Archive for July, 2012

Our selection of Natural Products in OBC and MedChemComm

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry.

We try to keep you updated here, although your best bet is for you to sign up to OBC’s e-alert (free service), and receive the tables of content directly in your inbox every time an issue is published.

The latest natural products’ related articles have been collated here:

Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols
Livia Gómez, Xavier Garrabou, Jesús Joglar, Jordi Bujons, Teodor Parella, Cristina Vilaplana, Pere Joan Cardona and Pere Clapés

Synthesis of the O-linked hexasaccharide containing β-D-Galf-(1→2)-β-D-Galf in Trypanosoma cruzi mucins
Gustavo A. Kashiwagi, Verónica M. Mendoza, Rosa M. de Lederkremer and Carola Gallo-Rodriguez

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist
Valentina Sepe, Raffaella Ummarino, Maria Valeria D’Auria, Gianluigi Lauro, Giuseppe Bifulco, Claudio D’Amore, Barbara Renga, Stefano Fiorucci and Angela Zampella

Synthesis and biological activity of simplified belactosin C analogues
Armin de Meijere, Vadim S. Korotkov, Alexander V. Lygin, Oleg V. Larionov, Viktor V. Sokolov, Tine Graef and Mazen Es-Sayed

Alkadienyl and alkenyl itaconic acids (ceriporic acids G and H) from the selective white-rot fungus Ceriporiopsis subvermispora: a new class of metabolites initiating ligninolytic lipid peroxidation
Hiroshi Nishimura, Midori Sasaki, Hirofumi Seike, Masaharu Nakamura and Takashi Watanabe

Asymmetric synthesis of (+)-vertine and (+)-lythrine
Laëtitia Chausset-Boissarie, Roman Àrvai, Graham R. Cumming, Laure Guénée and E. Peter Kündig

Total synthesis and structural elucidation of ent-micropyrone and (+)-ascosalipyrone
Claire Gregg and Michael V. Perkins

Have you read the Natural Products themed issue from MedChemComm? Guest edited by Professor Christopher Walsh and Dr Sylvie Garneau-Tsdodikova, the issue contains some of the newest discoveries in the field, along with 9 review articles that will lead the reader through exciting natural products research. Let us know what you think!

    

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Top ten most accessed articles in June

This month sees the following articles in Natural Product Reports that are in the top ten most accessed:

Synthetic approaches toward sesterterpenoids
Daniel T. Hog, Robert Webster and Dirk Trauner
Nat. Prod. Rep., 2012, 29, 752-779
DOI: 10.1039/C2NP20005H

Assessing calcareous sponges and their associated bacteria for the discovery of new bioactive natural products
Mélanie Roué, Elodie Quévrain, Isabelle Domart-Coulon and Marie-Lise Bourguet-Kondracki
Nat. Prod. Rep., 2012, 29, 739-751
DOI: 10.1039/C2NP20040F

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
Nat. Prod. Rep., 2012, 29, 144-222
DOI: 10.1039/C2NP00090C

Strained cyclophane natural products: Macrocyclization at its limits
Tanja Gulder and Phil S. Baran
Nat. Prod. Rep., 2012, 29, 899-934
DOI: 10.1039/C2NP20034A

Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects
Hajer Abdelkafi and Bastien Nay
Nat. Prod. Rep., 2012, 29, 845-869
DOI: 10.1039/C2NP20037F

Triterpenoids
Robert A. Hill and Joseph D. Connolly
Nat. Prod. Rep., 2012, 29, 780-818
DOI: 10.1039/C2NP20027A

Hypervalent iodine reagents in the total synthesis of natural products
Luiz F. Silva, Jr. and Berit Olofsson
Nat. Prod. Rep., 2011, 28, 1722-1754
DOI: 10.1039/C1NP00028D

Electrophilic natural products and their biological targets
Malte Gersch, Johannes Kreuzer and Stephan A. Sieber
Nat. Prod. Rep., 2012, 29, 659-682
DOI: 10.1039/C2NP20012K

Diterpenoids of terrestrial origin
James R. Hanson
Nat. Prod. Rep., 2012, 29, 890-898
DOI: 10.1039/C2NP20051A

Recent discovery of plant-derived anti-diabetic natural products
Hsin-Yi Hung, Keduo Qian, Susan L. Morris-Natschke, Chau-Shin Hsu and Kuo-Hsiung Lee
Nat. Prod. Rep., 2012, 29, 580-606
DOI: 10.1039/C2NP00074A

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Natural Product Reports? Then why not submit to us today or alternatively email us your suggestions.

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On the cover this month: The Cephalotaxus genus: a source of alkaloids and terpenoids

Welcome to Natural Product Reports Issue 8, 2012

Featuring on this month’s cover is work by Hajer Abdelkafi and Bastien Nay at the Museum National d’Histoire Naturelle (CNRS-MNHN, Paris, France) on natural products from the Cephalotaxus sp., which belongs to the Cephalotaxaceae family of conifers.

This genus has showed to provide both interesting alkaloids with anticancer potential, and original norditerpene tropones with cytotoxic activity. In this review article the authors present a phytochemical update and discuss the total synthesis of alkaloids and terpenoids in detail.

Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects
Hajer Abdelkafi and Bastien Nay
DOI: 10.1039/C2NP20037F

Why not also read in this issue:

Robert A. Hill and Andrew Sutherland’s Hot off the Press showcasing a personal selection of 32 recent papers covering current developments in bioorganic chemistry and novel natural products such as lycojaponicumin A from Lycopodium japonicum:

 

 

 

 

 

Like what you read? If you would like to contribute an article to NPR, please contact the editorial office with a proposed topic and we will be pleased to evaluate your synopsis.

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Natural Products in OBC 10th Anniversary issue

Organic & Biomolecular Chemistry, our sister journal, publishes many articles that cover a variety of natural product chemistry, and its 10th Anniversary issue is no exception!

Here is our selection of the latest Natural Products‘ related articles from OBC Anniversary issue 30:


Methylthioxylose – a jewel in the mycobacterial crown?
W. Bruce Turnbull and Susanne A. Stalford
DOI: 10.1039/C2OB25630D, Perspective

Photochemical oxazole–nitrile conversion downstream of rhizoxin biosynthesis and its impact on antimitotic activity
Kirstin Scherlach, Nicole Brendel, Keishi Ishida, Hans-Martin Dahse and Christian Hertweck
DOI: 10.1039/C2OB25250C, Communication

Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone
Liming Cao, John P. Maciejewski, Stephan Elzner, David Amantini and Peter Wipf
DOI: 10.1039/C2OB25353D, Communication

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim, Philip Maltas, Olivier Loiseleur, Julien Genovino and Christian Moessner
DOI: 10.1039/C2OB25100K, Paper

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim and Philip Maltas
DOI: 10.1039/C2OB25101A, Paper

Combined coinage metal catalysis in natural product synthesis: total synthesis of (+)-varitriol and seven analogs
Tao Sun, Carl Deutsch and Norbert Krause
DOI: 10.1039/C2OB25069A, Paper

Platinum catalyzed 7-endo cyclization of internal alkynyl amides and its application to synthesis of the caprazamycin core Chihiro Tsukano, Shinsuke Yokouchi, Anne-Lise Girard, Toshifumi Kuribayashi, Shota Sakamoto, Taro Enomoto and Yoshiji Takemoto
DOI: 10.1039/C2OB25111F, Paper

Structure, stereochemistry and synthesis of enantiopure cyclohexenone cis-diol bacterial metabolites derived from phenols
Derek R. Boyd, Narain D. Sharma, John F. Malone, Peter B. A. McIntyre, Paul J. Stevenson, Christopher C. R. Allen, Marcin Kwit and Jacek Gawronski
DOI: 10.1039/C2OB25079A, Paper

Also of interest is the Natural Products themed issue from MedChemComm, and this OBC blog featuring 10 of the best, most highly cited papers covering natural products from the past 10 years.

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ICPOC21: poster abstracts

There is still just time to submit your poster abstract to the 21st IUPAC International Conference on Physical Organic Chemistry (ICPOC 21) but don’t delay as the deadline is 13 July.

Register early for the best prices.

Why join ICPOC21?

Professor Dean Tantillo, University of California, Davis (USA) is the winner of the 2011 NPR Lecture Award and will be delivering his lecture at ICPOC 21.

The NPR Lecture Award is awarded to a researcher who has made a significant contribution to the field of natural products and who has been involved with the journal. Professor Tantillo was selected for his work in the field of enzymology.

In addition to the outstanding plenary sessions, there will be three parallel sessions over the five days comprising invited lectures and contributed talks, as well as poster sessions.

A broad range of scientists from across the whole community who share a quantitative perspective on chemistry will be there, providing an opportunity to discuss and celebrate the current status, development, and the future of physical organic chemistry.

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Top ten most accessed articles in May

This month sees the following articles in Natural Product Reports that are in the top ten most accessed:

Hot off the press
Robert A. Hill and Andrew Sutherland
Nat. Prod. Rep., 2012, 29, 617-621
DOI: 10.1039/C2NP90016E

Bacterial volatiles: the smell of small organisms
Stefan Schulz and Jeroen S. Dickschat
Nat. Prod. Rep., 2007, 24, 814-842
DOI: 10.1039/B507392H

The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites
Jennifer Guerra-Bubb, Rodney Croteau and Robert M. Williams
Nat. Prod. Rep., 2012, 29, 683-696
DOI: 10.1039/C2NP20021J

Electrophilic natural products and their biological targets
Malte Gersch, Johannes Kreuzer and Stephan A. Sieber
Nat. Prod. Rep., 2012, 29, 659-682
DOI: 10.1039/C2NP20012K

Marine natural products
John W. Blunt, Brent R. Copp, Robert A. Keyzers, Murray H. G. Munro and Michèle R. Prinsep
Nat. Prod. Rep., 2012, 29, 144-222
DOI: 10.1039/C2NP00090C

Triterpenoids
Robert A. Hill and Joseph D. Connolly
Nat. Prod. Rep., 2012, 29, 780-818
DOI: 10.1039/C2NP20027A

Recent discovery of plant-derived anti-diabetic natural products
Hsin-Yi Hung, Keduo Qian, Susan L. Morris-Natschke, Chau-Shin Hsu and Kuo-Hsiung Lee
Nat. Prod. Rep., 2012, 29, 580-606
DOI: 10.1039/C2NP00074A

Pheromones, attractants and other chemical cues of aquatic organisms and amphibians
Scott F. Cummins and John H. Bowie
Nat. Prod. Rep., 2012, 29, 642-658
DOI: 10.1039/C2NP00102K

The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus
Xiao-Long Yang, Jing-Ze Zhang and Du-Qiang Luo
Nat. Prod. Rep., 2012, 29, 622-641
DOI: 10.1039/C2NP00073C

The isoprenoid-precursor dependence of Plasmodium spp.
Jan-Ytzen van der Meer and Anna K. H. Hirsch
Nat. Prod. Rep., 2012, 29, 721-728
DOI: 10.1039/C2NP20013A

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Natural Product Reports? Then why not submit to us today or alternatively email us your suggestions.

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