In their recent PCCP Perspective, Maxim Prigozhin and Martin Gruebele from the Center for Biophysics and Computational Biology, Urbana, USA, provide an excellent overview of the recent developments in the area of protein folding on the microsecond timescale.
Their Perspective compares recent experiments and simulations that have progressed the understanding of complex problems of multiple reaction coordinates, downhill folding, and intricate underlying structures of unfolded or misfolded states.
Advances in computing power and force fields in the late 1990s made it possible to directly compare protein folding experiments and simulations on the microsecond time-scale. Since then, understanding of how small globular proteins fold has made much progress.
With the continuing developments in both computing power and experimental methodology, this article highlights that exciting things in protein science are still to come!
Read this Perspective today:
Microsecond folding experiments and simulations: a match is made
M. B. Prigozhin and M. Gruebele
DOI: 10.1039/C3CP43992E
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