Scientists in Spain have flipped the cell-on-a-chip concept to bring us a chip-on-a-cell
Jose Antonio Plaza of the Institute of Microelectronics Barcelona and colleagues affixed polysilicon chips, which act as barcodes, onto the outer surface of the zona pellucida, a membrane that surrounds immature egg cells and embryos. Although silicon nanowires penetrated the membrane to attach the chip, they did not interfere with embryo development in tests on mouse embryos.
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Silicon-nanowire based attachment of silicon chips for mouse embryo labelling
S. Durán, S. Novo, M. Duch, R. Gómez-Martínez, M. Fernández-Regúlez, A. San Paulo, C. Nogués, J. Esteve, E. Ibañez and J. A. Plaza
Lab Chip, 2015, Advance Article
DOI: 10.1039/C4LC01299B, Paper