S-Adenosylmethionine (SAM) is an enzyme cofactor involved in a wide range of enzyme-catalysed reactions. Although mainly known as a methyl donor (Nature’s methyl iodide), all parts of the molecule such as the aminocarboxylpropyl chain and nucleoside moiety are used in combination with different chemical strategies (e.g. ionic and radical reactions). This makes the diversity of accessible products, as well as different types of enzymes impressive. In addition, more and more examples are emerging where SAM is being used as a building block for natural products or other small molecules such as signalling molecules, in this rapidly developing field. Continued advances in the use and design of SAM analogues further diversify the range of products and methods related to SAM chemistry. Please enjoy the articles in the collection below.
| SAM is not the SAM(e): diastereomers of an important cofactor (Open Access)
Agnes Bartels, Philipp Germer & Jennifer N. Andexer* Nat. Prod. Reports, Advance Article |
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SAM-dependent methyltransferases: from chemoenzymatic natural product synthesis to industrial application (Open Access)
Lisa M. Böhmer, Benjamin P. Chapple, Diana A. Amariei, Martin A. Hayes & Jörg Pietruszka* Nat. Prod. Reports, Advance Article |
| S-Adenosylmethionine: considerations on its role in the origin and evolution of life (Open Access)
Andreas Kirschning* Nat. Prod. Reports, Advance Article |
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High-throughput assays for SAM-dependent methyltransferases: advances, challenges, and future perspectives (Open Access)
Renia Fotiadou, Florian Heinz, Konstantin F. G. Weigmann, Mark Doerr, Uwe T. Bornscheuer* & Ioannis V. Pavlidis* Nat. Prod. Reports, Advance Article |
| Diversity of enzymatic SAM-dependent C-methylation of aromatic compounds (Open Access)
Juliane Breiltgens & Michael Müller* Nat. Prod. Reports, Advance Article |
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Glucose 6-phosphate: the diversity of C-methylation in sugar moieties within natural product biosynthesis (Open Access)
Ziruo Zou & Michael Müller* Nat. Prod. Reports, Advance Article |
