RSC Medicinal Chemistry Blog

4th CPA-RSC Symposium on Medicinal Chemistry: Epigenetics as Targets for Drug Discovery

14 Oct 2013

The RSC is jointly hosting a Medicinal Chemistry symposia on epigenetics as targets for drug discovery, comprising of two events:

4th CPA-RSC Symposium on Medicinal Chemistry: Epigenetics as Targets for Drug Discovery
Shandong University, Jinan, 2-3 November 2013

RSC International symposium on Epigenetics
Shanghai Institute of Materia Medica, 5 November 2013

The symposia will focus on epigenetics as targets for drug discovery, including trends and frontiers in epigenetics and histone modulators. It will feature a mix of high-profile international speakers and Chinese speakers from both academia and industry.

4^th CPA-RSC Symposium on Medicinal Chemistry: Epigenetics as Targets for Drug Discovery:

The 2013 Chinese Medicinal Chemistry Symposium (CMCS) and the 4^th CPA-RSC Symposium on Medicinal Chemistry: Epigenetics as Targets for Drug Discovery will be held from November 2 to 3, 2013 in Jinan, China. It is co-sponsored by Medicinal Chemistry Professional Committee of Chinese Pharmaceutical Association and Royal Society of Chemistry, and organized by Shandong University.

The symposium aims to provide a platform for medicinal chemists to exchange research information, discuss challenges, promote collaboration, and facilitate the transfer of new technologies. This symposium will showcase cutting-edge and complementary medicinal chemistry approaches ranging from complex natural products to small molecule fragments

Speakers include:

Chun-Wa Chung, GlaxoSmithKline, Stevenage, UK
Paul Brennan, SGC Oxford, UK
Qi Jun, Harvard Medical School, USA
Paul Thompson, Scripps Research Institute, Florida, USA
Erik De Clerq, Katholieke Universiteit Leuven, Belgium
Luo Cheng, Shanghai Institute of Materia Medica, China
Lu Xianping, Chipscreen Biosciences Ltd, China
Y. George Zheng, University of Georgia, USA
Zhang Mingqiang, Regional Associate Editor MedChemComm and VP Amgen, Shanghai, China
Hao Fang, Shandong University, China
David James, Royal Society of Chemistry, UK

RSC International symposium on Epigenetics:

This event will be hosted by Professor Jingkang Shen. If you are interested in attending this event, please email Dr Qingqing Qi with your contact details and email address.

Speakers include:

Chun-Wa Chung, GlaxoSmithKline, Stevenage, UK
Paul Brennan, SGC Oxford, UK
Qi Jun, Harvard Medical School, USA

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RSC Organic Division Poster Symposium: Deadline for poster abstracts 02 October 2013

23 Sep 2013

By James Anson.

RSC Organic Division Poster Symposium: Deadline for poster abstracts 02 October 2013

The RSC Organic Division Poster Symposium is still accepting abstracts, but not for long. If you are a final year PhD student based in the UK/ROI and would like the opportunity to showcase your work to leading chemists in industry and academia, as well as your peers, make sure you submit your poster abstract by Wednesday 2^nd October.

The symposium will take place on Monday 2^nd December 2013, at The Chemistry Centre, Burlington House, London and there are several prizes available on the day. Alongside the £500 First Prize, there will also be a £500 “Selected by Industry” prize and two runners-up prizes of £250. And this year our headline sponsor, F. Hoffmann-La Roche are offering a further prize of a visit to their site in Basel, Switzerland, to the First and Industry prize winners.

Reasonable travel costs will be covered for the students who are selected to present at this meeting. If you would like to find out more about the symposium and submit an abstract, visit our symposium website

We would like to thank F. Hoffmann-La Roche, Ltd. for their generous support of this event.

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Christa E. Müller: MedChemComm’s new Associate Editor for Europe

16 Sep 2013

By James Anson.

MedChemComm is delighted to welcome Professor Christa E. Müller (University of Bonn, Germany) as our new Associate Editor for Europe.

Christa is now accepting submissions so you can submit your next top research article to her!

Biography

Christa Müller studied pharmacy at the University of Tübingen, Germany, and received her Ph.D. in Pharmaceutical/Medicinal Chemistry from the same university. After a postdoctoral stay with John W. Daly (1989-1990 and 1992) at the Laboratory of Bioorganic Chemistry, National Institutes of Health, in Bethesda, Maryland, USA, she completed her habilitation thesis at the University of Tübingen in 1994, and became Associate Professor of Pharmaceutical Chemistry at Würzburg University in the same year. Since 1998 she is full professor of Pharmaceutical Chemistry at Bonn University. She is a co-founder of the Pharma-Center Bonn (www.pharmazentrum.uni-bonn.de), and has >250 publications in the field of medicinal chemistry and pharmacology.

Her scientific interests are focused on the medicinal chemistry and molecular pharmacology of purine-binding membrane proteins (purine receptors, ectonucleotidases) and lipid-activated orphan G protein-coupled receptors. Disease indications include neurodegenerative and inflammatory diseases and cancer. Her activities are ranging from basic research to collaborative drug development projects with pharma industry partners.

“MedChemComm has what it takes to become a leading journal of Medicinal Chemistry. It fills a gap since it differs from other med chem journals due to its wide scope and its unique format. I’m looking forward to seeing everyone’s exciting contributions and support!“

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Christa E. Müller

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Chemical and Biological Therapeutic Approaches to Neurological Disorders II

16 Sep 2013

By James Anson.

There’s still time to register for the second one-day symposium on Chemical and Biological Therapeutic Approaches to Neurological Disorders, on Monday 23^rd September. The meeting will feature presentations and posters, from leading experts in academia and industry, about new developments in genetics, biochemistry, pathophysiology and medicinal chemistry relating to neurological disorders. A wide range of conditions will be discussed, including Alzheimer’s disease, epilepsy, schizophrenia, multiple sclerosis and Parkinson’s disease.

Neurological disorders are an increasingly important global public health problem, and the cause of much long-term suffering and disability. Currently available pharmaceuticals have been ineffective in curing many of these disorders and developing a deeper understanding of the nervous system is one of the major challenges facing scientists in the 21^st century. New research will hopefully contribute to the identification of better clinical biomarkers and medicines for diagnosis, monitoring and treatment of neurological disorders.

This one day symposium has been organised by the RSC’s Biotechnology Group with support from the Chemistry Biology Interface Division, and will be held at The Chemistry Centre, Burlington House, London. Speakers include:

Prof. Christopher Dobson, University of Cambridge
Prof. Ciaran Regan, University College Dublin
Prof. Lennart Bunch, University of Copenhagen
Prof. Peter Jenner, King’s College London
Prof. Stefan Przyborski, University of Durham
Dr. Jan Kehler, H. Lundbeck, A/S
Prof. Jonathan Corcoran, University College Dublin
Dr. Jan Passchier, Imanova Ltd.

If you would like to attend, please register here.

If you would like to find out more about this event, more information can be found on the RSC website.

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Tools and Strategies to Find Chemical Probes for Your Protein – The Role of Computer-Aided Drug Discovery

02 Sep 2013

By Alessia Millemaggi.

You are invited to attend a joint Biochemical Society/Royal Society of Chemistry Workshop entitled Tools and Strategies to Find Chemical Probes for Your Protein – The Role of Computer-Aided Drug Discovery.

15 November 2013
Charles Darwin House, London, WC1N 2JU, UK

Application and Abstract deadline: 16 September 2013

This workshop aims to bring together biological scientists and computational chemists to discuss research challenges and facilitate collaborations. The workshop will be of particular interest to biological scientists who require new chemical reagents to help them to better understand biological mechanisms and to computational chemists who wish to apply computational ligand discovery methods to a biological problem. Please feel free to pass this message onto colleagues at your institution who may have interest in attending the workshop. The programme will feature oral presentations, flash poster presentations and discussion sessions. There will also be plenty of networking opportunities dispersed throughout the day.

Speakers and Facilitators:

Pedro Ballister, European Bioinformatics Institute, Cambridge, UK
Chas Bountra, University of Oxford, UK
Ruth Brenk, Johannes Gutenberg University Mainz, Germany
David Brown, University of Kent, UK
Grant Churchill, University of Oxford, UK
John Irwin, University of California, USA
Paul Hawkins OpenEye Scientific Software, UK
Taufiq Rahman, University of Cambridge, UK
Dahlia Weiss, Heptares Therapeutics UK

Organising Committee

Grant Churchill, University of Oxford, UK
Taufiq Rahman, University of Cambridge, UK
John Irwin, University of California, USA
David Brown, University of Kent, UK

Attendance is by application only and will be FREE of charge for Biochemical Society and Royal Society of Chemistry members. Delegates are encouraged to submit poster abstracts for flash and poster presentation. This workshop is the fourth of a series entitled “Analytical Tools for the Life Sciences”, a collaborative project between the Biochemical Society and Royal Society of Chemistry.

For more information please visit the event webpage.

Don’t miss out! Application and Abstract deadline is the 16 September 2013.

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MedChemComm call for papers: Carbohydrate themed issue

28 Aug 2013

By Richard Kelly.

MedChemComm themed issue: Carbohydrates

Guest Editors: Sylvie Garneau-Tsodikova (University of Kentucky, USA) and Timor Baasov (Technion-Israel Institute of Technology, Israel)

Submission Deadline: 28^th February 2014

Submissions are now open for a high-profile themed issue on Carbohydrates, due for publication in MedChemComm in summer 2014. The scope of the issue covers all areas of carbohydrate chemistry and biology which are relevant to drug discovery.

New research in MedChemComm is published as Concise Articles: flexible articles that have no strict page limits or formatting requirements. Manuscripts can be submitted in any reasonable format using our submission system. Template is not required. Please indicate that it is for the Carbohydrates themed issue in the comments to the editor field. The level of quality of this issue will be high, and all manuscripts will undergo the journal’s normal peer review process.

The deadline for submissions to the themed issue is 28^th February 2014, although submissions before this date are of course welcomed.

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Q2 top 10 for MedChemComm

13 Aug 2013

By Aliya Anwar.

Please take a look at the top 10 most accessed MedChemComm articles for the second quarter of 2013:

Metabolism-guided drug design
Antonia F. Stepan, Vincent Mascitti, Kevin Beaumont and Amit S. Kalgutkar
Med. Chem. Commun., 2013, 4, 631-652
DOI: 10.1039/C2MD20317K

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines
Alexander Ciupa, Paul A. De Bank, Mary F. Mahon, Pauline J. Wood and Lorenzo Caggiano
Med. Chem. Commun., 2013, 4, 956-961
DOI: 10.1039/C3MD00077J

Minisci reactions: Versatile CH-functionalizations for medicinal chemists
Matthew A. J. Duncton
Med. Chem. Commun., 2011, 2, 1135-1161
DOI: 10.1039/C1MD00134E

A critical assessment of modeling safety-related drug attrition
Daniel Muthas, Scott Boyer and Catrin Hasselgren
Med. Chem. Commun., 2013, 4, 1058-1065
DOI: 10.1039/C3MD00072A

Increasing small molecule drug developability in sub-optimal chemical space
Timothy J. Ritchie, Simon J. F. Macdonald, Simon Peace, Stephen D. Pickett and Christopher N. Luscombe
Med. Chem. Commun., 2013, 4, 673-680
DOI: 10.1039/C3MD00003F

Recent applications of multicomponent reactions in medicinal chemistry
Paul Slobbe, Eelco Ruijter and Romano V. A. Orru
Med. Chem. Commun., 2012, 3, 1189-1218
DOI: 10.1039/C2MD20089A

On the origins of drug polypharmacology
Xavier Jalencas and Jordi Mestres
Med. Chem. Commun., 2013, 4, 80-87
DOI: 10.1039/C2MD20242E

Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications
Paul C. Trippier and Christopher McGuigan
Med. Chem. Commun., 2010, 1, 183-198
DOI: 10.1039/C0MD00119H

Silver nanoparticles—the real “silver bullet” in clinical medicine?
Kenneth K. Y. Wong and Xuelai Liu
Med. Chem. Commun., 2010, 1, 125-131
DOI: 10.1039/C0MD00069H

The use of phosphate bioisosteres in medicinal chemistry and chemical biology
Thomas S. Elliott, Aine Slowey, Yulin Ye and Stuart J. Conway
Med. Chem. Commun., 2012, 3, 735-751
DOI: 10.1039/C2MD20079A

We very much welcome your thoughts and comments below:

Interested in submitting your own work to MedChemComm? Submit online today, or email us with your suggestions!

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MedChemComm papers in 2013 Cancer Nanotechnology collection

30 Jul 2013

By Alessia Millemaggi.

We are pleased to present a web collection of articles from publications across the RSC journal portfolio demonstrating the use of (nano)technology in the diagnosis, imaging and treatment of cancer.

Here are some Med Chem Comm articles in this special cancer nanotechnology collection:

Towards biocompatible nanovalves based on mesoporous silica nanoparticles
Ying-Wei Yang
Med. Chem. Commun., 2011,2, 1033-1049
DOI: 10.1039/C1MD00158B

Silver nanoparticles—the real “silver bullet” in clinical medicine?
Kenneth K. Y. Wong and Xuelai Liu
Med. Chem. Commun., 2010,1, 125-131
DOI: 10.1039/C0MD00069H

Engineering of peglayted camptothecin into core–shell nanomicelles for improving solubility, stability and combination delivery
Haiqing Dong, Chunyan Dong, Yue Feng, Tianbin Ren, Zhonghai Zhang, Lan Li and Yongyong Li
Med. Chem. Commun., 2012,3, 1555-1561
DOI: 10.1039/C2MD20153D

Hard shell gas-filled contrast enhancement particles for colour Doppler ultrasound imaging of tumors
H. Paul Martinez, Yuko Kono, Sarah L. Blair, Sergio Sandoval, Jessica Wang-Rodriguez, Robert F. Mattrey, Andrew C. Kummel and William C. Trogler
Med. Chem. Commun., 2010,1, 266-270
DOI: 10.1039/C0MD00139B

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Poster Session at the 2013 Medicinal Chemistry Residential School

04 Jul 2013

By Alessia Millemaggi.

Sunday night saw the inaugural poster session at the 2013 RSC Medicinal Chemistry Summer School. In total 16 delegates presented their work on the evening. A broad spectrum of chemistry was discussed over a glass of wine and posters provided a great way to see the research interests of delegates. There were 2 poster prizes up for grabs – a 1 year subscription to MedChemComm and a book from the RSC Books Drug Discovery Series.
On Monday morning, Andy Davis announced the winners; there was a tie for the MedChemComm sponsored Prize which was shared between:

Louis Allot ( University of Hull) for his work on PET imaging of nuclear receptor expression.
Kate Nicholson (University of Hull) for her work on synthesis and evaluation of novel coordination complexes as CXCR4 antagonists.

Delegates also had an opportunity to vote for their favourite poster, the winner of the “participants prize” went to Madura Jayatunga (University of Oxford) for his work on non-covalent and covalent inhibitors of the HIF1a-p300 interaction. Madura received the RSC Book Prize – New Therapeutic Strategies for Type 2 Diabetes.

Thanks to our 2 judges Andy Davis and Roger Griffin; and of course everyone that took part!

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Chemistry skills for drug discovery

17 Jun 2013

By Alessia Millemaggi.

Read a Royal Society of Chemistry position paper.

Chemistry expertise is critical to technical success across the spectrum of innovative medicines R&D. This position paper describes the changes that have taken place in the drug discovery sector and the challenges this presents in terms of ensuring chemistry, as the key enabling science, continues to deliver the essential translation of biological opportunity into clinical application.

It includes:

Impact of recent developments on training capacity and mobility
Key skills and capabilities for drug discovery chemists

Read the full position paper by David Fox at RSC Science

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RSC Medicinal Chemistry Blog

4th CPA-RSC Symposium on Medicinal Chemistry: Epigenetics as Targets for Drug Discovery

RSC Organic Division Poster Symposium: Deadline for poster abstracts 02 October 2013

Christa E. Müller: MedChemComm’s new Associate Editor for Europe

Chemical and Biological Therapeutic Approaches to Neurological Disorders II

Tools and Strategies to Find Chemical Probes for Your Protein – The Role of Computer-Aided Drug Discovery

MedChemComm call for papers: Carbohydrate themed issue

Q2 top 10 for MedChemComm

MedChemComm papers in 2013 Cancer Nanotechnology collection

Poster Session at the 2013 Medicinal Chemistry Residential School

Chemistry skills for drug discovery

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