Organ–organ interactions could compound nanoparticle damage

Full Chemistry World article by Mary MacLeod, Publishing Editor at the Royal Society of Chemistry

A microfluidic device that recreates interactions between the gastrointestinal (GI) tract and the liver to give a more realistic assessment of nanoparticle toxicity has detected liver tissue injury at lower nanoparticle concentrations than expected following experiments with liver tissue only.

Many studies look at the beneficial medical effects of nanoparticles, however, Mandy Esch explains that her work in Michael Shuler’s lab at Cornell University is checking for adverse effects.

To read the full article, please visit Chemistry World.

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
Mandy B. Esch, Gretchen J. Mahler, Tracy Stokol and Michael L. Shuler
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00371C, Paper

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