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RSC Chemical Biology Webinar: Outstanding Paper Award Winner 2022

26 Oct 2023

Join us to celebrate the Outstanding Paper Award winners of 2022!

The team at RSC Chemical Biology are delighted to invite you to our upcoming webinar to celebrate the winner of our Outstanding Paper Award from 2022. The winner is Professor Craig Crews, of Yale University, for their paper “OligoTRAFTACs: A generalizable method for transcription factor degradation”.

 

 

 

The webinar, scheduled to last for one hour, will feature a presentation from the group of Professor Craig Crews discussing their work, and this will be followed by a presentation from Professor Michelle Arkin, an Editorial Board Member for RSC Chemical Biology, highlighting some ongoing work in her group at the University of California, San Francisco.

This event is being held online through Zoom and is completely free to attend. It will be held on Tuesday 21st November at 17:00 GMT. You can find more information on our Event Page and can register for the event here.

We look forward to seeing you at the webinar!

 

 

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Celebrating Excellence in Chemical Biology: RSC Chemical Biology Outstanding Paper Award 2022

04 Sep 2023

We are delighted to announce our annual RSC Chemical Biology Outstanding Paper 2022 Award, to recognize some of the outstanding work published in the journal, as well as the authors behind those articles. Selected by our Editorial Board, the winning paper was chosen from a shortlist based on the science presented, and also the potential future impact of the research.

We are thrilled to reveal that the award for 2022 goes to

“OligoTRAFTACs: A generalizable method for transcription factor degradation”

Authors:  Kusal T. G. Samarasinghe, Elvira An, Miriam A. Genuth, Ling Chu, Scott A. Holley, and Craig M. Crews.

RSC Chem. Biol., 2022,3, 1144-1153
DOI 10.1039/D2CB00138A

 

This paper represents a significant leap forward in the field of chemical biology. It introduces a novel method, OligoTRAFTACs, which provides an approach for targeted transcription factor degradation. We reached out to the winning team, and they shared their thoughts on receiving this prestigious award. In their words, “We are honoured and pleased to receive the 2022 RSC Chemical Biology Outstanding Paper Award. We thank the editorial board members for recognizing our work on developing oligoTRAFTACs for targeted transcription factor degradation. Targeted protein degradation has been widely explored in academia and industry, and many degraders are already found their way to the clinic. We believe that progressive innovation of proximity-inducing modalities will contribute to expanding the targeted protein degradation and beyond. This recognition highlights the importance of such developments, and it will undoubtedly impel the research community to further advance the chemical biology field.”

Furthermore, we are excited to announce that the winning team will be presenting their research in a webinar series scheduled for October, with the date to be defined. This will be a unique opportunity to delve deeper into their ground-breaking work and engage with the authors directly.

Meet the authors

 

Let’s take a moment to get to know the authors behind this exceptional paper:

  • Dr. Craig M. Crews is the John C. Malone Professor of Molecular, Cellular and Developmental Biology at Yale University. With a rich academic and biotech background, Dr. Crews has been a pioneer in using small molecules to control intracellular protein levels. His contributions have led to the development of innovative therapies, including the FDA-approved drug Kyprolis™ for the treatment of multiple myeloma. Dr. Crews’ commitment to advancing the field of chemical biology has earned him numerous awards and honors, including the Connecticut Medal of Technology in 2022.
  • Dr. Scott A. Holley, a Professor and Chair of the Department of Molecular, Cellular and Developmental Biology, specializes in systems developmental biology, biophysics, and biomechanics. His research focuses on early spinal column development in zebrafish, shedding light on the fundamental processes that shape vertebrate embryos.
  • Dr. Ling Chu, born and raised in China, has a diverse academic journey, from chemistry to chemical biology. After completing his Ph.D. at the Scripps Research Institute, he transitioned to chemical biology research at Yale School of Medicine, where he developed innovative tools for live-cell super-resolution imaging. Dr. Chu’s work has bridged the gap between chemistry and biology.
  • Miriam A. Genuth holds a BA from the University of Chicago and a Ph.D. from the University of California, San Francisco. Her research journey has led her to study chick cranial neural crest cell migration and zebrafish body elongation in the Holley lab at Yale, contributing to our understanding of developmental biology.
  • Elvira An, a graduate candidate in the Department of Pharmacology at Yale University, brings her background in mathematics and post-baccalaureate research experience to the lab of Craig Crews. Her research focuses on unraveling the mechanisms of chemically induced cell fate changes, a critical area in chemical biology.
  • Kusal T. G. Samarasinghe’s academic journey spans from Sri Lanka to the United States, culminating in his pivotal role in the development of OligoTRAFTACs. His work targets hard-to-drug transcription factors, expanding the druggable space within targeted protein degradation and pushing the boundaries of what’s possible in this field.

The RSC Chemical Biology Outstanding Paper 2022 Award not only celebrates the accomplishments of these exceptional researchers but also highlights the transformative potential of their work. We eagerly anticipate the impact of OligoTRAFTACs on the future of chemical biology and look forward to the insights that will be shared during the upcoming webinar series.

Congratulations to the winning team, and thank you for your invaluable contributions to the field of chemical biology!

 

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Professor Laura Kiessling joins the Advisory Board

25 Jul 2023

Welcome Prof Kiessling to RSC Chemical Biology!

 

 

We are delighted to welcome Prof Kiessling to the Advisory Board of RSC Chemical Biology.

Professor Kiessling received an Sc.B. degree in chemistry at MIT, where she performed undergraduate research in organic synthesis with Professor Bill Roush. She received a Ph.D. degree in chemistry at Yale University for her research with Stuart L. Schreiber. She was an American Cancer Society postdoctoral fellow with Peter B. Dervan at California Institute of Technology. She then joined the faculty at the University of Wisconsin–Madison, where she became the Steenbock Professor of Chemistry, the Laurens Anderson Professor of Biochemistry, and the Director of the Keck Center for Chemical Genomics. In 2017, she returned to MIT as the Novartis Professor of Chemistry.

Professor Kiessling is a member of the American Academy of Arts & Sciences, the American Academy of Microbiology, the American Philosophical Society, and National Academy of Sciences. She is the founding Editor-In-Chief of the journal ACS Chemical Biology . She is an author of over 140 peer-reviewed journal articles, and an inventor on more than 28 US patents. She has advised approximately 100 graduate students and postdoctorates. Alumni from her research group are contributing through their positions as faculty members of distinguished research universities, medical schools, and colleges and as research scientists at innovative start-up companies, leading corporations, and government laboratories.

 

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

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Welcome Lingyin Li to the Editorial Board!

24 Apr 2023

We are delighted to introduce Lingyin Li as an Associate Editor for RSC Chemical Biology!

 

Dr. Lingyin Li is an associate professor in the Biochemistry Department at Stanford School of Medicine. She is also a faculty fellow at the Sarafan ChEM-H Institute and a core investigator at the Arc Institute. She attended the University of Science and Technology of China, where she majored in Polymer Physics at the Chemistry and Chemical Engineering Institute, and earned a bachelor of engineering degree. Dr. Li obtained her Ph.D. in Chemistry from the University of Wisconsin-Madison under the mentorship of Dr. Laura Kiessling. She then sought her postdoctoral training in biochemistry and cancer immunology at Harvard Medical School with Dr. Tim Mitchison. Dr. Li joined the faculty at Stanford School of Medicine in 2015. Her lab has focused on the chemical biology of the cGAMP-STING pathway and harnessing it for the treatment of cancer and autoimmune diseases. Dr. Li has been honored with several prestigious awards including the C&En News Talented 12, NIH Director’s New Innovator Award, and Eli Lilly Award in Biological Chemistry.

 

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

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Introducing Jin Zhang to the team!

28 Feb 2023

We are delighted to introduce Jin Zhang as an Advisory board member for RSC Chemical Biology

 

Dr Jin Zhang received her PhD in Chemistry from University of Chicago in 2000.  After completing her postdoctoral work in the laboratory of Roger Tsien at UC San Diego, she joined the faculty of Johns Hopkins University School of Medicine in 2003. She was promoted to Professor of Pharmacology, Neuroscience and Chemical and Biomolecular Engineering in 2013. In 2015 she moved back to UC San Diego and is currently Professor and vice Chair in Department of Pharmacology. She is also a member of the Moores Cancer Centre and an Affiliate Professor in Departments of Bioengineering and Chemistry & Biochemistry at UC San Diego. She co-directs the Centre for Cell Signaling San Diego with Dr Alexandra Newton. Research in her lab focuses on developing enabling technologies to probe the active molecules in their native environment and characterizing how these active molecules change in diseases including cancer. Dr Zhang is a recipient of Biophysical Society Margaret Oakley Dayhoff Award (2009), NIH Director’s Pioneer Award (2009), John J. Abel Award in Pharmacology (2012), Pfizer Award in Enzyme Chemistry (2012), NCI Outstanding Investigator Award (2015 and 2022), Novartis Global Scholar Award (2021), Robert R. Ruffolo Career Achievement Award in Pharmacology (2022) and the Protein Society Christian B. Anfinsen Award (2022). She was elected as a Fellow of the American Association for the Advancement of Science (AAAS) in 2014, a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) in 2019 and a Fellow of American Society for Pharmacology and Experimental Therapeutics in 2021 (FASPET). Dr Zhang also received UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring in 2019 and Outstanding Graduate Student Mentoring Award in UC San Diego Jacobs School of Engineering in 2022. Dr Zhang will be receiving the Carolyn Cohen Innovation Award from the Biophysical Society in 2023.

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

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Upcoming conferences highlighted for RSC Chemical Biology readers! January 2023

20 Oct 2022

RSC Chemical Biology is highlighting some upcoming conferences in January 2023 that we think would be of interest to our broad chemical biology readership. We’re sponsoring these conferences and attending one too! Please consider registering!

3rd PSL Chemical Biology Symposium

12-13th Jan 2023
Paris, France
Registration deadline: 31st Oct 2022
Poster abstract deadline: 30th Nov 2022
RSC Chemical Biology will be attending this conference!

RSC Chemical Biology and Bio-organic Group Forum 2023

13th Jan 2023
Belfast, United Kingdom
Oral/poster abstract deadline: 11th Nov 2022
Registration deadline: 25th Nov 2022

Advances in Chemical Biology – DECHEMA

24-25 Jan 2023
Frankfurt, Germany
Poster abstract submission deadline: 31st Oct 2022
Last minute poster deadline: 6th Jan 2022

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RSC Desktop Seminar Series – The Interface of Chemistry & Biology

13 Oct 2022

 

We are delighted to introduce the latest series of Desktop Seminars on the Interface of Chemistry & Biology.

This exciting Series will feature talks from authors and Board Members from across the RSC’s publishing portfolio, including RSC Chemical Biology, RSC Advances, ChemComm, Chemical Science, and Molecular Omics.

Each session will include two talks from a range of international speakers highlighting their research in relation to the interface of chemistry and biology.

 

Save the dates and join us for these free virtual events: 

RSC Desktop Seminar with ChemComm – Register Here

Join us on Wednesday 26th October 2022, at 15:00 GMT / 10:00 EST

Featuring Prof. Mingxu You, University of Massachusetts Amherst, USA, and Prof. Amanda Hargrove, Duke University, USA

 

RSC Desktop Seminar with RSC Chemical Biology – Register Here

Join us on Friday 11th November 2022, at 14:00 GMT / 15:00 CET

Featuring Prof. Jennifer Andexer, University of Freiburg, Germany, and Prof. Roderich Suessmuth, TU Berlin, Germany

 

RSC Desktop Seminar with Chemical Science – Register Here

Join us on Thursday 17th November 2022, at 15:00 GMT / 10:00 EST

Featuring Prof. Gonçalo Bernardes, University of Cambridge, UK, and Prof. Dorothea Fiedler, Research Institute for Molecular Pharmacology (FMP) and Humboldt University of Berlin, Germany

 

RSC Desktop Seminar with RSC Advances – Register Here

Join us on Thursday 24th November 2022, at 11:00 GMT / 16:30 IST

Featuring Prof. Surajit Ghosh, Indian Institute of Technology Jodhpur, India, and Dr. Christine Beemelmanns, Hans-Knoll Institute, Germany

More dates to be announced soon!

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Call for papers – Chemical Biology of Metals

23 Aug 2022

A banner listing the details for the collection, including a dealdine of 6 March 2023, and a submission link rsc.li/rsc-chembio

RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Chemical Biology of Metals’, guest edited by Christopher J. Chang (University of California, Berkeley, USA); Angela Casini (Technical University of Munich, Germany); Hongzhe Sun (University of Hong Kong, China); and Hui Chao (Sun Yat-Sen University, China).

 Contributions are welcome which investigate the fundamental inorganic chemistry of life and/or use inorganic chemistry for medicine. New chemical methods for sensing and imaging, metalloproteomics, metal-based therapeutics and diagnostics, as well as structural and functional consequences of novel protein and nucleic acid metallobiochemistry in vitro and in living systems, are welcome for this themed collection on emerging topics in chemical biology of metals research.

 The deadline for submissions is 6 March 2023. Submit your work to the collection now!

Promotion of the collection is scheduled for mid-2023, with articles published online as soon as they’re accepted.

Authors are welcome to submit original research in the form of a Communication or Full Paper.  Articles can be submitted via our website: rsc.li/rsc-chembio. When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.

Explore all open calls for papers from RSC journals!

About RSC Chemical Biology:

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Articles accepted for publication in this themed collection will have their article processing charges waived.

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio.

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Themed collection on “Synthesis and chemical biology of macrocycles”

08 Aug 2022

We’re pleased to announce that our first guest-edited themed collection, on the Synthesis and Chemical Biology of Macrocycles, has now been published online! We thank the Guest Editors, Gong Chen (Nankai University), Monika Raj (Emory University), and Andrei Yudin (University of Toronto) for their work editing this collection.

Read the collection

Macrocycles are an important class of compounds with a long-recognised, significant role in chemical biology and drug discovery. This themed collection offers a collection of articles that showcase the ongoing interest in the chemical biology of macrocycles. Recent years have witnessed the development of new synthetic and biological strategies to construct large rings composed of amino acid residues. In addition, significant progress has been made in efforts to understand and predict the properties of macrocycles. We have collected contributions that are representative of the tremendous promise and pace of growth in this area.

The work in this collection covers all areas of the synthesis and chemical biology of macrocycles, including new synthetic and biosynthetic pathways for synthesis of diverse range of macrocycles; peptide and peptidomimetics macrocycles; design and synthesis of macrocycles for biological and medicinal applications; cell permeable macrocycles for targeting intracellular proteins; structural studies of macrocycles to expand the conformational drug space, and much more. Taken together, the papers collected in this themed collection represent the state of the art in macrocycles and highlight work at the interface of chemistry and biology.

Editorial

Introduction to ‘Synthesis and chemical biology of macrocycles’
RSC Chem. Biol., 2022, 3, 993-993. DOI: 10.1039/D2CB90018A

Reviews

Peptide/protein-based macrocycles: from biological synthesis to biomedical applications
Wen-Hao Wu, Jianwen Guo, Longshuai Zhang, Wen-Bin Zhang and Weiping Gao
RSC Chem. Biol., 2022, 3, 815-829. DOI: 10.1039/D1CB00246E

Cyclic peptide drugs approved in the last two decades (2001–2021)
Huiya Zhanga and Shiyu Chen
RSC Chem. Biol., 2022, 3, 18-31. DOI: 10.1039/D1CB00154J

Communication

Targeted disruption of PKC from AKAP signaling complexes
Ameya J. Limaye, George N. Bendzunasa and Eileen J. Kennedy
RSC Chem. Biol., 2021, 2, 1227-1231. DOI: 10.1039/D1CB00106J

Papers

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake
Aline D. de Araujo, Junxian Lim, Kai-Chen Wu, Huy N. Hoang, Huy T. Nguyen and David P. Fairlie
RSC Chem. Biol., 2022, 3, 895-904. DOI: 10.1039/D1CB00231G

Navigating complex peptide structures using macrocycle conformational maps
Timothy J. McTiernan, Diego B. Diaz, George J. Saunders, Fiona Spranga and Andrei K. Yudin
RSC Chem. Biol., 2022, 3, 739-747. DOI: 10.1039/D2CB00016D

Structural impact of thioamide incorporation into a β-hairpin
Kristen E. Fiore, Martijn J. Patist, Sam Giannakoulias, Cheng-Hsin Huang, Hitesh Verma, Bhavesh Khatri, Richard P. Cheng, Jayanta Chatterjee and E. James Petersson
RSC Chem. Biol., 2022, 3, 582-591. DOI: 10.1039/D1CB00229E

Synthesis of medium-ring lactams and macrocyclic peptide mimetics via conjugate addition/ring expansion cascade reactions
Kleopas Y. Palate, Zhongzhen Yang, Adrian C. Whitwood and William P. Unsworth
RSC Chem. Biol., 2022, 3, 334-340. DOI: 10.1039/D1CB00245G

Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue
Masanobu Nagano, Satoshi Ishida and Hiroaki Suga
RSC Chem. Biol., 2022, 3, 295-300. DOI: 10.1039/D1CB00225B

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Anselm F. L. Schneider, Joerg Kallen, Johannes Ottl, Patrick C. Reid, Sebastien Ripoche, Stephan Ruetz, Therese-Marie Stachyra, Samuel Hintermann, Christoph E. Dumelin, Christian P. R. Hackenberger and Andreas L. Marzinzik
RSC Chem. Biol., 2021, 2, 1661-1668. DOI: 10.1039/D1CB00056J

Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain
Ilona Christy Unarta, Jianchao Xu, Yuan Shang, Carina Hey Pui Cheung, Ruichi Zhu, Xudong Chen, Siqin Cao, Peter Pak-Hang Cheung, Donald Bierer, Mingjie Zhang, Xuhui Huang and Xuechen Li
RSC Chem. Biol., 2021, 2, 1274-1284. DOI: 10.1039/D1CB00087J

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Tri-Institutional Chemical Biology Symposium

07 Aug 2020

RSC Chemical Biology is proud to be sponsoring the 16th Annual Tri-Institutional Chemical Biology Symposium, which will take place virtually on the 1st of September, 2020, 09:00-18:30 EDT.

This event showcases research at the forefront of chemical biology, and is sponsored and organized by the Tri-Institutional PhD Program in Chemical Biology (TPCB), a joint graduate program of Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medicine in New York City.

Register for this free event here by the 28th of August 2020

Undergraduate students interested in chemical biology are especially encouraged to attend.

Poster submissions are welcomed from all attendees, including early college high school students, undergraduates, postbaccalaureate students, research assistants and technicians, graduate students, postdoctoral fellows, research staff, and faculty. Posters will be presented live by video in parallel meeting rooms, and judged by TPCB faculty members and keynote speakers for a selection of poster awards sponsored by TPCB and their promotional partners, including RSC Chemical Biology, Chemical Science and Organic & Biomolecular Chemistry.

For more information, please visit the Tri-Institutional Chemical Biology Symposium event page.

TPCB has been strongly committed to diversity and inclusion since its inception. It welcomes scientists from underrepresented minority groups and disadvantaged backgrounds, and those with disabilities.  It does not tolerate racism, discrimination, or harassment of any kind. All attendees are expected to maintain the highest standards of professional conduct throughout the symposium.

 

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