Archive for the ‘Uncategorized’ Category

Upcoming conferences highlighted for RSC Chemical Biology readers! January 2023

RSC Chemical Biology is highlighting some upcoming conferences in January 2023 that we think would be of interest to our broad chemical biology readership. We’re sponsoring these conferences and attending one too! Please consider registering!

3rd PSL Chemical Biology Symposium

12-13th Jan 2023
Paris, France
Registration deadline: 31st Oct 2022
Poster abstract deadline: 30th Nov 2022
RSC Chemical Biology will be attending this conference!

RSC Chemical Biology and Bio-organic Group Forum 2023

13th Jan 2023
Belfast, United Kingdom
Oral/poster abstract deadline: 11th Nov 2022
Registration deadline: 25th Nov 2022

Advances in Chemical Biology – DECHEMA

24-25 Jan 2023
Frankfurt, Germany
Poster abstract submission deadline: 31st Oct 2022
Last minute poster deadline: 6th Jan 2022

RSC Desktop Seminar Series – The Interface of Chemistry & Biology

 

We are delighted to introduce the latest series of Desktop Seminars on the Interface of Chemistry & Biology.

This exciting Series will feature talks from authors and Board Members from across the RSC’s publishing portfolio, including RSC Chemical Biology, RSC Advances, ChemComm, Chemical Science, and Molecular Omics.

Each session will include two talks from a range of international speakers highlighting their research in relation to the interface of chemistry and biology.

 

Save the dates and join us for these free virtual events: 

RSC Desktop Seminar with ChemCommRegister Here

Join us on Wednesday 26th October 2022, at 15:00 GMT / 10:00 EST

Featuring Prof. Mingxu You, University of Massachusetts Amherst, USA, and Prof. Amanda Hargrove, Duke University, USA

 

RSC Desktop Seminar with RSC Chemical Biology – Register Here

Join us on Friday 11th November 2022, at 14:00 GMT / 15:00 CET

Featuring Prof. Jennifer Andexer, University of Freiburg, Germany, and Prof. Roderich Suessmuth, TU Berlin, Germany

 

RSC Desktop Seminar with Chemical ScienceRegister Here

Join us on Thursday 17th November 2022, at 15:00 GMT / 10:00 EST

Featuring Prof. Gonçalo Bernardes, University of Cambridge, UK, and Prof. Dorothea Fiedler, Research Institute for Molecular Pharmacology (FMP) and Humboldt University of Berlin, Germany

 

RSC Desktop Seminar with RSC AdvancesRegister Here

Join us on Thursday 24th November 2022, at 11:00 GMT / 16:30 IST

Featuring Prof. Surajit Ghosh, Indian Institute of Technology Jodhpur, India, and Dr. Christine Beemelmanns, Hans-Knoll Institute, Germany

More dates to be announced soon!

Call for papers – Chemical Biology of Metals

A banner listing the details for the collection, including a dealdine of 6 March 2023, and a submission link rsc.li/rsc-chembio

RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Chemical Biology of Metals’, guest edited by Christopher J. Chang (University of California, Berkeley, USA); Angela Casini (Technical University of Munich, Germany); Hongzhe Sun (University of Hong Kong, China); and Hui Chao (Sun Yat-Sen University, China).

 Contributions are welcome which investigate the fundamental inorganic chemistry of life and/or use inorganic chemistry for medicine. New chemical methods for sensing and imaging, metalloproteomics, metal-based therapeutics and diagnostics, as well as structural and functional consequences of novel protein and nucleic acid metallobiochemistry in vitro and in living systems, are welcome for this themed collection on emerging topics in chemical biology of metals research.

 The deadline for submissions is 6 March 2023. Submit your work to the collection now!

Promotion of the collection is scheduled for mid-2023, with articles published online as soon as they’re accepted.

Authors are welcome to submit original research in the form of a Communication or Full Paper.  Articles can be submitted via our website: rsc.li/rsc-chembio. When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.

Explore all open calls for papers from RSC journals!

About RSC Chemical Biology:

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Articles accepted for publication in this themed collection will have their article processing charges waived.

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio.

Themed collection on “Synthesis and chemical biology of macrocycles”

We’re pleased to announce that our first guest-edited themed collection, on the Synthesis and Chemical Biology of Macrocycles, has now been published online! We thank the Guest Editors, Gong Chen (Nankai University), Monika Raj (Emory University), and Andrei Yudin (University of Toronto) for their work editing this collection.

Read the collection

Macrocycles are an important class of compounds with a long-recognised, significant role in chemical biology and drug discovery. This themed collection offers a collection of articles that showcase the ongoing interest in the chemical biology of macrocycles. Recent years have witnessed the development of new synthetic and biological strategies to construct large rings composed of amino acid residues. In addition, significant progress has been made in efforts to understand and predict the properties of macrocycles. We have collected contributions that are representative of the tremendous promise and pace of growth in this area.

The work in this collection covers all areas of the synthesis and chemical biology of macrocycles, including new synthetic and biosynthetic pathways for synthesis of diverse range of macrocycles; peptide and peptidomimetics macrocycles; design and synthesis of macrocycles for biological and medicinal applications; cell permeable macrocycles for targeting intracellular proteins; structural studies of macrocycles to expand the conformational drug space, and much more. Taken together, the papers collected in this themed collection represent the state of the art in macrocycles and highlight work at the interface of chemistry and biology.

Editorial

Introduction to ‘Synthesis and chemical biology of macrocycles’
RSC Chem. Biol., 2022, 3, 993-993. DOI: 10.1039/D2CB90018A

Reviews

Peptide/protein-based macrocycles: from biological synthesis to biomedical applications
Wen-Hao Wu, Jianwen Guo, Longshuai Zhang, Wen-Bin Zhang and Weiping Gao
RSC Chem. Biol., 2022, 3, 815-829. DOI: 10.1039/D1CB00246E

Cyclic peptide drugs approved in the last two decades (2001–2021)
Huiya Zhanga and Shiyu Chen
RSC Chem. Biol., 2022, 3, 18-31. DOI: 10.1039/D1CB00154J

Communication

Targeted disruption of PKC from AKAP signaling complexes
Ameya J. Limaye, George N. Bendzunasa and Eileen J. Kennedy
RSC Chem. Biol., 2021, 2, 1227-1231. DOI: 10.1039/D1CB00106J

Papers

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake
Aline D. de Araujo, Junxian Lim, Kai-Chen Wu, Huy N. Hoang, Huy T. Nguyen and David P. Fairlie
RSC Chem. Biol., 2022, 3, 895-904. DOI: 10.1039/D1CB00231G

Navigating complex peptide structures using macrocycle conformational maps
Timothy J. McTiernan, Diego B. Diaz, George J. Saunders, Fiona Spranga and Andrei K. Yudin
RSC Chem. Biol., 2022, 3, 739-747. DOI: 10.1039/D2CB00016D

Structural impact of thioamide incorporation into a β-hairpin
Kristen E. Fiore, Martijn J. Patist, Sam Giannakoulias, Cheng-Hsin Huang, Hitesh Verma, Bhavesh Khatri, Richard P. Cheng, Jayanta Chatterjee and E. James Petersson
RSC Chem. Biol., 2022, 3, 582-591. DOI: 10.1039/D1CB00229E

Synthesis of medium-ring lactams and macrocyclic peptide mimetics via conjugate addition/ring expansion cascade reactions
Kleopas Y. Palate, Zhongzhen Yang, Adrian C. Whitwood and William P. Unsworth
RSC Chem. Biol., 2022, 3, 334-340. DOI: 10.1039/D1CB00245G

Inner residues of macrothiolactone in autoinducer peptides I/IV circumvent spontaneous S-to-O acyl transfer to the upstream serine residue
Masanobu Nagano, Satoshi Ishida and Hiroaki Suga
RSC Chem. Biol., 2022, 3, 295-300. DOI: 10.1039/D1CB00225B

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors
Anselm F. L. Schneider, Joerg Kallen, Johannes Ottl, Patrick C. Reid, Sebastien Ripoche, Stephan Ruetz, Therese-Marie Stachyra, Samuel Hintermann, Christoph E. Dumelin, Christian P. R. Hackenberger and Andreas L. Marzinzik
RSC Chem. Biol., 2021, 2, 1661-1668. DOI: 10.1039/D1CB00056J

Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain
Ilona Christy Unarta, Jianchao Xu, Yuan Shang, Carina Hey Pui Cheung, Ruichi Zhu, Xudong Chen, Siqin Cao, Peter Pak-Hang Cheung, Donald Bierer, Mingjie Zhang, Xuhui Huang and Xuechen Li
RSC Chem. Biol., 2021, 2, 1274-1284. DOI: 10.1039/D1CB00087J

Tri-Institutional Chemical Biology Symposium

RSC Chemical Biology is proud to be sponsoring the 16th Annual Tri-Institutional Chemical Biology Symposium, which will take place virtually on the 1st of September, 2020, 09:00-18:30 EDT.

This event showcases research at the forefront of chemical biology, and is sponsored and organized by the Tri-Institutional PhD Program in Chemical Biology (TPCB), a joint graduate program of Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medicine in New York City.

Register for this free event here by the 28th of August 2020

Undergraduate students interested in chemical biology are especially encouraged to attend.

Poster submissions are welcomed from all attendees, including early college high school students, undergraduates, postbaccalaureate students, research assistants and technicians, graduate students, postdoctoral fellows, research staff, and faculty. Posters will be presented live by video in parallel meeting rooms, and judged by TPCB faculty members and keynote speakers for a selection of poster awards sponsored by TPCB and their promotional partners, including RSC Chemical Biology, Chemical Science and Organic & Biomolecular Chemistry.

For more information, please visit the Tri-Institutional Chemical Biology Symposium event page.

TPCB has been strongly committed to diversity and inclusion since its inception. It welcomes scientists from underrepresented minority groups and disadvantaged backgrounds, and those with disabilities.  It does not tolerate racism, discrimination, or harassment of any kind. All attendees are expected to maintain the highest standards of professional conduct throughout the symposium.