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Discovery science meets technology – Emerging Investigators

17 Oct 2016

We are both proud and very pleased to introduce the 2016 edition of our Emerging Investigators issue, which celebrates the most promising and brightest amongst early career miniaturisation scientists around the world.

Guest editors Charles M. Schroeder, Sarah Köster and Yanyi Huang introduce the issue in their Editorial.

Emerging Investigators 2016: discovery science meets technology
DOI: 10.1039/C6LC90076C

Read the full collection online today: http://rsc.li/loc-emginv-16

Free* Access: AC electric field induced droplet deformation in a microfluidic T-junction
Communication
Heng-Dong Xi, Wei Guo, Michael Leniart, Zhuang Zhi Chong and Say Hwa Tan
Lab Chip, 2016,16, 2982-2986 DOI: 10.1039/C6LC00448B

Open Access: A rrayed water-in-oil droplet bilayers for membrance transport analysis
R. Watanabe, N. Soga, M. Hara and H. Noji
Lab Chip, 2016,16, 3043-3048
DOI: 10.1039/C6LC00155F

Free* Access: Cell-on-hydrogel platform made of agar and alginate for rapid, low-cost, multidimensional test of antimicrobial susceptibility
Han Sun, Zhengzhi Liu, Chong Hu and Kangning Ren
Lab Chip, 2016,16, 3130-3138
DOI: 10.1039/C6LC00417B

Free Access*: One-step immunoassay of C-reactive protein using droplet microfluidics
Matthew Y. H. Tang and Ho Cheung Shum
Lab Chip, 2016, Advance Article
DOI: 10.1039/C6LC01121G

*Access is free until 11 November 2016 via a registered RSC account.

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Recent Advances in 3D Printing

09 Sep 2016

Guest edited by Jennifer Lewis (Harvard University) and Howard Stone (Princeton University) this collection of papers showcases recent advances in the rapidly evolving field of 3D printing, with an emphasis on themes that impact lab-on-a-chip applications.

Free* Access: The upcoming 3D-printing revolution in microfluidics
Critical Review
Nirveek Bhattacharjee, Arturo Urrios, Shawn Kang and Albert Folch
Lab Chip, 2016,16, 1720-1742 DOI: 10.1039/C6LC00163G

Free* Access: High density 3D printed microfluidic valves, pumps and multiplexers
HOT Article
Hua Gong, Adam Trticle. Woolley and Gregory P. Nordin
Lab Chip, 2016,16, 2450-2458 DOI: 10.1039/C6LC00565A

Free* Access: Bioprinted Thrombosis-on-a-Chip
HOT Article
Rahmi Oklu et al.
Lab Chip, 2016, Accepted Manuscript, C6LC00380J

Open Access: 3D- printed microfluidic devices: enablers and barriers
Michael C. Breadmore., et al
Lab Chip, 2016,16, 1993-2013
DOI: 10.1039/C6LC00284F

This collection also features a video demonstration:

3D printing of liquid metals as fugitive inks for fabrication of 3D microfluidic channels
Dishit P. Parekh, Collin Ladd, Lazar Panich, Khalil Moussa and Michael D. Dickey
Lab Chip, 2016,16, 1812-1820 DOI: 10.1039/C6LC00198J

Browse our 3D Printing collection – we hope you enjoy the articles

*Access is free until 10th October via a registered RSC account.

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2014 Insights Issue

18 Aug 2014

Guest editor, George Whitesides, introduces this series of Insights in Lab on a Chip’s 200^th editorial.

Collectively, these Insights demonstrate how the emphasis in LOC science and technology is shifting from foundational areas, such as methods of micofabrication and the physics of microscale flows, to serious explorations of uses and to demonstrations of applications. It is this research that provides the incentive for further and more extensive industrial engineering development and ultimately the incorporation into products. We hope you enjoy reading the collection as much as we did.

Frontiers

Energy: the microfluidic frontier

David Sinton
Lab Chip, 2014, 14, 3127-3134
DOI: 10.1039/C4LC00267A

Physics and technological aspects of nanofluidics

Lyderic Bocquet and Patrick Tabeling
Lab Chip, 2014, 14, 3143-3158
DOI: 10.1039/C4LC00325J

Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics

David Erickson, Dakota O’Dell, Li Jiang, Vlad Oncescu, Abdurrahman Gumus, Seoho Lee, Matthew Mancuso and Saurabh Mehta
Lab Chip, 2014, 14, 3159-3164
DOI: 10.1039/C4LC00142G

Critical Review

Biomedical imaging and sensing using flatbed scanners

Zoltán Göröcs and Aydogan Ozcan
Lab Chip, 2014, 14, 3248-3257
DOI: 10.1039/C4LC00530A

Read the full themed collection online today!

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200th Issue of Lab on a Chip

28 Jul 2014

We are delighted to announce the publication of our 200th issue of Lab on a Chip– how we have grown!

Launched in 2001, publishing 2 issues with a total of 31 articles that year, LOC is now publishing 24 issues a year. Many of the young researchers that published in the first issue have now become Professors themselves, and many have gone on to become award winners. Read the full editorial by our Editor, Harp Minhas to find out more!

This picture shows how the image of LOC has developed from the original cover to the LOC we are familiar with today.

To celebrate this achievement, we have made all of the HOT articles in the 200th issue of LOC free* to access throughout August. Click on the links below to download.

A lab-in-a-briefcase for rapid prostate specific antigen (PSA) screening from whole blood

Ana I. Barbosa, Ana P. Castanheira, Alexander D. Edwards and Nuno M. Reis

Lab Chip, 2014, 14, 2918-2928
DOI: 10.1039/C4LC00464G

Delayed voltammetric with respect to amperometric electrochemical detection of concentration changes in microchannels

Raphaël Trouillon and Martin A. M. Gijs

Lab Chip, 2014, 14, 2929-2940
DOI: 10.1039/C4LC00493K

Paired single cell co-culture microenvironments isolate by two-phase flown with continuous nutrient renewal

Yu-Chih Chen, Yu-Heng Cheng, Hong Sun Kim, Patrick N. Ingram, Jacques E. Nor and Euisik Yoon

Lab Chip, 2014, 14, 2941-2947
DOI: 10.1039/C4LC00391H

“Lab on a Chip itself has had an enormous influence on the development of the field, by setting very high scientific standards, by providing a common forum and vocabulary, by highlighting significant results, and by attracting some of the best scientists. The journal, and Harp Minhas as the spirit of the journal, have provided a coherence to Lab-on-a-chip science and technology that have had enormous influence in channeling the direction of the field”

Professor George Whitesides, Chair of Editorial Board, Lab on a Chip

*Access is free through a registered RSC account until 31st August 2014 – click here to register

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New challenges spawn new innovations

24 Jul 2014

Guest edited by Dino di Carlo, Helene Andersson-Svah and Yanyi Huang, this issue celebrates the best and brightest amongst early career miniaturisation scientists around the world. Their editorial reflects on the past before introducing the upcoming challenges that new generations of investigators are facing. These challenges are demonstrated in the range of topics covered in this issue.

Read the full Emerging Investigator themed collection now – we hope you enjoy the articles

This issue features three HOT articles, which received particularly high scores at peer review. They are free* to access for a limited time only so click on the links below to download the full articles

Magnetically controllable SD microtissues based on magnetic microcryogels

Wei Liu, Yaqian Li, Siyu Feng, Jia Ning, Jingyu Wang, Maling Gou, Huijun Chen, Feng Xu and Yanan Du

Lab Chip, 2014, 14, 2614-2625
DOI: 10.1039/C4LC00081A

A simple strategy for in situ fabrication of a smart hydrogel microvalve within microchannels for thermostatic control

Shuo Lin, Wei Wang, Xiao-Jie Ju, Rui Xie and Liang-Yin Chu

Lab Chip, 2014, 14, 2626-2634
DOI: 10.1039/C4LC00039K

Make is spin: individual trapping of sperm for analysis and recovery using micro-contact printing

J.-P. Frimat, M. Bronkhorst, B. de Wagenaar, J. G. Bomer, F. van der Heijden, A. van den Berg and L. I. Segerink

Lab Chip, 2014, 14, 2635-2641
DOI: 10.1039/C4LC00050A

*Access is free through a registered RSC account untill 22nd September 2014 – click here to register

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Themed Issue dedicated to Kahp-Yang Suh

02 Jul 2014

An extraordinarily insightful and productive scientist in the field of nanotechnology, material science and bio-inspired systems, Kahp-Yang Suh has published over 200 articles over his short academic life.

Guest edited by Pilnam Kim, Noo Li Jeon and Ali Khademhosseini, this issue includes seven research papers concerning various areas of lab-on-a-chip, written by friends and colleagues of Khap-Yang and includes contributions on a range of topics related to Kahp-Yang’s work. These papers demonstrate the directions in which lab-on-a-chip and intelligent manufacturing of biomaterials could contribute to the development of the next generation of healthcare systems.

Click here to read the full collection, celebrating Kahp-Yang’s contribution to microfluidics research.

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LOC issue 4 – the Neuroengineering 2013 themed issue is online now!

24 Jan 2013

Lab on a Chip’s 2013 Neuroengineering themed issue is introduced by guest editors David T. Eddington and Justin Williams, who also contributed the outside front cover design. This is followed by profiles of all of the contributors to the Neuroengineering themed issue.

Neuroengineering
David T. Eddington and Justin Williams
DOI: 10.1039/C3LC90003G

As well as plenty of cutting-edge primary research into lab on a chip technology for neuroengineering, Issue 4 includes two Critical Reviews.

A critical review of the development of engineered cell culture substrates and techniques for investigating axon development guidance by Santiago Costantino et al. at University of Montreal and McGill University, Canada, is highlighted on the inside front cover. They look at the opportunities that are now opening up due to these new technological developments, the biological insights that can now be gained and the breakthroughs waiting to happen in the near future.

Engineered cell culture substrates for axon guidance studies: moving beyond proof of concept
Joannie Roy, Timothy E. Kennedy and Santiago Costantino
DOI: 10.1039/C2LC41002H

The second critical review from Noo Li Jeon et al. at Seoul National University, Korea, and The Salk Institute, USA, summarises the most recent technological developments of BioMEMs devices and their application to neuroscience research. They look at platforms for disease culture, modelling disease in vitro, neuron electrophysiology and stem cell biology.

Advances in microfluidics-based experimental methods for neuroscience research
Jae Woo Park, Hyung Joon Kim, Myeong Woo Kang and Noo Li Jeon
DOI: 10.1039/C2LC41081H

The HOT articles in this issue include:

Integration of pre-aligned liquid metal electrodes for neural stimulation within a user-friendly microfluidic platform
Nicholas Hallfors, Asif Khan, Michael D. Dickey and Anne Marion Taylor
DOI: 10.1039/C2LC40954B

Inherent amplitude demodulation of an AC-EWOD (electrowetting on dielectric) droplet
Myung Gon Yoon, Sang Hyun Byun and Sung Kwon Cho
DOI: 10.1039/C2LC41043E

One-step polymer surface modification for minimizing drug, protein, and DNA adsorption in microanalytical systems
Esben Kjær Unmack Larsen and Niels B. Larsen
DOI: 10.1039/C2LC40750G

To learn all about the exciting advances happening in applying microtechnology to neuroengineering, read the full issue here

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Issue 22 – Focus on Scandinavia

30 Oct 2012

Issue 22 of Lab on a Chip features work from Scandinavia – read the editorial from the Guest Editors Professors Thomas Laurell and Jörg Kutter here. The issue features 8 articles from Scandinavian authors, and profiles of the athours included can be found here.

The front cover features work from Jörg Kutter and co-workers at the Technical University of Denmark, reporting on the optical properties of gold nanoparticle probes, used as sensors for environmental contaminants.

Gold nanoparticle-based optical microfluidic sensors for analysis of environmental pollutants
Josiane P. Lafleur, Silja Senkbeil, Thomas G. Jensen and Jörg P. Kutter
DOI: 10.1039/C2LC40543A

Artwork linked to research from Vincent Aimez and colleagues from the Université de Sherbrooke can be seen on the inside front cover of the issue – they have developed a microfluidic device to monitor the radioactivity concentration in the blood of rats and mice in real time.

Blood compatible microfluidic system for pharmacokinetic studies in small animals
Laurence Convert, Frédérique Girard Baril, Vincent Boisselle, Jean-François Pratte, Réjean Fontaine, Roger Lecomte, Paul G. Charette and Vincent Aimez
DOI: 10.1039/C2LC40550D

The back cover of the issue features work from Samir Iqbal and co-workers at the University of Texas and Lehigh University. The team designed a Hele-Shaw device with aptamer functionalized glass beads to isolate cancer cells from a cellular mixture.

Capture, isolation and release of cancer cells with aptamer-functionalized glass bead array
Yuan Wan, Yaling Liu, Peter B. Allen, Waseem Asghar, M. Arif Iftakher Mahmood, Jifu Tan, Holli Duhon, Young-tae Kim, Andrew D. Ellington and Samir M. Iqbal
DOI: 10.1039/C2LC21251J

Other HOT papers in the issue include:

Two-hundredfold volume concentration of dilute cell and particle suspensions using chip integrated multistage acoustophoresis
Maria Nordin and Thomas Laurell
DOI: 10.1039/C2LC40629B

Inertial microfluidics in parallel channels for high-throughput applications
Jonas Hansson, J. Mikael Karlsson, Tommy Haraldsson, Hjalmar Brismar, W. van der Wijngaart and Aman Russom
DOI: 10.1039/C2LC40241F

Low cost integration of 3D-electrode structures into microfluidic devices by replica molding
Benjamin Mustin and Boris Stoeber
DOI: 10.1039/C2LC40728K

A microfluidic device with removable packaging for the real time visualisation of intracellular effects of nanosecond electrical pulses on adherent cells
C. Dalmay, M. A. De Menorval, O. Français, L. M. Mir and B. Le Pioufle
DOI: 10.1039/C2LC40857K

Programmable microfluidic synthesis of spectrally encoded microspheres
R. E. Gerver, R. Gómez-Sjöberg, B. C. Baxter, K. S. Thorn, P. M. Fordyce, C. A. Diaz-Botia, B. A. Helms and J. L. DeRisi
DOI: 10.1039/C2LC40699C

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Hot articles from our Emerging Investigators

20 Sep 2012

We’re delighted to announce the publication of our 2012 Emerging Investigators issue, which contains a massive 6 HOT articles! Read the editorial from Amy Herr and Aaron Wheeler to find out why this group of researchers is affectionately known as control freaks..

Controllable microfluidic production of gas-in-oil-in-water emulsions for hollow microspheres with thin polymer shells
Ran Chen, Peng-Fei Dong, Jian-Hong Xu, Yun-Dong Wang and Guang-Sheng Luo
DOI: 10.1039/C2LC40387K

A rotary microsystem for simple, rapid and automatic RNA purification
Byung Hyun Park, Jae Hwan Jung, Hainan Zhang, Nae Yoon Lee and Tae Seok Seo
DOI: 10.1039/C2LC40487G

Cytotoxicity analysis of water disinfection byproducts with a micro-pillar microfluidic device
Austin Hsiao, Yukako Komaki, Syed M. Imaad, Benito J. Mariñas, Michael J. Plewa and G. Logan Liu
DOI: 10.1039/C2LC40374A

Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic emulsion PCR at the single-cell level
Zhi Zhu, Wenhua Zhang, Xuefei Leng, Mingxia Zhang, Zhichao Guan, Jiangquan Lu and Chaoyong James Yang
DOI: 10.1039/C2LC40461C

Enantioselective analysis of melagatran via an LSPR biosensor integrated with a microfluidic chip
Longhua Guo, Yuechun Yin, Rong Huang, Bin Qiu, Zhenyu Lin, Huang-Hao Yang, Jianrong Li and Guonan Chen
DOI: 10.1039/C2LC40388A

Real-time full-spectral imaging and affinity measurements from 50 microfluidic channels using nanohole surface plasmon resonance
Si Hoon Lee, Nathan C. Lindquist, Nathan J. Wittenberg, Luke R. Jordan and Sang-Hyun Oh
DOI: 10.1039/C2LC40455A

These articles will be free to access for the next 4 weeks. (Free access to individuals is provided through an RSC Publishing personal account. Registration is quick, free and simple.)

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Hot articles in optofluidics

29 Aug 2012

You might have already seen our themed issue on optofluidics but in case you haven’t, here are the HOT articles from this issue:

Yi-Chung Tung et al. review the recent advances in optofluidic technologies that will open up new possibilities for on-chip phenotyping

Optofluidic detection for cellular phenotyping
Yi-Chung Tung, Nien-Tsu Huang, Bo-Ram Oh, Bishnubrata Patra, Chi-Chun Pan, Teng Qiu, Paul K. Chu, Wenjun Zhang and Katsuo Kurabayashi
DOI: 10.1039/C2LC40509A

Kevin Raymond et al. have developed an ‘optofluidic nose’ for sensing organic liquids based on wetting in photonic-crystal arrays.

Combinatorial wetting in colour: an optofluidic nose
Kevin P. Raymond, Ian B. Burgess, Mackenzie H. Kinney, Marko Lončar and Joanna Aizenberg
DOI: 10.1039/C2LC40489C

Haiwang Li and colleagues demonstrate the design of a bi-concave lens to perform both light focusing and diverging in-plane.

An electrokinetically tunable optofluidic bi-concave lens
Haiwang Li, Chaolong Song, Trung Dung Luong, Nam-Trung Nguyen and Teck Neng Wong
DOI: 10.1039/C2LC40406K

Yasutaka Hanada and coworkers show how to create a highly sensitive optofluidic chip for biochemical liquid assays by coating microfluidic channels with a low refractive index polymer and use of an optical waveguide.

Highly sensitive optofluidic chips for biochemical liquid assay fabricated by 3D femtosecond laser micromachining followed by polymer coating
Yasutaka Hanada, Koji Sugioka and Katsumi Midorikawa
DOI: 10.1039/C2LC40377C

Jigang Wu, Guoan Zheng and Lap Man Lee focus on compact systems in their review of optical imaging techniques that can be integrated with microfluidics.

Optical imaging techniques in microfluidics and their applications
DOI: 10.1039/C2LC40517B

Chao-Min Cheng and colleagues provide thoughtful insight into the application of optofluidics to synthetic biology in this forward-looking Frontier article.

Frontiers of optofluidics in synthetic biology
Cheemeng Tan, Shih-Jie Lo, Philip R. LeDuc and Chao-Min Cheng
DOI: 10.1039/C2LC40828G

Shih-Kang Fan’s team manipulate 200 nL bubbles with DEP and ignite microplasma within them, with potential for future applications in the biomedical field.

Atmospheric-pressure microplasma in dielectrophoresis-driven bubbles for optical emission spectroscopy
Shih-Kang Fan, Yan-Ting Shen, Ling-Pin Tsai, Cheng-Che Hsu, Fu-Hsiang Ko and Yu-Ting Cheng
DOI: 10.1039/C2LC40499K

Wenqi Hu, Kelly S. Ishii, Qihui Fan and Aaron T. Ohta report a hydrogel microrobot which can be manipulated by laser-induced bubbles. Single or pairs of robots are able to assemble polystyrene beads and yeast cells into patterns.

Hydrogel microrobots actuated by optically generated vapour bubbles
Wenqi Hu, Kelly S. Ishii, Qihui Fan and Aaron T. Ohta
DOI: 10.1039/C2LC40483D

Remember, all our cover articles are free to access for 6 weeks, and our HOT articles for 4 weeks. All you need to access them is an RSC Publishing Personal Account – signing up is quick and easy.

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