New candidates for G-quadruplexes structures

In this NJC Hot Article, Lajos Kovács and colleagues consider the aggregation of 3-methylxanthine via experimental and theoretical approaches and show the formation of quartet sytems, revealing that 3-substituted xanthines could be a previously undescribed quadruplex-forming base.

3-Substituted xanthines as promising candidates for quadruplex formation: computational, synthetic and analytical studies, János Szolomájer, Gábor Paragi, Gyula Batta, Célia Fonseca Guerra, F. Matthias Bickelhaupt, Zoltán Kele, Petra Pádár, Zoltán Kupihár and Lajos Kovács, New J. Chem., 2011, Advance Article, DOI: 10.1039/C0NJ00612B, Paper

Curious? Why not read all about it here. This NJC paper has been rated as ‘hot’ and is FREE to access to all for a period of four weeks, after a simple registration process at: Let us know your thoughts and comments below!

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