The seasonal design of December’s outside cover from Dr Ryo Tsunashima (Yamaguchi University, Japan) illustrates a study in which the authors report the synthesis and acid-base properties of a proton-bridged biaryl compound based on pyridylazulene.
Dr Tsunashima and his colleagues show that the intramolecular proton bridge between bipyridyl groups behaves as a chelating ligand to accommodate protons in solution, followed by stabilization of a unique steric structure.
Synthesis and acid–base properties of a proton-bridged biaryl compound based on pyridylazulene
Kazuki Ninomiya, Yumi Harada, Tomoaki Kanetou, Yuma Suenaga, Toshihiro Murafuji and Ryo Tsunashima. New J. Chem., 2015, 39, 9079-9085. DOI: 10.1039/C5NJ01651G.
The inside cover of NJC is proposed by Dr Giuseppina De Luca (Università della Calabria, Italy). Dr De Luca and her co-authors focused their study on the behavior of naproxen and flurbiprofen—common anti-inflammatory drugs—in solution using NMR spectroscopy for understanding and rationalizing their biological role and possibly for designing improved analogues.
The strategy adopted in this work represents an effective way for probing the probability distributions of dissolved small to medium-size flexible molecules.
The conformational behaviour of naproxen and flurbiprofen in solution by NMR spectroscopy
Maria Enrica Di Pietro, Christie Aroulanda, Giorgio Celebre, Denis Merlet and Giuseppina De Luca. New J. Chem., 2015, 39, 9086-9097. DOI: 10.1039/C5NJ01753J.
See the full content of the December issue here
