Author Archive

Highlights of the 8th International Dendrimer Symposium

The 8th International Dendrimer Symposium was successfully held in Madrid on June 23–27 with Prof. Maria Angeles Muñoz-Fernandez as the chair. More than 200 scientists from all over the world participated in IDS-8 to present their latest achievements in dendrimer science.

The meeting opened with the “Ramon Areces” welcome lecture delivered by Prof. Virgil Percec, who depicted a fascinating material genome approach to construct complex dendrimer systems. Using dendritic motifs to create different types of fractal patterns was nicely exemplified by Prof. George Newkome, whereas capitalization on new strategies for dendrimer synthesis was the main focus in the lecture of Prof. René Roy. Prof. Dieter Schlüter reported the synthesis and characterization as well as discontinuities in dendronized polymers, whereas Dr. Anil Patri presented lessons learned from preclinical assessment of dendrimers.

Prof. Donald Tomalia gave a vivid and brief overview on the development of dendrimer science and focused in particular on the dendritic effects, which were further discussed in the lectures of Dr. Anne-Marie Caminade and Dr. Takuzo Aida. The meeting ended with the closing lecture of Dr. Jean-Pierre Majoral, who discussed the dendrimer space in nanomedicine and foresaw a bright future for dendrimers in therapeutic applications.

Poster prizes provided by several sponsors, including NJC, were awarded just before this closing lecture. The NJC laureats were profiled in an earlier post.

It is to note that, beside the excellent scientific program, there was a fantastic social program with a visit of the Prado museum and the Real Madrid stadium as well as the flamenco gala evening.

The next IDS meeting will be hosted by René Roy in Montreal, Canada in 2015. NJC will be there and we look forward to another excellent conference in the fascinating field of dendrimers.

Snapshots from the conference (courtesy of the organizers), including at far left the opening lecture by Virgil Percec (photo courtesy of Don Tomalia).

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Three young chemists honoured at the 8th International Dendrimer Symposium

New Journal of Chemistry sponsored 3 poster prizes at the 8th International Dendrimer Symposium that took place this summer in Madrid, continuing its support of this series of symposia and the dendrimer community in general.

Guang Zhang is a 2nd year Ph.D. student in the group of Klaus Müllen at the MPI for Polymer Research in Mainz, Germany. He is conducting research on polyphenylene dendrimers and their applications for fluorescent blue light emitting diodes. Zhang’s poster reported G1 and G2 dendrimers having triphenylamine on the surface and pyrene in the core, which showed promising properties as blue OLED materials. Guang’s reaction to winning the NJC Poster Prize: “It is a great honor for me to receive the prize. It’s also a big surprise that I can have access to NJC for free for one year.”

Surface Functionalized Polyphenylene Dendrimers for Deep Blue Light  Emitting Diodes
G. Zhang, M. Baumgarten, R. Trattnig, M. Auer, E. J. W. List, K. Müllen

The winner from Spain is Javier Sánchez, who currently is a postdoctoral fellow at the Instituto de Investigación Sanitaria Gregorio Marañón, where he also carried out his Ph.D. research in the group of María Ángeles Muñoz Fernández.  The focus of Javier’s research is anti-HIV activity, but always with an eye to the potential clinical applications. He explains: “I always try to elucidate the mechanisms by which the different dendrimers behave as they do on the HIV-1 cycle.” The research presented at the conference looked at the anti-HIV activity of different carbosilane dendrimers. After development of the dendrimers they were tested using toxicity assays, inflammatory cytokines induction, HIV infection and cell phenotyping by flow cytommetry. This has led to a dendrimer that as a microbicide has anti-HIV activity for different HIV viral strains.

Anti-HIV Activity of Thiol-Ene Carbosilane Dendrimers and Potential Topical Microbicide
J. Sánchez-Rodríguez, L. Díaz, M. Galán, M. Maly, R. Gómez, F. J. de la Mata, J. L. Jiménez, M. A. Muñoz- Fernández

The 3rd winner is from the group of Eric Simanek at Texas Christian University in the USA. Changsuk Lee is now a postdoctoral fellow, after having obtained his Ph.D. under the direction of Daniel Romo at Texas A&M University in 2010. Changsuk works towards the development of drug delivery vehicles by using various sizes and shapes of dendrimers; to date triazine dendrimers are the best delivery vehicles among others tested. The winning poster covered the synthesis of a prodrug platform with paclitaxel, its biodistribution, mice efficacy testing, and molecular dynamic simulations.

Synthesis and Biological Assessment of a Triazine Dendrimer with 16 Paclitaxel Groups
C. Lee, S.-T. Lo, J. Lim, V. C. P. da Costa, S. Ramezani, G. M. Pavan, O. Annuziata, X. Sun, E. E. Simanek

Congratulations to all 3 winners, who received a certificate, RSC book and a one-year NJC subscription.

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Your Vacation Reading from NJC

The August issue of New Journal of Chemistry contains 50 articles for your summer reading enjoyment.

Bi-polar states of solid matter.

Among the highlights of this issue, don’t miss the latest Focus review, by the group of Jürg Hulliger at the University of Bern in Switzerland. Using condensed matter theory, the key message that molecular solids can end up in bi-polar states has implications for tissue formation, function and repair. This is an interesting example of how findings in one field might lead to breakthroughs in a very different field.

A stochastic principle behind polar properties of condensed molecular matter by Jürg Hulliger, Thomas Wüst, Khadidja Brahimi, Matthias Burgener and Hanane Aboulfadl, New J. Chem., 2013, 37, 2229-2235. DOI: 10.1039/C3NJ40935J

Cover for the work of Mikata et al.

The outside and inside front covers feature highly ranked works. This month the striking outside front cover was proposed by the group of Yuji Mikata from Nara Women’s University in Japan. They achieved OFF-ON, ratiometric or ON-OFF responses towards mercury and iron cations by modifying the substitution pattern on their basic molecular skeleton.

Thioether-tethered bisquinoline derivatives as fluorescent probes for mercury(II) and iron(III) ions by Yuji Mikata, Fumie Nakagaki and Kaori Nakanishi, New J. Chem., 2013, 37, 2236-2240. DOI: 10.1039/C3NJ00233K

Cover for the work of Andruh and collaborators.

A collaborative effort by several groups in Romania and France is featured on the inside front cover. They determined the crystal structures and studied the magnetic and photophysical properties of sixteen 3d–4f Schiff-base complexes. The interaction between the two metal ions lead to interesting effects on the properties.

A new synthetic route towards binuclear 3d–4f complexes, using non-compartmental ligands derived from o-vanillin. Syntheses, crystal structures, magnetic and luminescent properties by Masood Sarwar, Augustin M. Madalan, Carmen Tiseanu, Ghenadie Novitchi, Catalin Maxim, Gabriela Marinescu, Dominique Luneau and Marius Andruh, New J. Chem., 2013, 37, 2280-2292. DOI: 10.1039/C3NJ00199G

Stay abreast of the latest research with NJC! Sign up for the free E-Alert to get the table of contents in your mailbox each month.

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Meet Our Authors from the July 2013 issue of NJC

Professor at the University of Milan

Angelo enjoying a hearty meal.

Our first featured author is (retired) Professor Angelo Gavezzotti of the University of Milan (Italy), working in the broad area of the physical chemistry of solid state materials.

Angelo is no stranger to NJC; after publishing several articles in the first years of the journal, when it was still known as Nouveau Journal de Chimie, he has recently returned as an author. In his article published in the July issue, he goes from static crystallography to the evolution and dynamics in organic crystals studied by computer simulation. This 5-year project included force field development and the writing of a new Monte Carlo simulation code, both of which had to be calibrated to organic crystals. The application of an order parameter bias to the MC code allowed it to be used to study dynamics and crystallisation.

Angelo Gavezzotti's favorite place

Angelo's favorite place in the Trentino

Equilibrium structure and dynamics of organic crystals by Monte Carlo simulation: critical assessment of force fields and comparison with static packing analysis” by Angelo Gavezzotti, New J. Chem., 2013, 37, 2110-2119. DOI: 10.1039/C3NJ00181D

To show us his favourite place on earth, Angelo didn’t look far: it is the Rifugio Larcher al Cevedale in the Trentino region of Italy.

Professor at Lorestan University

Mohsen Adeli

Our next guest is Professor Mohsen Adeli, who is in the chemistry department of Lorestan University in Khoramabad (Iran). His research deals with the organic chemistry and synthesis of nano materials applied to nanomedecine.

In his NJC Letter, short carbon nanotubes have been connected together using dendritic copolymers to produce very long and flexible CNTs. This process seems to be a promising strategy to avoid the fibrosis-like hazards of carbon nanotubes

Preparation of long supramolecular carbon nanotubes” by Mohsen Adeli, Ebrahim Mehdipour and Siamak Beyranvand, New J. Chem., 2013, 37, 1871-1873. DOI: 10.1039/C3NJ41156G

Our last author is Verónica Paredes-Garcia, who is in the Chemical Sciences Department of the University Andres Bello in Santiago (Chile). Her research activities are focused on the synthesis, structural and magnetic characterization of polymetallic systems based on carboxylate ligands and transition metal ions, with a recent emphasis on polyfunctional 3d-4f inorganic materials.

The contribution from the research group in which Verónica works correlates the structural characteristics and magnetic properties of an iron 3D network compound, showing the contribution of basic science to the design of new metal-containing materials. The research was motivated by the fact that solvothermal synthesis allows materials with new and fascinating topologies and novel properties to be obtained.

Professor at the University Andres Bello

Véronica on a recent trip to Easter Island

Structural and magnetic characterization of the tridimensional network [Fe(HCO2 )3]n·nHCO2H” by Verónica Paredes-García, Ignacio Rojas, Rosa Madrid, Andres Vega, Efrén Navarro-Moratalla, Walter Cañón-Mancisidor, Evgenia Spodine and Diego Venegas-Yazigi. New J. Chem., 2013, 37, 2120-2127. DOI: 10.1039/C3NJ00023K

Verónica likes to travel all over the world: she qualifies Isla de Pascua (Easter Island) as an amazing place that merits a visit.

Thanks to Véronica, Mohsen and Angelo for taking a few minutes to talk about themselves and their work!

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NJC Poster Prizes for Synthetic Organic Chemistry

Synthetic organic chemistry is the common theme of the research projects that were awarded NJC poster prizes at 3 regional meetings held this past spring.

Irene accepts her NJC poster prize presented by Prof. Elisabet Dunach.

Ms Justine Giauffret & Dr Irene Notar-Francesco (in the group of Sylvain Antoniotti at the Institute of Chemistry in Nice) shared the first prize for their work on the tandem cyclosimerisation and thioacylation of 1,6-enynes catalysed by supported noble metal nanoparticles. This poster was presented at the PACA region (southeastern France) meeting of the French Chemical Society (SCF) in April.

The unexpected product obtained by Justine and Irene.

 

Nathalie, winner of the NJC poster Prize.

A month later, on the other side of France in Brittany, Ms Nathalie Camus was awarded the NJC poster prize at the northwestern France regional meeting of the SCF. Nathalie is a doctoral student in the group of Raphael Tripier at the Université de Bretagne Occidentale; her poster presented the C-functionalisation of cyclams to make bifunctional chelating ligands for use in nuclear medicine.

Design of the bifunctional chelating cyclam.

 

Prof. Erick Carreira presents Alexandre with his NJC poster prize.

Moving back to the southeast to Grenoble, Mr Alexandre Cannillo was the NJC poster prize winner at the 3rd Francophone Symposium on Total Synthesis. His award-winning work used domino Petasis Diels-Alder reactions to synthesise enantiopure polycyclic compounds. Alexandre is a graduate student at the Institute on the Chemistry of Natural Substances in Gif-sur-Yvette, working under the direction of Jean-Marie Beau and Stéphanie Norsikian.

Polycyclic compounds synthesised from readily available starting materials by domino reactions.

 

Congratulations to all of our winners! We wish them continuing success with their research projects and a bright future in chemistry.

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NJC at the 96th Canadian Chemistry Conference in Quebec City

Clockwise from upper left: Place Royale, St Louis gate, Chateau Frontignac, old city signs, statue of S Champlain, St Louis street. (Photos by D Parent.)

After the wilderness of Georgian Bay, I was off to discover the old world charm of Quebec City, host of the 96th Canadian Chemistry Conference.

NJC sponsored two of the symposia included in the programming:
— “Novel Aromatic Compounds: Molecular Materials and Devices” organised by Graham Bodwell and Yuming Zhao (both at Memorial University of Newfoundland)
— “Recent Developments in Pincer Chemistry and Multidentate Ligands” organised by Davit Zargarian (University of Montreal), Hairong Guan (University of Cincinnati ) and Dmitiri Gousev (Wilfrid Laurier University )

For inorganic chemists the “place to be” at CCC was the pincer ligands symposium during the 3 days that it was held. It was SRO (“standing room only”) at times, as people came to hear some of the top experts speak, people like Gerard van Koten, Bob Crabtree, Mike Fryzuk, Alan Goldman, Dan Mindiola and Oleg Ozerov, who were the plenary lecturers

The novel aromatic compounds symposium had the feeling of a family reunion—convivial with a faithful crowd in attendance. The topics ranged from synthesis to properties to applications with plenary speakers Remi Chauvin, Ben King, Rik Tykwinski, Thomas Baumgartner, Alex Adronov, Will Skene and Dmitri Perepichka.

Novel Aromatic Compounds speakers' dinner with NJC editor Denise Parent and CCC Scientific Chair Thierry Ollevier.

At the end of each symposium, NJC hosted the speakers’ dinner with the organisers. Chic French cuisine was served up for the organic group, while the inorganic chemists were treated to hearty Quebecois cooking. It looks like everyone had a good time, enjoying the food and the company.

Next year’s meeting will be held in Vancouver from June 1–5. I for one certainly look forward to attending.

Photos from the Pincer Ligands speakers' dinner hosted by NJC. (Photos courtesy of G Wilson.)

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NJC’s special China issue is now published!

The June issue of NJC, which explores chemistry in China today, follows up on the NJC Editorial Board’s visit to Hong Kong, Shanghai and Beijing last year.

 This issue includes 3 Perspective reviews and 24 original research papers, covering a wide range of topics in chemistry, as befits the broad scope of New Journal of Chemistry.

The Perspectives review progress in the areas of:
* fluorescent chemosensors based on fluorenes (by the groups of Ping Lu and Yanguang Wang of Zhejiang University);
* hydroxylation of benzene using molecular sieve-based catalysts (by the groups of Tao Jiang and Buxing Han at the IC-CAS in Beijing);
* blue phosphorescent dyes for OLEDs (by the groups of Cheuk-Lam Ho and Wai-Yeung Wong at Hong Kong Baptist University).

“Fluorescent chemosensors based on 9-cycloheptatrienylidene fluorenes (9-CHFs)” by Binbin Hu, Ping Lu and Yanguang Wang, New J. Chem., 2013, 37, 1645-1653. DOI: 10.1039/C2NJ41063J
“Catalytic hydroxylation of benzene to phenol with hydrogen peroxide using catalysts based on molecular sieves” by Tao Jiang, Weitao Wang and Buxing Han, New J. Chem., 2013, 37, 1654-1664. DOI: 10.1039/C3NJ41163J
“Small-molecular blue phosphorescent dyes for organic light-emitting devices” by Cheuk-Lam Ho and Wai-Yeung Wong, New J. Chem., 2013, 37, 1665-1683. DOI: 10.1039/C3NJ00170A

The work of two other groups is featured on the covers:
* polypyridine complexes as sensors for nitric oxide (a contribution from the group of Kenneth Kam-Wing Lo at City University of Hong Kong) are presented on the outside front cover in a depiction of the traditional fire dragon dance;
* naphthalene diimides for organic n-type semiconductors (work done by the group of Deqing Zhang at the IC-CAS in Beijing) are highlighted the inside front cover.

“Rhenium(I) polypyridine complexes functionalized with a diaminoaromatic moiety as phosphorescent sensors for nitric oxide” by Alex Wing-Tat Choi, Che-Shan Poon, Hua-Wei Liu, Heung-Kiu Cheng and Kenneth Kam-Wing Lo, New J. Chem., 2013, 37, 1711-1719. DOI: 10.1039/C3NJ00033H
“New core-expanded naphthalene diimides with different functional groups for air-stable solution-processed organic n-type semiconductors” by Xin Chen, Jianguo Wang, Guanxin Zhang, Zitong Liu, Wei Xu and Deqing Zhang, New J. Chem., 2013, 37, 1720-1727. DOI: 10.1039/C3NJ00050H

We are very thankful to the three guest editors (Vivian W.W. Yam, Xuhong Qian and Jiannian Yao) who organised this issue, and to all of the authors who submitted their papers for inclusion in this themed issue.

 

We sincerely hope that you enjoy reading this issue—let us know what you think of it!

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Georgian Bay Day at Killbear Park

After 3 full days, Martin Stillman offered participants in CanBIC-4 a day of R&R in Killbear Provincial Park. Boarding a big yellow school bus (it’s been over 40 years since I last rode one in high school!) we were taken to the park, where we split into 2 groups. I’d opted for the “kayak in the afternoon” group (we’ll see later how that worked out) so my group started the morning with a talk on snakes.

An Eastern Foxsnake found in Ontario

Jimmy, a domesticated Eastern Foxsnake

The star of this “show-and-tell” presentation was undoubtedly Jimmy, an Eastern Foxsnake, which is an endangered species. Jimmy was illegally taken from his natural home to live in an apartment, during which time he became thoroughly domesticated. Jimmy has now lived in the park’s visitor centre for 11 years and he loves to be handled by visitors.

 

Jimmy, an Eastern Foxsnake

Jimmy enjoying a snuggle!

View along Georgian Bay at Killbear park.

Our group then headed out for a walk along the Georgian Bay shore to learn all about lichens. Our guide Jessica had done extensive research to prepare for our learned group. While Jessica pointed out various species of lichens, she told us many interesting facts about them: the symbiotic relationship (or not?) between a fungus and a photosynthetic parter (green algae or cyanobacterium); their classification and distribution; modes of reproduction; their chemistry and finally applications, such as dyes.

For me the most provocative fact was that 3 species of lichens are able to degrade the toxic form of prions, which normally are very resistant to degradation. Yes, lichens have prions, though since they have no central nervous system they are not subject to the diseases that prions can cause. So why would some specific lichens be able to degrade toxic prions?

Some leafy lichens

 

Very bright green lichens!

 

Strange black lichens

Kayaking on Georgian Bay

The morning group kayaking on Georgian Bay.

After a picnic on the beach, it was my group’s turn to go out kayaking on the bay, in tandem boats (excuse me, kayaks!). After a quick tutorial on how to put on the “skirt” that seals you into the kayak (our first challenge), how to paddle, and the responsibilities of each team member (brawn in the front, brains in the back—of course I was in the back for lack of the former), we set off for some exercise.

And exercise it was! Many of us had opted to kayak in the afternoon, thinking it would be warmer and indeed it was. However, the wind had come up in the early afternoon, leading to choppy water and a much harder row for those of us out there. We didn’t make it as far as the morning group, and on our way back, against the wind, the shore seemed to remain out of reach, until we finally arrived. And that is when it happened—trying to get out of the kayak I didn’t coordinate very well with my partner and ended up “sitting down” in the water. Yikes!

Finally, some relaxation: time for a BBQ and convivial talk to end the day, before returning to Parry Sound.

If there’s one word that characterises Martin, it has to be energy—boundless energy—and one needs plenty of it to keep up with him, even in fun!

A view of Georgian Bay at Killbear Park Myself on the rocky shore of Georgian Bay Killbear Park shore

All photos copyright Denise Parent

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NJC at CanBIC-4 in Ontario

Stockey Centre for the Performing Arts in Parry Sound

Stockey Centre for the Performing Arts in Parry Sound, location for the CanBIC conferences

I arrived in Parry Sound on Georgian Bay, after flying into Toronto and taking a long bus ride up north, to promote NJC at the 4th Georgian Bay International Conference on Bioinorganic Chemistry. NJC was a major sponsor this year, providing support for the student volunteers who are “on call” to ensure that the conference runs smoothly.

This year’s event brought together about 140 scientists: about two-thirds from North America with the other participants being mainly from Europe and Japan.

This is not a conference for the weak-of-heart: the conference organisers (Martin Stillman, Nagao Kobayashi, C Frank Shaw III) put together a very full and challenging program combining science and fun in a beautiful natural setting.

Conference organizers Frank, Martin and Nagao, windblown on the Island Queen cruise boat.

Sunset behind the Stockey Centre Lilacs in bloom in Parry Sound Georgian Bay shore behind Stockey Centre

The science consisted of 90 talks (3 parallel sessions over 3 days), which ranged from the physical techniques, synthesis and properties, to medical applications. Ed Solomon‘s plenary lecture on copper–dioxygen reactivity closed the conference, while over 30 posters completed the program.

My favourite talks were those given by Wojciech Bal (U Warsaw) on nickel toxicity, Kyung-Bin Cho (Ewha Womans U) on rebound reactions in non-heme systems, Andrew Cammidge (U East Anglia) on Pcs-Por hybrids, Peter Caravan (Harvard Medical School) on MRI probes, Tim Storr (Simon Fraser U) on treating Alzheimer’s disease, Danny Leznoff (also at SFU) on metallo-Pcs, Jennifer Wytko (U Strasbourg) on porphyrin wires and Ian Butler (McGill U) on analysing artists’ pigments.
The fun included a boat cruise on the bay (a welcome and relaxing break), two music recitals in the evening, and an after-conference all-day outing to Killbear Provincial Park for hiking, kayaking and a BBQ. (More on the outing in an upcoming post, with photos.)

Island Queen cruise ship in Parry Sound Hole in the Wall passage in Georgian Bay Lighthouse on Georgian Bay

The cruise on the Island Queen was a welcome and relaxing break—staying warm inside the boat with occasional forays outside for photo ops.

The CanBIC conferences also feature music, provided by Katie Stillman on violin and Miaomiao Yu on piano. These two young talented musicians have played together for many years, which was evident from their perfect harmony in pieces ranging from Mozart to 20th century composers.

After this informal and small conference out in the woods, next week will be a complete change of scenery as I’m off to the 96th Canadian Society of Chemistry conference in Quebec City. Check back for my comments on this event.

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Where to meet the NJC team in 2013

Will you be attending one of the following conferences at which one of the NJC Editors will also be present? 

 Symposium on Foldamers — 10–12 April, Paris (France) — meet Laurent
Journées Scientifiques SCF: Section PACA — 11 April, Nice (France) — meet Ling
4th Georgian Bay International Conference on Bioinorganic Chemistry —21–25 May, Parry Sound (Canada) — meet Denise
96th Canadian Chemistry Conference — 26–30 May, Quebec City (Canada) — meet Denise
GECOM-Concoord — 26–31 May, Cap d’Agde (France) — meet Yannick
5th European Conference Chemistry for Life Sciences (5ECCLS) — 10–12 June, Barcelona (Spain) — meet Eva
The 8th International Dendrimer Symposium (IDS-8) — 23–27 June, Madrid (Spain) — meet Ling
20th EuCheMS Conference on Organometallic Chemistry (EuCOMC) — 30 June–4 July, St Andrews (UK) — meet Denise
18th European Symposium on Organic Chemistry (ESOC) — 7–12 July, Marseille (France) — meet Ling
International Conference on Advanced Complex Inorganic Nanomaterials — 15–19 July, Namur (Belgium) — meet Denise
XIV European Symposium on Organic Reactivity (ESOR) — 1–6 September, Prague (Czech Republic) — meet Eva
Organometallic & Coordination Chemistry: Fundamental and Applied Aspects — 1–7 September, cruise on Volga & Sheksna Rivers from Nizhny Novgorod (Russia) — meet Yannick
International Conference on Nanoscience & Technology (ChinaNANO) — 5–7 September, Beijing (China) — meet Ling
5th BBBB Drug Delivery — 26–28 September, Athens (Greece) — meet Ling
ILMAT 2013 — 18–20 November, Montpellier (France) — meet Yannick 

More details on what we’ll be doing at these meetings will be posted on the blog in the coming months — keep an eye on this space to find out more.
 

Do drop us a line if you’ll be there too — we’d enjoy meeting you!

Denise Parent (Editor), Eva Balentova (Deputy Editor), Yannick Guari, Ling Peng and Laurent Vial (Assistant Editors)

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