The incorporation of hematoporphyrin IX (Hp IX) in silica nanospheres enhances its potential for photodynamic therapy.
The entrapment of Hp IX in silica by means of a microemulsion resulted in silica spheres of 33 ± 6 nm. The small size, narrow size distribution and lack of aggregation maintain Hp IX silica nanospheres stable in aqueous solutions for long periods and permit a detailed study of the entrapped drug by different techniques.
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Enhancement of hematoporphyrin IX potential for photodynamic therapy by entrapment in silica nanospheres
Paulo R. Silva, Lucas L. R. Vono, Breno P. Espósito, Maurício S. Baptista and Liane M. Rossi
Phys. Chem. Chem. Phys., 2011, DOI: 10.1039/C1CP21525F
