The ligand, 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone, is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center to form a 1D polymeric unit.
Karuppannan Natarajan and colleagues have synthesised and characterised the Co(II) complex, {[Co(H2L)(H2O)2](NO3)2·3H2O}n. Human cancer cytotoxicity studies have shown the complex is very specific for cancer cells and less toxic in comparison to the well-know cancer drug, cisplatin.
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A novel water soluble ligand bridged cobalt(II) coordination polymer of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone: evaluation of the DNA binding, protein interaction, radical scavenging and anticancer activity
Duraisamy Senthil Raja, Nattamai S. P. Bhuvanesh and Karuppannan Natarajan
Dalton Trans., 2012
DOI: 10.1039/C2DT12274J
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