirong Zhang, Linquan Bai, Zixin Deng and Taifo Mahmud
Org. Biomol. Chem., 2011, 9, 438-449
DOI: 10.1039/C0OB00475H, Paper

Asymmetric total synthesis of (+)-swainsonine
Soontorn Chooprayoon, Chutima Kuhakarn, Patoomratana Tuchinda, Vichai Reutrakul and Manat Pohmakotr
Org. Biomol. Chem., 2011, 9, 531-537
DOI: 10.1039/C0OB00388C, Paper

Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni
Anthony R. Carroll, Sandra Duffy, Melissa Sykes and Vicky M. Avery
Org. Biomol. Chem., 2011, 9, 604-609
DOI: 10.1039/C0OB00538J, Paper

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What every chemist should know about plant names

NPR opens 2011 with a very interesting first issue in which a different and original viewpoint by Johannes Erkens is published:

‘In this Viewpoint, I explain why chemists should be aware of the essentials of plant naming, and describe some easy quality checks that can be performed to avoid errors being perpetuated’

This is what he says and that is exactly what he does.

You can read this article free to access until the end of January. Come on! Find out why chemists should know about plant names and comment on it.

What every chemist should know about plant names
Roy Hubertus Johannes Erkens
Nat. Prod. Rep., 2011, 28, 11-14
DOI: 10.1039/C0NP00042F

 

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Issue 1 2011 – Natural Product Reports

Our first Issue of 2011 is already here.

We are very excited about it and looking forward to making 2011 another successful year for NPR. Thank you to all our authors, readers and referees for a fantastic 2010. A big thanks goes also to the NPR Editorial Board for their support and enthusiasm.

In this first Issue you will find a brief Editorial by the new NPR Chair, Bradley Moore and the NPR Editor Richard Kelly.

This is followed by a very interesting and different viewpoint by Johannes Erkens on why chemists should be aware of the essentials of plant naming (free to access from tomorrow, 21st December, until the end of January).
Christopher Vanderwal tells us about chlorosulfolipids in the first highlight of 2011 and then we move to 6 very informative reviews.

Robert Cichewicz and Phillip Williams open this first NPR issue with two reviews on different medicinal chemistry topics. Cichewicz’s review explores the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases whereas Williams’ review looks at Alzheimer’s drug leads.

Ricardo Riguera talks about the use of NMR methods in complex mixtures and Blaine Pfeifer writes about heterologous biosynthesis as a route to access the beneficial properties of natural products.

István Molnár also looks at biosynthesis of NP; however, he focuses on the biosynthesis and biochemistry of cyclooligomer nonribosomal peptides fungal cyclooligomer depsipeptides.

This first Issue finishes with Ronald Parry‘s review on naturally occurring nitro compounds and the biosynthesis of the nitro group.

We hope you enjoy reading our first issue of 2011 and we want to wish you all a very nice New Year and the warmest Seasonal Greetings.

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Marine Natural Products Review 2011 is published!

Undoubtedly, one of the most popular NPR reviews, the marine natural products  has become a regular review everyone looks forward to.

John Blunt and his co-workers always put together a very comprehensive and detailed review with the latest literature on marine natural products.

This 2011 review highlights the literature for 2009 and describes 1011 new compounds from 352 articles, a small decrease from the number (1065) of compounds reported for 2008. As in previous reviews, the structures are shown only for new compounds, or for previously reported compounds where there has been a structural revision or a newly established stereochemistry.

You can read about all of these marine natural products in the 2011 Advance Review

Marine natural products
John W. Blunt, Brent R. Copp, Murray H. G. Munro, Peter T. Northcote and Michèle R. Prinsep
Nat. Prod. Rep., 2011, Advance Article
DOI: 10.1039/C005001F, Review

And if you missed the most recent reviews on marine natural products you have them here:

Marine natural products 2010

Marine natural products 2009

Marine natural products 2008

Marine natural products 2007

Look out for the Marine Natural Products themed issue that will be published as NPR Issue 2 in 2011.

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NPR Issue 12 – Last issue of 2010

Natural Product Reports‘ last issue of the year is now published on line.

In this issue you will be able to discover the relationship between insects and natural products, anti-influenza agents and tradicional Chinese medicine, anti-HIV and natural products, a review on the pyrrolic ring in NPs, spiridioxynaphthalenes, organic guanidine derivatives in natural products and an update on stemona alkaloids. 

All of this in a very successful 2010 last issue.

We hope you enjoy it.

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Meet the NPR team

The NPR team will be attending a number of conferences in 2011 and we would be delighted to meet you.

These are just some of the conferences where you can meet us in the coming months:

Please let us know if you are planning on attending any of these meetings as it would be lovely to meet you there.

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Highlights of NPR Issue 11

Issue 11 of Natural Product Reports is now published on line.

In this new issue, you will find interesting reviews on diterpenoids, pigments of fungi, the roles of flavones, moeromycin family antibiotics, Kdo monossacharide, indole alkaloids, sesquiterpenoids and the bioprospect for microbial antituberculosis leads.

A very diverse and informative issue on natural product reports.

I hope you like it.

Read it here.

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Natural Products in OBC

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover natural product chemistry. We will try to keep you updated, although the safest bet is for you to sign up to OBC’s e-alert (free service) and receive the table of content directly in your inbox every time an issue is published.

The latest NP articles have been collated here.

If you want to see your natural products article featured on this blog you can submit it here.

Strategies for the synthesis of bioactive pyran naphthoquinones
Vitor Francisco Ferreira, Sabrina Baptista Ferreira and Fernando de Carvalho da Silva
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00277A, Perspective

Highly efficient macrolactonization of ω-hydroxy acids using benzotriazole esters: synthesis of Sansalvamide A
José Antonio Morales-Serna, Ericka Sánchez, Ricardo Velázquez, Jorge Bernal, Eréndira García-Ríos, Rubén Gaviño, Guillermo Negrón-Silva and Jorge Cárdenas
Org. Biomol. Chem., 2010, Advance Article
DOI: 10.1039/C0OB00161A, Paper

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