Hengmiao Cheng and colleagues have synthesised a compound through integration of structure based drug design (SBDD) and physical properties based optimization (PPBO) with in vivo and in vitro great efficacy.
Currently, this compound is being evaluated in human clinical trilas for the treatment of cancer.
Read more and comment on it here:
Hengmiao Cheng, Shubha Bagrodia, Simon Bailey, Martin Edwards, Jacqui Hoffman, Qiyue Hu, Robert Kania, Daniel R. Knighton, Matthew A. Marx, Sacha Ninkovic, Shaoxian Sun and Eric Zhang
Med. Chem. Commun., 2010, 1, 139-144
DOI: 10.1039/C0MD00072H
DOI: 10.1039/C0MD00072H
