In this NJC paper, Peng Zhang and co-workers (University of Cincinnati, US) have reported the development of a highly sensitive and selective colorimetric detection method for glutathione (GSH) over cysteine (Cys) or homocysteine (Hcy) using gold nanoparticles (AuNPs).
The detection scheme is based on the quasi-stable state of AuNPs in the presence of sodium nitrate and GSH. The significant differences in interparticle forces and the assembly process of AuNPs enable the discrimination of GSH over Cys and Hcy. The presence of GSH can be detected by the naked eye and its concentration determined by UV/Vis spectrometry.
Selective colorimetric detection of glutathione based on quasi-stable gold nanoparticles assembly by Bo Hu, Xian Cao and Peng Zhang New J. Chem., 2013, Advance Article DOI: 10.1039/C3NJ00978E
Interested in reading further? Why not download the full article now, FREE to access for a period of 4 weeks!
