Welcome to this special themed collection, guest edited by Mehdi Beniddir, Nadja Cech, Neha Garg and Roger Linington, dedicated to exploring the new developments that have been enabled by the application of mass spectrometry metabolomics to the natural product sciences, and to identifying both new strategies and best practices for the field. Please enjoy the articles in the collection below.
| Mass spectrometry as the unifying force in natural product sciences Mehdi A. Beniddir, Nadja B. Cech, Roger Linington & Neha Garg Nat. Prod. Rep., 2026, 43, 1070-1072 |
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Illuminating the dark space of bioactive peptides with mass spectrometry (Open Access) Nicole C. Parsley & Leslie M. Hicks* Nat. Prod. Rep., 2025, 42, 950-955 |
| Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products (Open Access) Brett C. Covington & Mohammad R. Seyedsayamdost* Nat. Prod. Rep., 2025, 42, 956-964 |
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Effective data visualization strategies in untargeted metabolomics (Open Access) Kevin Mildau*, Henry Ehlers*, Mara Meisenburg, Elena Del Pup, Robert A. Koetsier, Laura Rosina Torres Ortega, Niek F. de Jonge, Kumar Saurabh Singh, Dora Ferreira, Kgalaletso Othibeng, Fidele Tugizimana, Florian Huber & Justin J. J. van der Hooft* Nat. Prod. Rep., 2025, 42, 982-1019 |
| Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics (Open Access) Morgane Mauduit, Stéphane Greff, Marie Derrien & Charlotte Simmler* Nat. Prod. Rep., 2025, 42, 1020-1036 |
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‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes (Open Access) Robert A. Shepherd, Conrad A. Fihn, Alex J. Tabag, Shaun M. K. McKinnie & Laura M. Sanchez* Nat. Prod. Rep., 2025, 42, 1037-1054 |
| Mass spectrometry-based metabolomics approaches to interrogate host–microbiome interactions in mammalian systems (Open Access) Atharva S. Kulkarni, Guilherme M. P. Carrara, Jiangpeiyun Jin, Jarrod Laro, Thilini Peramuna, Laura-Isobel McCall* & Neha Garg* Nat. Prod. Rep., 2026, 43, 1078-1105 |
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Scalability of mass spectrometry-based metabolomics for natural extracts libraries exploration: current status, challenges, and opportunities (Open Access) Adriano Rutz*, Wout Bittremieux, Robin Schmid, Olivier Cailloux, Justin J. J. van der Hooft & Mehdi A. Beniddir* Nat. Prod. Rep., 2026, 43, 1106-1129 |
| Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches (Open Access) Eleni V. Mikropoulou, Aikaterini Basdeki & Maria Halabalaki* Nat. Prod. Rep., 2026, 43, 1130-1180 |
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Cultivar to chemotype: characterizing complex botanicals with mass spectrometry metabolomics (Open Access) Joshua J. Kellogg*, R. Teal Jordan, Madhusha M. Ranaweera, Kelsey Custer, Savannah G. Anez, Julia Bendlin, Francisco T. Chacon & Xiaoling Chen Nat. Prod. Rep., 2026, 43, 1181-1200 |
