Hot Articles – Page 17 – Lab on a Chip Blog

Archive for the ‘Hot Articles’ Category

LOC Issue 6 just published

24 Feb 2012

Issue 6 is now available online, and the outside front cover features a HOT article by Govind Kaigala and colleagues at IBM Research in Zürich on micro-immunohistochemistry (μIHC) using a microfluidic probe to extract more high-quality information from tissue sections for use in drug discovery and clinical pathology.

Micro-immunohistochemistry using a microfluidic probe
Robert D. Lovchik, Govind V. Kaigala, Marios Georgiadis and Emmanuel Delamarche
DOI: 10.1039/C2LC21016A

Issue 6 inside front cover The inside front cover features another HOT article, from Douglas Weibel and colleagues at the University of Wisconsin-Madison and the University of California, San Diego, describing very simple, portable microfluidic technology for determining the minimum inhibitory concentration of antibiotics.

A self-loading microfluidic device for determining the minimum inhibitory concentration of antibiotics
Nate J. Cira, Jack Y. Ho, Megan E. Dueck and Douglas B. Weibel
DOI: 10.1039/C2LC20887C

The issue also includes the Focus article ‘Standards for collecting microfluidic devices?‘ by Henne van Heeren at enablingMNT, discussing the need for standards for microfluidic interconnections, chip dimensions and a vocabulary, the latest article in our Acoustofluidics series on the acoustic radiation force on small particles by Henrik Bruus at the Technical University of Denmark, and the following HOT articles:

Sorting cells by size, shape and deformability
Jason P. Beech, Stefan H. Holm, Karl Adolfsson and Jonas O. Tegenfeldt
DOI: 10.1039/C2LC21083E

A microfluidic method to study demulsification kinetics
Thomas Krebs, Karin Schroen and Remko Boom
DOI: 10.1039/C2LC20930F

Design considerations for electrostatic microvalves with applications in poly(dimethylsiloxane)-based microfluidics
Amit V. Desai, Joshua D. Tice, Christopher A. Apblett and Paul J. A. Kenis
DOI: 10.1039/C2LC21133E

All our HOT articles are free to access for four weeks (following a simple registration for individual users).

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Our current HOT articles on cell sorting, demulsification kinetics, modelling microvalves and materials for chips

20 Feb 2012

Jason P. Beech and colleagues at Lund University use shape and deformability to sort cells, as well as the more usual parameter of size in this microfluidic device:

Sorting cells by size, shape and deformability
Jason P. Beech, Stefan H. Holm, Karl Adolfsson and Jonas O. Tegenfeldt
DOI: 10.1039/C2LC21083E

Thomas Krebs and colleagues at Wageningen University present the results of experiments studying droplet coalescence in a dense layer of emulsion droplets using microfluidic circuits:

A microfluidic method to study demulsification kinetics
Thomas Krebs, Karin Schroen and Remko Boom
DOI: 10.1039/C2LC20930F

Paul Kenis et al. present an analytical model to guide the design of electrostatic microvalves that can be integrated into microfluidic chips:

Design considerations for electrostatic microvalves with applications in poly(dimethylsiloxane)-based microfluidics
Amit V. Desai, Joshua D. Tice, Christopher A. Apblett and Paul J. A. Kenis
DOI: 10.1039/C2LC21133E

David Beebe et al. discuss the use of PDMS and polystyrene by researchers working at the interface of microfluidics and cell biology research:

Engineers are from PDMS-land, Biologists are from Polystyrenia
Erwin Berthier, Edmond W. K. Young and David Beebe
DOI: 10.1039/C2LC20982A

These HOT articles are free to access for the next four weeks (following a simple registration for individual users), so why not take a look?

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Issue 5 just published including hot articles on sensors for microgas chromatography

09 Feb 2012

Issue 5 front cover Issue 5 is now available online and on the outside front cover we have a hot article on the batch fabrication of disposable SERS arrays using screen printing with silver nanoparticle-containing ink from Lu-Lu Qu et al.

Batch fabrication of disposable screen printed SERS arrays
Lu-Lu Qu, Da-Wei Li, Jin-Qun Xue, Wen-Lei Zhai, John S. Fossey and Yi-Tao Long
DOI: 10.1039/C2LC20926H

On the inside front cover is another hot article, this time from Andrew Griffiths et al. who have developed an ultrahigh-throughput system which combines droplet PCR and IVTT to provide a completely in vitro screen.

Issue 5 inside front cover

A completely in vitro ultrahigh-throughput droplet-based microfluidic screening system for protein engineering and directed evolution
Ali Fallah-Araghi, Jean-Christophe Baret, Michael Ryckelynck and Andrew D. Griffiths
DOI: 10.1039/C2LC21035E

Plus you can read the latest Research Highlights from Ali Khademhosseini – shrink-film for cell culture, optically adjustable microfluidic chips and protein profiling with microgels – or the latest in our Acoustofluidics series on measurement techniques for the characterization of ultrasonic particle manipulation devices.

The issue also features several hot articles which will be free to access* for 4 weeks:

Rapid, sensitive, and multiplexed on-chip optical sensors for micro-gas chromatography
Karthik Reddy, Yunbo Guo, Jing Liu, Wonsuk Lee, Maung Kyaw Khaing Oo and Xudong Fan
DOI: 10.1039/C2LC20922E

Microfluidic single-cell cultivation chip with controllable immobilization and selective release of yeast cells
Zhen Zhu, Olivier Frey, Diana Silvia Ottoz, Fabian Rudolf and Andreas Hierlemann
DOI: 10.1039/C2LC20911J

Dual-electrode microfluidic cell for characterizing electrocatalysts
Ioana Dumitrescu, David F. Yancey and Richard M. Crooks
DOI: 10.1039/C2LC21181E

* Following a simple registration for individual users

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Have you seen our collection of review articles? Reviews on holographic optical tweezers to microfluidics for the food industry and optoelectrofluidics

01 Feb 2012

During 2011 we published a number of topical reviews on a wide range of topics by expert researchers in their fields. We’ve collected some of them below but take a look here for the whole list, we hope you’ll find something interesting in your area.

Holographic optical tweezers and their relevance to lab on chip devices
Miles Padgett and Roberto Di Leonardo

Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review
Mazher-Iqbal Mohammed and Marc P. Y. Desmulliez

Nanomanipulation using near field photonics
David Erickson, Xavier Serey, Yih-Fan Chen and Sudeep Mandal

Microfluidics for food, agriculture and biosystems industries
Suresh Neethirajan, Isao Kobayashi, Mitsutoshi Nakajima, Dan Wu, Saravanan Nandagopal and Francis Lin

Optoelectrofluidic platforms for chemistry and biology
Hyundoo Hwang and Je-Kyun Park

Disposable microfluidic substrates: Transitioning from the research laboratory into the clinic
Jason S. Kuo and Daniel T. Chiu

Miniaturized isothermal nucleic acid amplification, a review
Peter J. Asiello and Antje J. Baeumner

If you have an idea for a review article that hasn’t been covered and you would like to see included, contact the Editorial Office – we’d love to hear from you.

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Issue 4 just published including hot articles on self-propelling droplets, cell-resolution vertebrate screening & quick genotyping

26 Jan 2012

Issue 4 is now available online and on the outside front cover we have a hot article from on an automated cellular-resolution vertebrate screening platform from Mehmet Fatih Yanik and an equally exciting image to accompany it!

Fully automated cellular-resolution vertebrate screening platform with parallel animal processing
Tsung-Yao Chang, Carlos Pardo-Martin, Amin Allalou, Carolina Wählby and Mehmet Fatih Yanik
DOI: 10.1039/C1LC20849G

On the inside front cover is another hot article, this time from Katsuo Kurabayashi who has developed a vapor preconcentrator/injector for microscale GC.

Microfabricated passive vapor preconcentrator/injector designed for microscale gas chromatography
Jung Hwan Seo, Sun Kyu Kim, Edward T. Zellers and Katsuo Kurabayashi
DOI: 10.1039/C2LC20932B

The issue also features a whole host of hot articles on topics from education to droplets, which will be free to access for 4 weeks:

Education: a microfluidic platform for university-level analytical chemistry laboratories
Jesse Greener, Ethan Tumarkin, Michael Debono, Andrew P. Dicks and Eugenia Kumacheva
DOI: 10.1039/C2LC20951A

Self-propelling surfactant droplets in chemically-confined microfluidics – cargo transport, drop-splitting and trajectory control
David K. N. Sinz and Anton A. Darhuber
DOI: 10.1039/C2LC21082G

Droplet-based microfluidic device for multiple-droplet clustering
Jing Xu, Byungwook Ahn, Hun Lee, Linfeng Xu, Kangsun Lee, Rajagopal Panchapakesan and Kwang W. Oh
DOI: 10.1039/C2LC20883K

Quick genotyping detection of HBV by giant magnetoresistive biochip combined with PCR and line probe assay
Xiao Zhi, Qingsheng Liu, Xin Zhang, Yixia Zhang, Jie Feng and Daxiang Cui
DOI: 10.1039/C2LC20949G

Rapid prototyping of three-dimensional microfluidic mixers in glass by femtosecond laser direct writing
Yang Liao, Jiangxin Song, En Li, Yong Luo, Yinglong Shen, Danping Chen, Ya Cheng, Zhizhan Xu, Koji Sugioka and Katsumi Midorikawa
DOI: 10.1039/C2LC21015K

Ultrahigh sensitivity assays for human cardiac troponin I using TiO2 nanotube arrays
Piyush Kar, Archana Pandey, John J. Greer and Karthik Shankar
DOI: 10.1039/C2LC20892J

Also, take a look at the latest article in our acoustofluidics series – Building microfluidic acoustic resonators.

Building microfluidic acoustic resonators

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Focus on German research just published

11 Jan 2012

We are delighted to publish another in our series of 10th Anniversary issues, this time focussed on lab on a chip and miniaturisation technologies from research groups in Germany, guest edited by Holger Becker and Andreas Manz.

Read their editorial to learn more on the developments and collaborations within the microfluidics field in Germany, and take a look at the author profiles of the contributors to the issue.

Despite the fact that Germany is not necessarily well known for its entrepreneurial culture and abundance of venture capital investments, that we find many microfluidics service providers in Germany which manufacture devices in materials such as polymers (e.g., microfluidic ChipShop, ThinXXS, Boehringer Ingelheim microparts, Bartels Mikrotechnik) or glass (e.g., Little Things Factory, iX factory) which have been active in this field for many years.
– Holger Becker and Andreas Manz

View the issue

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Have you seen our new acoustofluidics tutorial series?

05 Jan 2012

A little while ago Henrik Bruus, Jurg Dual, Jeremy Hawkes, Martyn Hill, Thomas Laurell, Johan Nilsson, Stefan Radel, Satwindar Sadhal and Martin Wiklund met at the International Centre for Mechanical Sciences in northern Italy to give a lecture series on the theory and applications of ultrasonic standing wave technology and microfluidics. Out of this the idea for a series of tutorial papers was born, and Lab on a Chip is delighted to bring you the first few in the series:

Acoustofluidics 1: Governing equations in microfluidics
Henrik Bruus
DOI: 10.1039/C1LC20658C

Acoustofluidics 2: Perturbation theory and ultrasound resonance modes
Henrik Bruus
DOI: 10.1039/C1LC20770A

Acoustofluidics 3: Continuum mechanics for ultrasonic particle manipulation
Jurg Dual and Thomas Schwarz
DOI: 10.1039/C1LC20837C

Acoustofluidics 4: Piezoelectricity and application in the excitation of acoustic fields for ultrasonic particle manipulation
Jurg Dual and Dirk Möller
DOI: 10.1039/C1LC20913B

Don’t forget to check back soon for more articles in this exciting new area and if you have any comments on the series so far we’d love to hear them!

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Hot articles on bubble removal, microfluidic wound-healing assays, multiplexed screening and more

23 Dec 2011

We’re just about to wrap up here for Christmas, but before we go we thought we’d give you some hot articles to keep you warm until the new year…

Bubbles no more: in-plane trapping and removal of bubbles in microfluidic devices
Conrad Lochovsky, Sanjesh Yasotharan and Axel Günther
DOI: 10.1039/C1LC20817A

Microfluidic approach for highly efficient synthesis of heparin-based bioconjugates for drug delivery
Thanh Huyen Tran, Chi Thanh Nguyen, Dong-Pyo Kim, Yong-kyu Lee and Kang Moo Huh
DOI: 10.1039/C1LC20769E

Microfluidic wound-healing assay to assess the regenerative effect of HGF on wounded alveolar epithelium
Marcel Felder, Pauline Sallin, Laurent Barbe, Beat Haenni, Amiq Gazdhar, Thomas Geiser and Olivier Guenat
DOI: 10.1039/C1LC20879A

Droplet-based microfluidic device for multiple-droplet clustering
Jing Xu, Byungwook Ahn, Hun Lee, Linfeng Xu, Kangsun Lee, Rajagopal Panchapakesan and Kwang W. Oh
DOI: 10.1039/C2LC20883K

A digital microfluidic method for multiplexed cell-based apoptosis assays
Dario Bogojevic, M. Dean Chamberlain, Irena Barbulovic-Nad and Aaron R. Wheeler
DOI: 10.1039/C2LC20893H

A silicone-based stretchable micropost array membrane for monitoring live-cell subcellular cytoskeletal response
Jennifer M. Mann, Raymond H. W. Lam, Shinuo Weng, Yubing Sun and Jianping Fu
DOI: 10.1039/C2LC20896B

Remember these are free to access for four weeks if you are registered with us.

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HOT: Novel microsensor for heat transfer measurements in microchannels

21 Dec 2011

As more and more kinds of microfluidic devices are developed there is a growing need for sensors which can non-intrusively measure the heat and temperature effects taking place within them. To address this Hassan Peerhossaini and colleagues at the University of Nantes in France have developed a new kind of heat-flux temperature sensor based on thin-film thermoresistance technology.

The sensor consists of 40 gold thin-film thermoresistances (85 nm thick) on a borosilicate substrate (20 per side) which provide the temperature sensing points.

This paper reports the fabrication and characteristics of the sensor and describes its use to measure the heat transfer properties of straight microchannels 12.5 to 52.2 um high and 4 mm wide.

Want to find out more? Read the paper here.

A novel thin-film temperature and heat-flux microsensor for heat transfer measurements in microchannels
David Hamadi, Bertrand Garnier, Herve Willaime, Fabrice Monti and Hassan Peerhossaini
Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC20919E, Paper

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Lab on a Chip Issue 1 just published!

05 Dec 2011

Welcome to the first 2012 issue of Lab on a Chip

On the front cover of our first issue of Volume 12 an the article from Neus Sabaté et al. on their fuel cell-powered microfluidic platform for lab-on-a-chip applications. This hot article was recently highlighted in Chemistry World.

Fuel cell-powered microfluidic platform for lab-on-a-chip applications
Juan Pablo Esquivel, Marc Castellarnau, Tobias Senn, Bernd Löchel, Josep Samitier and Neus Sabaté
DOI: 10.1039/C1LC20426B

On the inside front cover we have an image from Eric Stava et al. showing their work on the mechanical actuation of ion channels using a piezoelectric planar patch clamp system.

Mechanical actuation of ion channels using a piezoelectric planar patch clamp system
Eric Stava, Minrui Yu, Hyun Cheol Shin, Hyuncheol Shin, Jonathan Rodriguez and Robert H. Blick
DOI: 10.1039/C1LC20636B

In this issue we also have the editorial introduction from Editor Harp Minhas – Meeting the challenge – discussing our new developments and plans for the coming year, we think it’s going to be an exciting one!

Take a look at the issue

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