CrystEngComm Blog

Guanidinium-based building blocks

29 Nov 2012

This article is HOT as recommended by the referees. And we’ve made it free to access for 4 weeks.

Guanidinium-based synthons are useful for building ordered supramolecular structures due to their large number of charge-assisted hydrogen bonds (the guanidinium cation has 6 active H bonds). However, due to this plethora of potential intermolecular interactions, it can be a tricky to predict and design resultant structures – which is what crystal engineering is all about…

In their latest CrystEngComm Communication, Yadav and Gorbitz have endeavoured to restrict the modes of hydrogen bonding by substituting with TBD (see below). TBD has only 2 N-H donors which is much more manageable for these purposes! They partnered the TBD with dicarboxylic acid, 2,2′-bipyridine-5,5′ dicarboxylic acid (BPDA) to form a 2:1 complex. Additional acceptor sites at the carboxylate lone pairs means that 4 water molecules can co-crystallise along with the structure, leading to extended water channels or open organic networks containing clusters of water.

Read more now…

A supramolecular 2:1 guanidinium–carboxylate based building block for generation of water channels and clusters in organic materials
Vitthal N. Yadav and Carl Henrik Görbitz
CrystEngComm, 2013, DOI: 10.1039/C2CE26572A

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November Crystal Clear: Seeing Red

23 Nov 2012

By Matthew Cude, Development Editor.

Mid-infrared lasers are of particular interest for a variety of applications including sensing, defence applications and laser surgery tools such as the laser scalpel.

This month’s crystal clear is a very bright image of a CaErAlO₄ crystal.

The team from the Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, led by Professor Chaoyang Tu have been investigating new materials for mid-infrared lasers. Lasers in this range of the spectrum are of particular interest for a variety of applications including sensing, defence applications such as heat seeking missile counter measures and laser surgery tools such as the laser scalpel.

The crystal was successfully grown using the Czochralski method and the absorption and emission properties compared to those of existing InGaAs laser diodes and Er:YAG lasers. For more details on the team’s research findings, including the photochemical properties and crystal structure, you can read the full article which was published in Issue 21 of CrystEngComm.

Growth, structure and spectral properties of a novel crystal CaErAlO₄ for 2.7 μm lasers
Zhaojie Zhu, Huiyi Zeng, Jianfu Li, Zhenyu You, Yan Wang, Zixiang Huang and Chaoyang Tu
CrystEngComm, 2012, 14, 7423-7427
DOI: 10.1039/C2CE26013A

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Polymorphism co-crystal screening

15 Nov 2012

By Helen Lunn, Publishing Editor.

This article is HOT as recommended by the referees. And we’ve made it free to access for 4 weeks.

In their HOT article, Jones and co-workers at the University of Cambridge present a comprehensive crystal form screen for the phenazine:mesaconic acid system, employing a variety of different co-crystallisation methods.

: Phenazine:mesaconic acid system

The researchers identified and characterised three anhydrous co-crystal polymorphs, one co-crystal hydrate and one DMSO co-crystal solvate, and also highlighted a novel co-crystallisation technique at the interface between two immiscible solutions, yielding a pure phenazine:mesaconic acid co-crystal form. Traditional solvent-based methods usually used for polymorphism screening were inappropriate for this system due to the large differences in solubility of phenazine and mesaconic acid.

Role of aspartic acid in regulating the growth of common kidney stones

13 Nov 2012

By Jennifer Newton, Publishing Editor.

This article is HOT as recommended by the referees. And we’ve made it free to access for 4 weeks.

Yu Huang, S. Roger Qiu and colleagues have used in situ atomic force microscopy to investigate how the growth of calcium oxalate monohydrate is inhibited by 6-residue linear aspartic acid peptides.

Analysis of the step speed data showed that the aspartic acid enantiomers block active kink sites through step-pinning.

Calcium oxalate monohydrate is the main inorganic component in the most common types of kidney stones, so preventing their formation is of great clinical importance.

October Crystal Clear: A Sparkling Crystal

31 Oct 2012

By Matthew Cude, Development Editor.

This month’s crystal clear is a barium borate crystal.

Inorganic borates are of interest due to their physical properties in the ultraviolet range of the electromagnetic spectrum, making them potentially useful materials in non-linear optics. The image is of a crystal created by T. B. Bekker et al from the Siberian Branch of Russian Academy of Sciences and published in Issue 20 of CrystEngComm.

The team were studying the BaB₂O₄–BaF₂–BaO system and discovered the new non-centrosymmetric solid-solution series Ba₇(BO₃)_4−xF_2+3x. For more information on the group’s discoveries you can download the full paper which is free to access for 4 weeks.

Phase formation in the BaB₂O₄–BaF₂–BaO system and new non-centrosymmetric solid-solution series Ba₇(BO₃)_4−xF_2+3xT. B. Bekker, S. V. Rashchenko, V. V. Bakakin, Yu. V. Seryotkin, P. P. Fedorov, A. E. Kokh and S. Yu. Stonoga
CrystEngComm, 2012, 14, 6910-6915
DOI: 10.1039/C2CE26122G

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Kari Rissanen talks with CrystEngComm

26 Oct 2012

By Claire Murray, Web Writer.

Kari Rissanen

Professor Kari Rissanen is an Academy Professor at the Academy of Finland, where he is currently on leave from the University of Jyväskylä. He was first elected as Associate Professor of Organic Chemistry at University of Joensuu after completing his PhD in chemistry at the University of Jyväskylä.

His main interests lie in the fields of supramolecular chemistry, nanochemistry and X-ray crystallography, with a particular focus on weak intermolecular interactions in solid state materials, solutions and gaseous phases. His group are currently working on new self-organising organic nanoreactors, utilising combinations of metal coordination or halogen bonding, and halogen-bonded and organic two- or three-dimensional frameworks.

Here he talks with CrystEngComm about his first crystal structure, and his many projects in the field of supramolecular chemistry.

Why did you want to become a scientist?

I have been always interested in natural sciences, especially chemistry, and at best scientific research can be like detective work.

What projects are you working on at the moment?

My research is primarily based around the following Academy of Finland funded projects:

• Self-assembly of nano-sized supramolecular assemblies
• Functional materials by metal-directed self-assembly
• Supramolecular complexes and networks – design, photocontrol and function
• Intramolecular charge transfer (ICT) based fluorescent probes for monitoring zinc(II) and anions in gold nanoparticles
• New water-soluble chemo-responsive luminescent materials
• Weak interactions as structural elements in self-assembling molecular systems

What do you think will be the next big breakthrough in your field?

The full utilization of the sub-component self-assembly principle (pioneered by Jonathan Nitschke, Cambridge, UK).

How do you think Crystal Engineering will develop in the next couple of years?

To the understanding and utilization of the hierarchical order of multiple and simultaneously active weak intermolecular interactions.

What is the most rewarding aspect of your work?

I really enjoy being able to help and tutor my students, postdocs and colleagues in resolving their difficult structural problems.

What is the secret to a successful research group?

Motivation and dedication to the research and persistence in overcoming encountered difficulties are all key to the success of a research group.

What achievement are you most proud of?

Winning two consecutive 5-year Academy Professorships – this is the most prestigious scientific research position in Finland.

What advice would you give to a young scientist?

Learn the basics well and keep an open and keen mind to everything new. Focus on your research and try to look it from a different perspective. In case of difficulty seek advice and help from more experienced colleagues and mentors.

What would you do if you weren’t a scientist?

Actually I have never though about this possibility, but maybe some kind of high school teacher?

What is your favourite space group and why?

R-3. Only 4 of my 850 published structures have this space group and in each case this space group has revealed a very interesting structure.

What was your first crystal structure?

Nickel salicylate. This was a product of my M.Sc thesis work which was published in Acta Chemica Scandinavica in 1987.

Read more about Kari’s work in the RSC articles below…

Self-ordering of metallogrid complexes via directed hydrogen-bonding
Artur R. Stefankiewicz, Guillaume Rogez, Jack Harrowfield, Alexandre N. Sobolev, Augustin Madalan, Juhani Huuskonen, Kari Rissanen and Jean-Marie Lehn
Dalton Transactions, 2012, Advance Article

Cooperativity of H-bonding and anion–π interaction in the binding of anions with neutral π-acceptors
Michael Giese, Markus Albrecht, Tim Krappitz, Marius Peters, Verena Gossen, Gerhard Raabe, Arto Valkonen and Kari Rissanen
Chem. Commun., 2012, 48, 9983-9985

Crystal packing of amines and N-haloimides

Interaction between amines and N-haloimides: a new motif for unprecedentedly short Br···N and I···N halogen bonds

Kari Raatikainen and Kari Rissanen

CrystEngComm, 2011, 13, 6972-6977
(Previously highlighted on this blog!)

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H-bonds under pressure

26 Oct 2012

By Helen Lunn, Publishing Editor.

This article is HOT as recommended by the referees. And we’ve made it free to access for 4 weeks.

Crystal growth of aniline-II at 0.8 GPa

In an extension to previous work showing that H-bond lengths are pressure sensitive, Parsons and co-workers used the PIXEL method (a computational method for structural prediction) to study the variation in energy of intermolecular interactions with pressure, in two crystalline phases of aniline.

For aniline II, at a pressure of 7.3 GPa, the pressure-induced shortening of the H-bonds was found to go beyond the Cambridge Structural Database limit with the H-bonds being similar in energy to the CH-π contacts.

This ability to manipulate the hierarchy of intermolecular interactions by high pressure could have potentially important implications in crystal engineering.

Read more for FREE about the use of high pressure in crystalline solids at:

Destabilisation of hydrogen bonding and the phase stability of aniline at high pressure
Nicholas P. Funnell, Alice Dawson, William G. Marshall and Simon Parsons
CrystEngComm, 2012, Advance Article
DOI: 10.1039/C2CE26403J, Paper

You may also want to check out previous work from Simon Parsons:

Alanine at 13.6 GPa and its pressure-induced amorphisation at 15 GPa
Nicholas P. Funnell, William G. Marshall and Simon Parsons
CrystEngComm, 2011, 13, 5841-5848
DOI: 10.1039/C1CE05487B, Paper

The effect of pressure on the crystal structure of L-alanine
Nicholas P. Funnell, Alice Dawson, Duncan Francis, Alistair R. Lennie, William G. Marshall, Stephen A. Moggach, John E. Warren and Simon Parsons
CrystEngComm, 2010, 12, 2573-2583
DOI: 10.1039/C001296C, Paper

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Building MOFs with 3-pyridylisonicotinamide ligands

18 Oct 2012

By Jennifer Newton, Publishing Editor.

This article is HOT as recommended by the referees. And we’ve made it free to access for 4 weeks.

Robert LaDuca, and colleagues at Michigan State University, have hydrothermally synthesised divalent metal coordination polymers featuring the ligand, 3-pyridylisonicotinamide (3-pina). The 3-pina ligand has a hydrogen bonding donor and acceptor locus at its central amide, making supramolecular structure direction achievable, something that is not possible using the regularly tested ligand, 4,4′-bipyridine.

The 3-pyridylisonicotinamide ligand has a kinked disposition of its nitrogen atoms.

The team discuss 3 very diverse structures featuring the 3-pina ligand, showing that the dimensionality in the resulting coordination polymers very much depends on the metal coordination environment and the sulfate binding mode that occurs in each case.

Download the paper now to find out more:

Metal dependent dimensionality in sulfate coordination polymers containing 3-pyridylisonicotinamide
Jacqueline S. Lucas, Jacob W. Uebler and Robert L. LaDuca
CrystEngComm, 2012
DOI: 10.1039/C2CE26333E, Paper

Take a look at some of the teams other recent CrystEngComm articles:

Topological diversity in zinc coordination polymers with 5-substituted isophthalate and bis(4-pyridylmethyl)piperazine ligands
Amy L. Pochodylo and Robert L. LaDuca
CrystEngComm, 2011,13, 2249-2261
DOI: 10.1039/C0CE00715C, Paper

Metal and ligand binding mode dependent topologies in phthalate coordination polymers with bis(4-pyridylformyl)piperazine co-ligands
Curtis Y. Wang, Zachary M. Wilseck, Ronald M. Supkowski and Robert L. LaDuca
CrystEngComm, 2011,13, 1391-1399
DOI: 10.1039/C0CE00632G, Paper

Cadmium bis(4-pyridylformyl)piperazine coordination polymers: layered nets and a novel 3,5-connected binodal lattice
Jacqueline S. Lucas, Amy L. Pochodylo and Robert L. LaDuca
CrystEngComm, 2010,12, 3310-3317
DOI: 10.1039/C0CE00117A, Paper