The authors have also observed ACC nanoparticles of up to
200 nm in liposomes extruded through a 1 mm pore size membrane. Showing no sign of faceting or crystallization, these are the largest ACC nanoparticles stabilized by confinement thus far.
The liposomal encapsulation strategies in combination with in situ imaging, scattering, and spectroscopy will aid in characterizing subsequent phase transformations and polymorph selection in the
nucleation and growth not only of calcium carbonate, but also other (bio)-minerals, pharmaceuticals, and proteins.
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In vitro synthesis and stabilization of amorphous calcium carbonate (ACC) nanoparticles within liposomes
Chantel C. Tester, Ryan E. Brock, Ching-Hsuan Wu, Minna R. Krejci, Steven Weigand and Derk Joester
CrystEngComm, 2011, Advance Article
DOI: 10.1039/C1CE05153A
MOF have been much studied due to their potential applications from their excellent physical and chemical properties, however, many are unlikely to realize their potential due to the expense of the starting materials and/or complexity of the synthesis involved. In this HOT article, Day and co-workers have formed stable cucurbit[5]uril MOF structures as ‘beaded’ rings built on a p-hydroxybenzoic acid template prepared readily by self-assembly as a supramolecular structure that remarkably can be recrystallised from water to form the same stoichiometry and structure as occurs under the initial crystallisation conditions. Accessible channels have clearly been demonstrated for a group of polar volatile organic molecules with significant absorption selectivity for at least three examples.
In this HOT article, scientists from Dublin, Ireland have directed their research towards integrating crystal structure analyses with computational (ab initio) modelling methods and exploring the influence and positional influence of different functional groups e.g. N/F/Cl/Br/I atoms, Me/OMe in semi-rigid drug-like molecules on inter- and intramolecular interactions, conformations and solid-state packing.
anage to keep the growth temperature quite low while still obtaining high quality films, which will be particularly useful for device fabrication.
