The 16th biennial meeting for the Society for Free Radical Research International (SFRRI)

The 16th SRRRI Biennial Meeting will be held at Imperial College London, UK, between the 6th-9th September 2012.  This meeting will be a premier forum for the latest advancements in free radical research.

The meeting will include morning plenary lectures, followed by afternoon parallel themed sessions as well as early evening poster presentations.  Symposium 2 on Phytochemicals (Micronutrients) in Redox Signalling (Clore) is being held on the morning of the 6th September and is Chaired by Food & Function Associate Editor Professor Cesar Fraga (University of Buenos Aires, Argentina) alongside Professor Helmut Sies (Heinrich-Heine-University Duesseldorf, Germany).  Invited speakers include: Professor Young-Joon Surh, Professor Patricia Oteiza, Dr Francisco Villarreal and Professor Jeremy Spencer.

Register for this meeting now, or visit the website for further information.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

A new method to assess the radical scavenging activity of carotenoids

Carotenoids, highly pigmented compounds found in various foods such as carrots, tomatoes and apricots, have received a lot of attention recently due to their natural antioxidant properties. Because of their highly conjugated polyene structures these compounds act as singlet oxygen quenchers and radical scavengers and play an important role in the prevention of oxidative stress, which in turn prohibits the pathogenesis of various diseases. However, unlike phenolic antioxidants, carotenoids do not have a reactive hydrogen to donate to a radical, which makes it difficult for conventional probes to assess the radical scavenging capacity of these compounds. Therefore a deeper understanding of the radical scavenging mechanism is required.

In this work, scientists from Osaka, Japan, have investigated the radical scavenging capacity of commercial tomato juice and two major carotenoids (b-carotene and lycopene). By taking into account the strong light absorption of carotenoids in the visible spectrum the authors developed a technique using the bleaching of carotenoids by free radicals in the presence of a reference antioxidant, a-tocopherol. Their results show that the free-radical scavenging activity of carotenoids is aproximately a tenth of a-tocopherol in model systems and commercial tomato juice.

Read the full article for free until 11th September by clicking the link below:

Capacity of peroxyl radical scavenging and inhibition of lipid peroxidation by b-carotene, lycopene, and commercial tomato juice, Mizuki Takashima, Mototada Shichiri, Yoshihisa Hagihara, Yasukazu Yoshida and Etsuo Niki, Food Funct., 2012, DOI: 10.1039/C2FO30119A.

You may also be interested in the following article published in Food & Function earlier this year:

Xanthones as antioxidants: A theoretical study on the thermodynamics and kinetics of the single electron transfer mechanism, Ana Martínez, Elizabeth Hernández-Marin and Annia Galano, Food Funct., 2012, 3, 442-450

You can keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and monthly e-newsletters.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Long life rice

Black rice is rich in antioxidants

Antioxidants in black rice have prolonged the life of fruit flies by 14%, say scientists from China.

Antioxidants inhibit the effects of reactive oxygen species in the body, which attack cells and are responsible for ageing. Black rice, rich in antioxidants and widely consumed in China, is associated with a reduction in the risk of cancer, heart disease, diabetes and Alzheimer’s disease. It’s also been claimed to possess anti-ageing activity. Zhen-Yu Chen and colleagues from The Chinese University of Hong Kong fed antioxidants in black rice extract to fruit flies and observed that the flies lived longer than they normally would. Their mean lifespan increased from 44 days to 50 days…

Read the full article in Chemistry World.

Link to journal article

Black Rice Extract Extends the Lifespan of Fruit Flies, Yuanyuan Zuo, Cheng Peng, Yintong Liang, Ka Ying Ma, Hongjian Yu, Ho Yin Edwin Chan and Zhen-Yu Chen, Food Funct., 2012, DOI: 10.1039/C2FO30135K

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Quercetin metabolite affects macrophage gene expression resulting in anti-inflammatory activity

In this study the effect of a major quercetin metabolite on gene expression of macrophages was investigated to elucidate the molecular mechanism behind the beneficial effects of flavonoids on cardiovascular disease. Macrophages (white blood cells within tissues), due to their recently discovered plasticity, are thought to play a crucial role in the development of atherosclerosis and quercetin has been implicated in inflammation modulation in humans through mechanisms involving macrophages. 

In this work classical (M1) and alternative (M2a) macrophages were exposed to quercetin-3-O-glucuronide (Q3GA – the main human metabolite of the flavonoid quercetin) and gene expression was monitored after an incubation period. Q3GA was able to reduce the transcription of genes from M2a macrophages involved in inflammation showing that Q3GA positively influences inflammation-related gene expression in macrophages at low concentration. Also, as quercetin is a flavonoid, the observations reported in this work could explain the previously observed anti-atherogenic effects of diets rich in flavonoids.

To read the article for free until 4th September, please click the link below:

Quercetin-3-O-glucuronide affects the gene expression profile of M1 and M2a human macrophages exhibiting antiinflammatory effects, Eleonora Derlindati, Margherita Dall’Asta, Diego Ardigo, Furio Brighenti, Ivana Zavaroni, Alan Crozier and Daniele Del Rio, Food Funct., 2012, DOI: 10.1039/c2fo30127j

You may also be interested in this review which is also FREE to access:

Anti-inflammatory activity of natural dietary flavonoids, Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho, Food Funct., 2010,1, 15-31

You can keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and monthly e-newsletters.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Interview with Nissim Garti: Function is Everything

Nissim Garti, Editorial Board Member of Food & Function, talks to Anna Simpson about links between industry and academia, liquid delivery systems, what the term food and function means to him and about an interesting hobby.

Nissim Garti Nissim Garti is full professor of Chemistry at The Hebrew University of Jerusalem and is incumbent of the Ratner Chair of Chemistry. He has published over 400 peer-reviewed manuscripts, written 80 review chapters, edited 6 books, and holds 90 patents. Professor Garti has received national and international awards, including the AOCS Chang Award, the Rockefeller Award, the IFT Award (2008), and Life Time Achievement Award (2009). Recently Professor Garti’s second (modified LLCs) invention was included in the Hall of Fame of The Hebrew University. The Food Society of Israel awarded him a Lifetime Achievement Award. 

How did you become interested in food science research?

My father owned a wholesale foods outlet.  When I went to university I started at medical school but after a few weeks I decided I did not want to be a medical doctor so I changed to chemistry.  I followed my degree with a Masters in food and the rest is history; although I don’t only do food, these days a third of my work is pharmaceuticals.

You have strong links with industry; what are your views on how industry and academia can work together?

I think they must work together.  My department is called the school of applied product-oriented research so applications are always a focus of work.  My Masters students do the applied research while PhD students perform fundamental research.  I only publish the fundamental research, the rest goes into patents.  I have over 90 patents and have been involved in a few start-ups.

Could you tell us more about the Nano-sized Self-assembled Structured Liquids (NSSL) technology that is behind your start-up company NutraLease?

NSSLs are a form of modified microemulsion.  They have been known for a long time, since the fifties, but the problem was that when they were diluted they broke apart.  Our development allowed them to be diluted so when they are taken into the body and diluted during digestion they stay in-tact; they are also adsorbed onto the lumen and release their contents.

What is the main focus of your research at the moment?

I am interested in all new liquid delivery systems.  I always focus on new ways of entrapment and am interested in developing novel systems.  I am currently very interested in lyotropic liquid crystals as solubilisation vehicles.

What does the term Food & Function mean to you?

Well, function is everything.  Functionality is all about what something does, and to me, this has to be about new functions or unexpected functions; it is not interesting to present a function that would be expected.  For example, if combining protein and vitamin A resulted in a new function, such as increased bioavailability, this would be a new functionality.  So, to me, what is interesting is discovering an unexpected function, or designing a new structure which provides a new functionality, or altering the function of a known substance; these are more interesting than understanding how something works.

Could you tell us a bit about your interests outside of science

My hobby is photography.  I travel to very remote places and meet with isolated tribes that are dying from existence, known as ‘disappearing tribes’.  I am not just interested in photos as a visual record; I go with a small group and get to know the people.  I am interested in their culture and customs, the way they do things, live and have fun.  We spend time with them and build trust and only then will I take photographs, when they know me and trust me.

Also of Interest

Read Professor Garti’s recently published review in Food & Function:

Lipid polymorphism in lyotropic liquid crystals for triggered release of bioactives
Nissim Garti,  Dima Libster and Abraham Aserin, Food Funct., 2012,3, 700-713

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Food & Function issue 8 – now online

The latest issue of Food & Function is now available online!

The front cover of this issue features work by Gregory Monteith and colleagues from The University of Queensland, Australia, who have found that chemicals in the peel of some mango varieties, but not the flesh, contain certain chemicals which prevent the formation of fat cells (adipogenesis).  The authors suggest that the pathways involved in this inhibition of adipogenesis may be similar to those of resveratrol.  These results show that phytochemical differences in composition and/or quantity across cultivars can have a big impact on adipogenesis.

Read the full article here – free to access for 6 weeks

You can keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and monthly e-newsletters.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

The OCC world congress – ‘Oxidants and Antioxidants in Biology’

The world congress “Oxidants and Antioxidants in Biology” was held in Alba, Italy, 20th-23rd June 2012. It was a joint meeting of the Oxygen Club of California (OCC) and the University of Turin, Italy, co-sponsored by the Linus Pauling Institute, Oregon State University, U.S.A. This congress is part of a serial of congresses organized every other year by the OCC that gather highly recognized scientists in areas that convey basic and applied medical research.

Guliz Armagan receiving her certificate from Food & Function Associate Editor, Professor Cesaer Fraga

This year, the subject of the meeting was “Cell signaling and nutrient-gene interactions,” having sessions on NRF2-driven regulation of antioxidant defenses, nutrient-gene interactions and epigenetics, novel roles of micronutrients, lipid oxidation and signaling, and epigenetics, metabolism, and aging. The Congress had an attendance of 220 delegates from all over the world, including speakers and chairpersons, general attendants, and young scientists.

Selected from about one hundred presentations 4 Young Investigator prizes were given. The selection was done based on the quality of the work and the proficiency of the presenter by a committee of 6 senior scientists (including: John Maguire, Berkeley; Emily Ho, Corvalis; Josiane Cillard, Rennes; and Nesrin Ozer, Istambul).

Food & Function and the Royal Society of Chemistry awarded a prize for the best work in the area of Nutrition to Guliz Armagan from the Department of Biochemistry, School of Pharmacy, Ege University, Izmir, Turkey. The work, “Induction of oxidative stress, apoptosis and inflammation in rat brain regions by D-serine” was co-authored by Lutfiye Kanit, and Ayfer Yalcin from the same University.  Many congratulations to Guliz on winning this prize.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Top ten most accessed articles in June

This month sees the following articles in Food & Function that are in the top ten most accessed:-

Nuts, especially walnuts, have both antioxidant quantity and efficacy and exhibit significant potential health benefits
Joe A. Vinson and Yuxing Cai
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO10152A

Anti-inflammatory activity of natural dietary flavonoids
Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho
Food Funct., 2010,1, 15-31, DOI: 10.1039/C0FO00103A, Review Article

Effects of tea and coffee on cardiovascular disease risk
Siv K Bøhn, Natalie C Ward, Jonathan M Hodgson and Kevin D Croft
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO10288A

Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells
Meng-Wong Taing, Jean-Thomas Pierson, Van L. T. Hoang, Paul N. Shaw, Ralf G. Dietzgen, Michael J. Gidley, Sarah J. Roberts-Thomson and Gregory R. Monteith
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO30073G, Paper

Review of in vitro digestion models for rapid screening of emulsion-based systems
David Julian McClements and Yan Li
Food Funct., 2010,1, 32-59, DOI: 10.1039/C0FO00111B, Review Article

Recent developments on polyphenol-protein interactions: effects on tea and coffee taste, antioxidant properties and the digestive system
Prasun Bandyopadhyay, Amit K. Ghosh and Chandrasekhar Ghosh
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO00006G

Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds
Wasaporn Chanput, Jurriaan Mes, Robert A. M. Vreeburg, Huub F. J. Savelkoul and Harry J. Wichers
Food Funct., 2010,1, 254-261, DOI: 10.1039/C0FO00113A

Development of oral food-grade delivery systems: Current knowledge and future challenges
Revital Cohen Benshitrit, Carmit Shani Levi, Sharon Levi Tal, Eyal Shimoni and Uri Lesmes
Food Funct., 2012,3, 10-21, DOI: 10.1039/C1FO10068H, Review Article

Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites
Maria Monagas, Mireia Urpi-Sarda, Fernando Sánchez-Patán, Rafael Llorach, Ignacio Garrido, Carmen Gómez-Cordovés, Cristina Andres-Lacueva and Begoña Bartolomé
Food Funct., 2010,1, 233-253, DOI: 10.1039/C0FO00132E, Review Article

Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs)
Rudy Simons, Harry Gruppen, Toine F. H. Bovee, Marian A. Verbruggen and Jean-Paul Vincken
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO10290K, Review Article

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Food & Function? Then why not submit to us today or alternatively email us your suggestions.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Bittersweet result for dark chocolate

 

Studies show that polyphenol-rich dark chocolate has health benefits for overweight females

Studies show that polyphenol-rich dark chocolate has health benefits for overweight females

UK scientists have clinically proven that consuming polyphenol-rich dark chocolate has health benefits for overweight and obese females, whilst showing adverse effects for polyphenol-deficient chocolate.

Evidence already shows that polyphenol-rich dark chocolate can benefit blood pressure and glucose levels in healthy people, thanks to dark chocolate’s antioxidant properties. Fewer studies have examined the involvement of the endocrine system – glands that secrete hormones – in mediating the cardiometabolic health-effects of polyphenols, until now.

Suzana Almoosawi from Medical Research Council Human Nutrition Research, Cambridge, and the Queen Margaret University, Edinburgh and her colleagues, applied these findings to a group of healthy women with a range of body mass indexes (BMIs). Obesity is often linked to numerous chronic diseases, such as hypertension and type 2 diabetes, so the team were keen to study the metabolic effects observed for different concentrations of polyphenols in dark chocolate, across a range of BMIs.

Read the full article in Chemistry World

Link to journal article
Differential effect of polyphenol-rich dark chocolate on biomarkers of glucose metabolism and cardiovascular risk factors in healthy, overweight and obese subjects: a randomized clinical trial
S Almoosawi et al
Food Funct., 2012, DOI: 10.1039/c2fo30060e

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Mechanism explaining neuroprotective effects of citrus flavonoids revealed

C2FO30100HThe mechanism of pro-cellular survival and neuroprotective actions of hesperetin in PC12 cells has been elucidated by Gow-Chin Yen and co-workers in Taiwan.

Hesperidin is one of the most abundant flavonoids found in citrus fruits, in particular oranges, tangerines and lemons.  Although only a moderate anti-oxidant, studies have demonstrated that hesperetin protects neural cells against oxidative damage. Previous work by the Taiwanese team has demonstrated that hesperetin acts more as a signalling modulator than an antioxidant and protects against oxidative stress via  estrogen recptor (ER) and tyrosine kinase receptor A (TrkA) mediated actions.

In this study the team investigate the more detailed hesperetin-triggered signalling pathways revealing that the parallel pathways collaborate to induce proteins regulated by different transcriptional factors.  The elucidation of this novel mechanism explains why hesperetin, although possessing relatively low antioxidant and estrogen activities, can exhibit multiple neuroprotective effects.

Interested in knowing more details? Read the article in full for free until 10th August.

Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells
Sam-Long Hwang, Jer-An Lin, Ping-Hsiao Shih, Chi-Tai Yeh and Gow-Chin Yen
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO30100H

You may also be interested in this review which is also free to access

Anti-inflammatory activity of natural dietary flavonoids, Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho
Food Funct., 2010,1, 15-31, DOI: 10.1039/C0FO00103A

You can keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and monthly e-newsletters.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)