Author Archive

Natural Product Reports welcomes new Advisory Members

We are delighted to welcome Professor Craig Williams (The University of Queensland), and Professor Christopher Boddy (University of Ottawa), and Dr. Sandra Loesgen (University of Florida) to the Natural Product Reports team as Advisory Board Members.

Craig Williams completed his BSc (Hons) and PhD (1997) at Flinders University of South Australia and is now Associate Professor at University of Queensland. His research is on investigating strategies towards the total synthesis of very complex natural products and designing and discovering novel biologically active molecules for use as medicines in cancer, Alzheimer’s and for pain treatments.
Sandra Loesgen is currently Associate Professor of Chemistry at the Whitney Laboratory for Marine Bioscience, and part of the Chemistry Department at University of Florida. Her research focuses on the identification and development of drug leads from the metabolic products of microbial organisms, with a special emphasis on endophytic fungi and rare actinomycetes. In particular, her research program currently focuses on the discovery of new anticancer, antimicrobial, and antiviral compounds from microbial sources.
Christopher Boddy is currently Professor at the University of Ottawa. His research is on harnessing biosynthetic pathways to produce complex molecules. His group uses synthetic chemistry and biochemistry to try to determine how microorganisms construct complex biologically active molecules and to use these biosynthetic pathways to produce complex natural products and their analogs. The goal is to develop enzyme inhibitors, study mechanisms of action, or determine structure-activity relationships.

Find some of their most recent RSC publications below:

Key achievements in the total synthesis of vibsane-type diterpenoids
Nat. Prod. Rep., 2012, 29, 440-448, DOI: 10.1039/C2NP00067A, Highlight

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Nat. Prod. Rep., 2019, 36, 35-107, DOI: 10.1039/C7NP00064B, Review Article

The clerodane ring system: investigating the viability of a direct Diels–Alder approach
Org. Biomol. Chem., 2011, 9, 4745-4747, DOI: 10.1039/C1OB05422H, Communication

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Nat. Prod. Rep., 2019, 36, 248-249, DOI: 10.1039/C8NP90041H, Correction

Pharmaceuticals that contain polycyclic hydrocarbon scaffolds
Chem. Soc. Rev., 2015, 44, 7737-7763, DOI: 10.1039/C4CS00477A, Review Article

Copper(I)-catalyzed cycloaddition of silver acetylides and azides: Incorporation of volatile acetylenes into the triazole core
Org. Biomol. Chem., 2011, 9, 6082-6088, DOI: 10.1039/C1OB05360D, Paper

EBC-318 and 339: bicyclo[10.2.1]alkanes from Croton insularis
RSC Adv., 2016, 6, 25110-25113, DOI: 10.1039/C6RA02599D, Communication

Competition between cluster fragmentation, C–C bond coupling and C–X bond activation in silver hexynyl cluster cations, [(C4H9CCAg)nAg]+. Size does matter!
Phys. Chem. Chem. Phys., 2009, 11, 4132-4135, DOI: 10.1039/B904687A, Communication

Croton insularis introduces the seco-casbane class with EBC-329 and the first casbane endoperoxide EBC-324
Chem. Commun., 2014, 50, 12315-12317, DOI: 10.1039/C4CC05413J, Communication

1,4-Diazacubane crystal structure rectified as piperazinium
Chem. Commun., 2019, 55, 11751-11753, DOI: 10.1039/C9CC06272F, Communication

N,N,N′,N′-Tetramethylenediamine dioxide (TMEDAO2) facilitates atom economical/open atmosphere Ley–Griffith (TPAP) tandem oxidation-Wittig reactions
Green Chem., 2015, 17, 4537-4540, DOI: 10.1039/C5GC01346A, Communication

Enantioselective total synthesis of (−)-neovibsanin G and (−)-14-epi-neovibsanin G
Chem. Commun., 2012, 48, 287-289, DOI: 10.1039/C1CC15995J, Communication

7-Step total synthesis of (+)-EBC-329: Photoisomerisation reveals new seco-casbane family member
Org. Biomol. Chem., 2017, 15, 7102-7105, DOI: 10.1039/C7OB01400G, Communication

N-Oxides rescue Ru(V) in catalytic Griffith–Ley (TPAP) alcohol oxidations
Chem. Commun., 2016, 52, 10301-10304, DOI: 10.1039/C6CC05440D, Communication

A concise total synthesis of (±)-cipadonoid B from synthetic azedaralide
Chem. Commun., 2011, 47, 2258-2260, DOI: 10.1039/C0CC04698A, Communication

Enantioselective synthesis of (R)-2-cubylglycine including unprecedented rhodium mediated C–H insertion of cubane
Org. Biomol. Chem., 2019, 17, 1067-1070, DOI: 10.1039/C8OB02959H, Communication

Unprecedented photochemical induced cascading rearrangement of the 3-azabicyclo[3.3.1]nonane skeleton
Org. Biomol. Chem., 2004, 2, 806-807, DOI: 10.1039/B402200A, Communication

Experimental determination of the gas phase proton affinities of the conjugate base anions of 2-iodoxybenzoic acid (IBX) and 2-iodosobenzoic acid (IBA)
Org. Biomol. Chem., 2008, 6, 2530-2533, DOI: 10.1039/B803452D, Paper

Elucidating the mechanism of the Ley–Griffith (TPAP) alcohol oxidation
Chem. Sci., 2017, 8, 8435-8442, DOI: 10.1039/C7SC04260D, Edge Article

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement
Org. Biomol. Chem., 2019, 17, 6790-6798, DOI: 10.1039/C9OB01238A, Paper

sp–sp3 Coupling reactions of alkynylsilver cations, RC[triple bond, length as m-dash]CAg2+ (R = Me and Ph) with allyliodide
Dalton Trans., 2013, 42, 9462-9467, DOI: 10.1039/C2DT32143B, Paper

Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?
Nat. Prod. Rep., 2016, 33, 183-202, DOI: 10.1039/C4NP00148F, Review Article

The role of transcription in heterologous expression of polyketides in bacterial hosts
Nat. Prod. Rep., 2013, 30, 1391-1411, DOI: 10.1039/C3NP70060G, Review Article

Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains
Org. Biomol. Chem., 2018, 16, 5771-5779, DOI: 10.1039/C8OB01512K, Paper


Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New Editorial Board Members – Natural Product Reports

We are delighted to warmly welcome three new Editorial Board Members to our Natural Product ReportsProfessor Dong-Chan Oh (Seoul National University, South Korea), and Professor Eriko Takano (University of Manchester, UK), and Professor Changsheng Zhang (South China Sea Institute of Oceanology, China Academy of Sciences, China).

Dong-Chan Oh studied oceanography and chemistry at Seoul National University, Republic of Korea. He obtained Ph. D. in marine natural products chemistry at Scripps Institution of Oceanography in 2006. After graduation, he joined Harvard Medical School as a postdoctoral research fellow and later worked as an instructor. In 2009, he started his independent academic career at Natural Products Research Institute, College of Pharmacy, Seoul National University in Korea. He conducted his research as a Howard Hughes Medical Institute International Early Career Scientist from 2012 to 2017. Dong-Chan Oh is currently a full professor of College of Pharmacy and the director of Natural Products Research Institute at Seoul National University.

His research focuses on the discovery, the structure elucidation, and the stereochemical determination of new bioactive natural products from microbes.

Eriko Takano is the Professor of Synthetic Biology in the Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, at the University of Manchester since 2012. In 2014, she was appointed as one of the three directors for the EPSRC/BBSRC-funded Manchester Synthetic Biology Research Centre, SYNBIOCHEM and in 2018, she was appointed as the deputy head of department of Chemistry. Eriko graduated from Kitasato University in Japan and did her undergraduate project with Prof Satoshi Omura (2015 Nobel Prize in Physiology and Medicine), before working at a R&D facility for a company, Meiji Seika Kaisha, for several years. After leaving industry, she obtained her PhD at the John Innes Institute, Norwich, UK, in 1994 on the regulation of antibiotic production in Streptomyces coelicolor. Before her arrival in Manchester, she had been Associate Professor at the University of Groningen, The Netherlands, and Assistant Professor (C1) at the Department of Microbiology / Biotechnology, University of Tübingen, in Germany.

Eriko is internationally recognized as a pioneer in the synthetic biology of microbes for antibiotic production. Her interests are in bioinformatics software development for designing natural products producers; untargeted metabolomics for chassis engineering in Streptomyces; secondary metabolite biosynthesis pathway assembly; and regulatory circuit engineering through signalling molecules and non-coding RNAs. Eriko has published 103 peer-reviewed papers and 4 book chapters and holds 5 patents. She is the Fellow of the Royal Society of Biology and has served as an expert advisor for the European Commission Scientific Committee on Emerging and Newly Identified Health Risks on synthetic biology, where she contributed to a series of three official Opinions with major impact on the development of the field.

Changsheng Zhang obtained a BSc. in Biology (Shanghai Jiaotong University, China, 1994) and an MSc. in Biotechnolgy (East China University of Science and Technology, 1997). In 2002, he obtained his Ph.D in Chemical Microbiology (Bergische University of Wuppertal, Germany) with Prof. Dr. W. Piepersberg. He carried out postdoctoral research on natural product glycosylation studies with J. S. Thorson at University of Wisconsin, Madison (2003-2008). In 2008, he joined the South China Sea Institute of Oceanology, China Academy of Sciences.

His research interest focuses on marine polycyclic natural product discovery and biosynthesis

You can find some of their most recent RSC publications below:

Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle
Pablo Carbonell, Andrew Currin, Adrian J. Jervis, Nicholas J. W. Rattray, Neil Swainston, Cunyu Yan, Eriko Takano and Rainer Breitling
Nat. Prod. Rep., 2016, 33, 925-932, DOI: 10.1039/C6NP00018E, Highlight

Switchable foldamer ion channels with antibacterial activity
Anna D. Peters, Stefan Borsley, Flavio della Sala, Dominic F. Cairns-Gibson, Marios Leonidou, Jonathan Clayden, George F. S. Whitehead, Iñigo J. Vitórica-Yrezábal, Eriko Takano, John Burthem, Scott L. Cockroft and Simon J. Webb
Chem. Sci., 2020, Advance Article, DOI: 10.1039/D0SC02393K, Edge Article

Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers
Zhiwen Liu, Liang Ma, Liping Zhang, Wenjun Zhang, Yiguang Zhu, Yuchan Chen, Weimin Zhang and Changsheng Zhang
Org. Biomol. Chem., 2019, 17, 1053-1057, DOI: 10.1039/C8OB02775G, Communication

Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8
Wei Liu, Vinay Gopal Jannu, Zhiwen Liu, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Wenjun Zhang, Changsheng Zhang and Yiguang Zhu
Org. Biomol. Chem., 2020, 18, 3649-3653, DOI: 10.1039/D0OB00617C, Communication

Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams
Subhasish Saha, Wenjun Zhang, Guangtao Zhang, Yiguang Zhu, Yuchan Chen, Wei Liu, Chengshan Yuan, Qingbo Zhang, Haibo Zhang, Liping Zhang, Weimin Zhang and Changsheng Zhang
Chem. Sci., 2017, 8, 1607-1612, DOI: 10.1039/C6SC03875A, Edge Article

Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019
Imran Khan, Haibo Zhang, Wei Liu, Liping Zhang, Fang Peng, Yuchan Chen, Qingbo Zhang, Guangtao Zhang, Weimin Zhang and Changsheng Zhang
RSC Adv., 2020, 10, 20738-20744, DOI: 10.1039/D0RA03529G, Paper

Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification
Qingbo Zhang, Huixian Li, Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu and Changsheng Zhang
Chem. Sci., 2017, 8, 5067-5077, DOI: 10.1039/C7SC01182B

Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis
Yiguang Zhu, Marie-Ève Picard, Qingbo Zhang, Julie Barma, Xavier Murphy Després, Xiangui Mei, Liping Zhang, Jean-Baptiste Duvignaud, Manon Couture, Weiming Zhu, Rong Shi and Changsheng Zhang
Chem. Sci., 2016, 7, 4867-4874, DOI: 10.1039/C6SC00771F, Edge Article

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)