Archive for July, 2012

Top ten most accessed articles in June

This month sees the following articles in Lab on a Chip that are in the top ten most accessed:

A paper and plastic device for performing recombinase polymerase amplification of HIV DNA
Brittany A. Rohrman and Rebecca R. Richards-Kortum
Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40423K

Commercialization of microfluidic point-of-care diagnostic devices
Curtis D. Chin, Vincent Linder and Samuel K. Sia
Lab Chip
, 2012,12, 2118-2134
DOI: 10.1039/C2LC21204H

Digital microfluidics: a versatile tool for applications in chemistry, biology and medicine
Mais J. Jebrail, Michael S. Bartsch and Kamlesh D. Patel
Lab Chip, 2012, 12, 2452-2463
DOI: 10.1039/C2LC40318H

Microfluidic electronics
Shi Cheng and Zhigang Wu
Lab Chip, 2012, 12, 2782-2791
DOI: 10.1039/C2LC21176A

Automated analysis of single stem cells in microfluidic traps
Stefan A. Kobel, Olivier Burri, Alexandra Griffa, Mukul Girotra, Arne Seitz and Matthias P. Lutolf
Lab Chip, 2012, 12, 2843-2849
DOI: 10.1039/C2LC40317J

Microengineered physiological biomimicry: Organs-on-Chips
Dongeun Huh, Yu-suke Torisawa, Geraldine A. Hamilton, Hyun Jung Kim and Donald E. Ingber
Lab Chip, 2012, 12, 2156-2164
DOI: 10.1039/C2LC40089H

High-yield cell ordering and deterministic cell-in-droplet encapsulation using Dean flow in a curved microchannel
Evelien W. M. Kemna, Rogier M. Schoeman, Floor Wolbers, Istvan Vermes, David A. Weitz and Albert van den Berg
Lab Chip, 2012, 12, 2881-2887
DOI: 10.1039/C2LC00013J

A fluidic diode, valves, and a sequential-loading circuit fabricated on layered paper
Hong Chen, Jeremy Cogswell, Constantine Anagnostopoulos and Mohammad Faghri
Lab Chip, 2012, 12, 2909-2913
DOI: 10.1039/C2LC20970E

High throughput method for prototyping three-dimensional, paper-based microfluidic devices
Gregory G. Lewis, Matthew J. DiTucci, Matthew S. Baker and Scott T. Phillips
Lab Chip, 2012, 12, 2630-2633
DOI: 10.1039/C2LC40331E

SSA-MOA: a novel CTC isolation platform using selective size amplification (SSA) and a multi-obstacle architecture (MOA) filter
Minseok S. Kim, Tae Seok Sim, Yeon Jeong Kim, Sun Soo Kim, Hyoyoung Jeong, Jong-Myeon Park, Hui-Sung Moon, Seung Il Kim, Ogan Gurel, Soo Suk Lee, Jeong-Gun Lee and Jae Chan Park
Lab Chip, 2012, 12, 2874-2880
DOI: 10.1039/C2LC40065K

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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New YouTube videos

View the new videos on the Lab on a Chip YouTube site using the links below:

Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells

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Towards a high-throughput label-free detection system combining localized-surface plasmon resonance and microfluidics

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Dissolution-guided wetting for microarray and microfluidic devices

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Blood separation on microfluidic paper-based analytical devices

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Microfluidic cell volume sensor with tunable sensitivity

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An integrated fiber-optic microfluidic device for detection of muscular force generation of microscopic nematodes

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Lab on a Chip’s top cited papers from 2009 and 2010

To celebrate last month’s release of the 2011 Impact Factors, we are making some of our best content free to access.

The collection brings together the 20 top cited  Lab on a Chip papers from 2009 and 2010.

View the collection here.

All the articles are free to access for a limited time, following a simple registration for individual users.

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A message from the Optofluidics 2012 organizers

Dear Colleagues,

Optofluidics 2012 will be held in Suzhou on 13-14 September 2012. The deadline for abstract submission has been extended to 1 August 2012.

This year’s meeting will see more than 20 speakers presenting world-class research in the field of optofluidics. The meeting will not only focus on the latest research impacts in optofluidics, but will also explore multi-disciplinary research between optofluidics with basic science and high potential applications such as biomedical devices, the environment and energy, etc.

All conference papers will be considered for publication in the themed issue on Optofluidics in Lab on a Chip after the meeting.

Looking forward to meeting you in Suzhou,

Dr Albert Yu Bai, Co-Chair (Local Organizer)
Dr Li Ming Sun, Co-Chair (Local Organizer)

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Submicron particle focussing, 3D capillary networks & monitoring cell signalling in Issue 16

We’ve got some great artwork on the covers of Issue 16,  on topics from particle focusing to creating 3D capillary networks and cell signalling.

Lateral migration and focusing of colloidal particles and DNA molecules under viscoelastic flowOn the outside front cover we have a HOT article from Ju Min Kim et al who have achieved viscoelasticity-driven focusing of particles as small as 200 nm – a technique which had previously only been achieved with micron-sized particles.  The team also showed that DNA focusing is significantly enhanced by medium viscoelasticity and that the focussing of both the colloidal particles and DNA is dependant on length.

Lateral migration and focusing of colloidal particles and DNA molecules under viscoelastic flow
Jae Young Kim, Sung Won Ahn, Sung Sik Lee and Ju Min Kim
DOI: 10.1039/C2LC40147A

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devicesOn the inside front cover is another HOT article from Noo Li Jeon and colleagues at Seoul University who have designed a 3D array of perfusable capillaries from HUVECs.  The the capillary network can be grown on the microfluidic device in 3-4 days and the authors hope will not only be useful for basic angiogenesis research but also drug screening applications.

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices
Ju Hun Yeon, Hyun Ryul Ryu, Minhwan Chung, Qing Ping Hu and Noo Li Jeon
DOI: 10.1039/C2LC40131B

Microfluidically-unified cell culture, sample preparation, imaging and flow cytometry for measurement of cell signaling pathways with single cell resolutionLast but not least, on the back cover is research from Anup Singh and colleagues at Sandia National Laboratory who have developed a chip that enables dynamic monitoring of an entire cell signalling pathway in a single experiment, by combining cell culture, stimulation, and preparation for analysis by multicolor flow cytometry and fluorescence imaging in one device.

Microfluidically-unified cell culture, sample preparation, imaging and flow cytometry for measurement of cell signaling pathways with single cell resolution
Meiye Wu, Thomas D. Perroud, Nimisha Srivastava, Catherine S. Branda, Kenneth L. Sale, Bryan D. Carson, Kamlesh D. Patel, Steven S. Branda and Anup K. Singh
DOI: 10.1039/C2LC40344G

As with all our cover articles these are free to access for 6 weeks (following a simple registration for an RSC Publishing account).

For more exciting miniaturisation research take a look at the rest of the issue

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Our content, straight to your inbox

Did you know that following a simple sign up, you could receive our table-of-contents e-alerts straight to your inbox? Once subscribed, you’ll receive your requested journals’ alerts each issue, meaning that you’ll never miss important research again!

Register today, and receive notification of great content like the below, quickly and easily.

Paper
A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells
Joo H. Kang, Silva Krause, Heather Tobin, Akiko Mammoto, Mathumai Kanapathipillai and Donald E. Ingber
Lab Chip, 2012,12, 2175-2181
DOI: 10.1039/C2LC40072C

Critical Review
Commercialization of microfluidic point-of-care diagnostic devices
Curtis D. Chin, Vincent Linder and Samuel K. Sia
Lab Chip, 2012,12, 2118-2134
DOI: 10.1039/C2LC21204H

Communication
“Fluidic batteries” as low-cost sources of power in paper-based microfluidic devices
Nicole K. Thom, Kimy Yeung, Marley B. Pillion and Scott T. Phillips
Lab Chip, 2012,12, 1768-1770
DOI: 10.1039/C2LC40126F

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HOT article: Ion diode logics for pH control

This week’s HOT article is by Magnus Berggren and co-workers at Linköping University, Sweden. The paper presents three different designs of micro-fabricated ion bipolar membrane diodes (IBMDs), which the authors demonstrate overcoming some of the problems of traditional fast switching ion diodes, such as accumulation of ions inside the device structure.

The first two designs are bipolar membranes which are capable of either splitting water or providing high current rectification. The third design incorporates the previous two, connecting the bipolar membranes in series, meaning that suppression of ion accumulation is achieved.

Ion diode logics for pH control
Erik O. Gabrielsson, Klas Tybrandt and Magnus Berggren
DOI: 10.1039/C2LC40093F

This HOT article is free to access for the next four weeks following a simple registration for individual users.

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New YouTube videos

View the new videos on the Lab on a Chip YouTube site using the links below:

Electro-optical BLM chips enabling dynamic imaging of ordered lipid domains

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Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography

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Direct-writing colloidal photonic crystal microfluidic chips by inkjet printing for label-free protein detection

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Unveiling the missing transport mechanism inside the valveless micropump

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Construction of multifunctional photonic crystal microcapsules with tunable shell structures by combining microfluidic and controlled photopolymerization

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Inverted open microwells for cell trapping, cell aggregate formation and parallel recovery of live cells

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Microfluidic sorting of arbitrary cells with dynamic optical tweezers

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III International Workshop on Analytical Miniaturization and NANOtechnologies

LOC recently published a themed issue on nanomaterials and technologies for lab on a chip applications in collaboration with WAM-NANO2012 – the III International Workshop on Analytical Miniaturization and NANOtechnologies.

The conference was held last month in Barcelona, and below Arben Merkoçi provides a short summary of the meeting:

III International Workshop on Analytical Miniaturization and NANOtechnologiesThe “III International Workshop on Analytical Miniaturization and NANOtechnologies (WAM-NANO2012)” was held in Barcelona, Spain on 11 and 12 June 2012. The event, organised by the Catalan Institute of Nanotechnology (ICN), highlighted the latest international developments in the use of nanotechnologies and nanomaterials for the design and applications of lab-on-a-chip (LOC) systems and other miniaturised analytical (bio)systems. The workshop, together with a themed issue of Lab-on-a-Chip, entitled “Nanotechnologies and nanomaterials in lab-on-a-chip”, reported on the most important achievements in analytical miniaturisation, where nanotechnology is positioned to enable great advances.

WAM-NANO2012 drew 85 participants from a dozen countries and featured 19 talks by invited speakers, 42 posters, and exhibits by three companies in the field (Fluigent, MicruX Technologies and Invenios). The event began with an opening presentation by Workshop Director Prof Arben Merkoçi, who heads the Nanobioelectronics and Biosensors Group at ICN.

Invited speakers at WAM-NANO2012:

Yoshinobu Baba (Dept. Applied Chemistry, Nagoya University, Japan)
Nanobiodevice-based single biomolecule and cell analysis for cancer diagnosis and stem cell therapy

Emanuel Carrilho (Bioanalytical, Microfabrication and Separations Group, Instituto de Química de Sao Carlos/ Universidade de Sao Paulo, Instituto Nacional de Ciencia e Tecnologia de Bioanalitica, Sao Carlos Brasil)
New strategies for contactless conductivity detection in microfluidic systems and electrophoresis

Agustín Costa García (University of Oviedo, Spain)
Nanotechnological approaches for improvement of microchip electrophoresis devices

Emmanuel Delamarche (IBM Zurich Research Laboratory, Switzerland)
Miniaturized assays using capillary-driven microfluidics

Tatsuro Endo (Analytical Chemistry research Group, Department of Applied Chemistry, Osaka Prefecture University, Japan)
Printed two dimensional photonic crystal for single step label-free biosensor

Alberto Escarpa (University of Alcalà, Spain)
High NIR-purity index single-walled carbon nanotubes for electrochemical sensing in microfluidic chips

Carlos García (University of Texas at San Antonio, USA)
Microchips, robots, and nanomaterials: novel strategies for the analysis of biologically active compounds

Akihide Hibara (Institute of Industrial Science, The University of Tokyo, Tokyo, Japan)
Chemistry and physics of liquid interfaces in microfluidic devices

Alexander Kuhn (ENSCBP, University of Bordeaux, France)
Bipolar electrochemistry in microfluidic channels

Jörg P. Kutter (DTU Nanotech, Department of Micro- and Nanotechnology, Technical University of Denmark, Denmark)
Carbon nanotubes for applications in miniaturized separation systems

Laura Lechuga (Centre d’Investigacions en Nanociencia i Nanotecnologia, CIN2 (CSIC-ICN), Barcelona, Spain)
Photonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers

Arben Merkoçi (Institut Català de Nanotecnologia, ICN, Barcelona, Spain)
Nanoparticles based microfluidics (bio)sensing

Bradley J. Nelson (Institute of Robotics and Intelligent Systems, ETH Zurich, Switzerland)
Fabrication and magnetic actuation of polymer helical microswimmers coated with a soft magnetic film

Mar Puyol (Dept. Chemistry, Autonomous University of Barcelona, Spain)
Microfluidic platforms for nanoparticles synthesis and bioanalytical sensing

Johan Roeraade (Dept. Analytical Chemistry, Royal Institute of Technology, Sweden)
New miniaturized technologies for mass spectrometry of biomolecules

Oliver Schmidt (Leibniz Institute for Solid State and Materials Research (IFW) Dresden, Germany)
Rolled-up nanotech for lab-in-a-tube systems and microjet engines

Albert Van der Berg (University of Twente, Twente, The Netherlands)
Labs on a chip for medical applications

Jean-Louis Viovy (Macromolecules and microsystems in biology and medicine (MMBM), Institute Curie, Paris, France)
Neuron arrays on chip to study neurodegenrative diseases

Joseph Wang (Dept. Nanoengineering, University of California, San Diego (UCSD), USA)
Nanomotor-based biosensing: towards nanomachine-based lab-on-chips

View the whole issue here

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Top ten most accessed articles in May

This month sees the following articles in Lab on a Chip that are in the top ten most accessed:

Microengineered physiological biomimicry: Organs-on-Chips
Dongeun Huh, Yu-suke Torisawa, Geraldine A. Hamilton, Hyun Jung Kim and Donald E. Ingber
Lab Chip, 2012, 12, 2156-2164
DOI: 10.1039/C2LC40089H

Lab on a Chip: United States of America
Donald E. Ingber and George M. Whitesides
Lab Chip, 2012, 12, 2089-2090
DOI: 10.1039/C2LC90052A

Integrated rapid-diagnostic-test reader platform on a cellphone
Onur Mudanyali, Stoyan Dimitrov, Uzair Sikora, Swati Padmanabhan, Isa Navruz and Aydogan Ozcan
Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC40235A

High-throughput immunoassay through in-channel microfluidic patterning
Chunhong Zheng, Jingwen Wang, Yuhong Pang, Jianbin Wang, Wenbin Li, Zigang Ge and Yanyi Huang
Lab Chip, 2012, 12, 2487-2490
DOI: 10.1039/C2LC40145B

Microfluidic synthesis of multifunctional Janus particles for biomedical applications
Shikuan Yang, Feng Guo, Brian Kiraly, Xiaole Mao, Mengqian Lu, Kam W. Leong and Tony Jun Huang
Lab Chip, 2012, 12, 2097-2102
DOI: 10.1039/C2LC90046G

Commercialization of microfluidic point-of-care diagnostic devices
Curtis D. Chin, Vincent Linder and Samuel K. Sia
Lab Chip, 2012, Advance Article
DOI: 10.1039/C2LC21204H

Contributors to the USA issue
Lab Chip, 2012, 12, 2091-2093
DOI: 10.1039/C2LC90053J

Diagnostic microchip to assay 3D colony-growth potential of captured circulating tumor cells
Colette A. Bichsel, Samy Gobaa, Stefan Kobel, Chiara Secondini, George N. Thalmann, Marco G. Cecchini and Matthias P. Lutolf
Lab Chip, 2012, 12, 2313-2316
DOI: 10.1039/C2LC40130D

Microfluidic approaches for cancer cell detection, characterization, and separation
Jian Chen, Jason Li and Yu Sun
Lab Chip, 2012, 12, 1753-1767
DOI: 10.1039/C2LC21273K

Microfluidic Apps for off-the-shelf instruments
Daniel Mark, Felix von Stetten and Roland Zengerle
Lab Chip, 2012, 12, 2464-2468
DOI: 10.1039/C2LC00043A

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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