A microfluidic device that recreates interactions between the gastrointestinal (GI) tract and the liver to give a more realistic assessment of nanoparticle toxicity has detected liver tissue injury at lower nanoparticle concentrations than expected following experiments with liver tissue only.
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Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
Mandy B. Esch, Gretchen J. Mahler, Tracy Stokol and Michael L. Shuler
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00371C, Paper