Polymorphism in ionic liquids

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Ethambutol dibenzoate trimorphs

Ethambutol dibenzoate trimorphs

Cherukuvada and Nangia report the first example of polymorphism in ionic liquids.  Three polymorphs of ethambutol dibenzoate were crystallized as ionic liquids and characterized.  15N NMR spectroscopy was used to identify the three polymorphs and their stability was investigated with the use of DSC and other experiments.  The polymorphic transformations from forms 1 to 3 were also investigated by PXRD.   Further work on crystallization and characterization will prove useful for new pharmaceutical formulations.

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Polymorphism in an API ionic liquid: ethambutol dibenzoate trimorphs
Suryanarayan Cherukuvada and Ashwini Nangia

CrystEngComm, 2012, Advance Article
DOI: 10.1039/C2CE25842K

Also of interest:

Polymorphs of 1,1-bis(4-hydroxyphenyl)cyclohexane and multiple Z’ crystal structures by melt and sublimation crystallization
Bipul Sarma, Saikat Roy and Ashwini Nangia
Chem. Commun., 2006, 4918-4920
DOI: 10.1039/B610323E, Communication

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