Welcome to NPR issue 3, 2012!
This month’s cover features the work of Kurt Faber et al. at the University of Graz, Austria, with a review on the enzyme-initiated cascade reactions for the ring formation of cyclic terpenoids and polyethers. The authors provide a mechanistic analysis of enzymatic cascade reactions leading to biomimetic strategies for natural product synthesis.
- Electrophilic and nucleophilic enzymatic cascade reactions in biosynthesis
Barbara T. Ueberbacher , Mélanie Hall and Kurt Faber
Also in the issue, read Clay C. C. Wang‘s review article on the impact of whole genome sequencing on Aspergillus secondary metabolite research:
- Advances in Aspergillus secondary metabolite research in the post-genomic era
James F. Sanchez , Amber D. Somoza , Nancy P. Keller and Clay C. C. Wang
Pedro N. Leão and coworkers provide insights into the chemical ecology of cyanobacteria, highlighting both evolutionary and chemotaxonomical studies:
- The chemical ecology of cyanobacteria
Pedro N. Leão, Niclas Engene, Agostinho Antunes, William H. Gerwick and Vitor Vasconcelos
Qingsong Liu et al. review the history of several classes of natural products as kinase inhibitors, analyzing their structural binding information and highlighting their therapeutic development potential:
- Natural products as kinase inhibitors
Jing Liu, Yi Hu, David L. Waller, Junfeng Wang and Qingsong Liu
Why not also read on the didemnin family of marine depsipeptides in this review article by Madeleine M. Joullié et al.. The authors highlight the long-standing study of didemnins and its critical application towards the understanding of the molecular mechanism of action of tamandarins and their potential use as therapeutic agents:
- Didemnins, tamandarins and related natural products
Jisun Lee, Judith N. Currano, Patrick J. Carroll and Madeleine M. Joullié
We hope that you enjoy this issue!
