RSC Chemical Biology Blog

We invite you to read our new themed collection on Endocytosis and Cellular Delivery in RSC Chemical Biology and RSC Pharmaceutics.

Guest Edited by Prof. Alexander Kros (Leiden University), Prof. Vince Rotello (University of Massachusetts) and Prof. Georgina Such (University of Melbourne), this collection explores how both biological and synthetic tools can be leveraged to understand the impact of material structure on the migration of specific cellular barriers, aiming to enhance the delivery efficiency of macromolecules and delivery systems such as liposomes, lipid nanoparticles, and polymeric carriers.

Read the collection

The article line-up has been provided below. All articles in RSC Chemical Biology and RSC Pharmaceutics are open access and free to read

Editorial

Introduction to “Endocytosis and cellular delivery”

Alexander A. Kros, Georgina Such, and Vincent M. Rotello

RSC. Chem. Biol., 2026, DOI: 10.1039/D6CB90009G

Reviews

Breaking the cellular delivery bottleneck: recent developments in direct cytosolic delivery of biologics

Harini Nagaraj, Victor Lehot, Nourina Nasim, Yagiz Anil Cicek, Ritabrita Goswami, Taewon Jeon and Vincent M. Rotello

RSC. Pharm., 2025, 2, 850–864, DOI: 10.1039/D5PM00129C

A new strategy for the extrahepatic delivery of lipid-based nanomedicines: a protein corona-mediated selective targeting system based on an ionizable cationic lipid library

Mahmoud A. Younis, Yusuke Sato, Seigo Kimura and Hideyoshi Harashima

RSC. Pharm., 2025, 2, 982–1002, DOI: 10.1039/D5PM00079C

Papers and Communications

trans-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity

Amber Barendrecht, Heleen H. C. Peeters, Diana Torres-García, M. Thierry Shema, Alexi J. C. Sarris, Shimrit David, Göktuğ Aba, Camille M. Le Gall, Martin Wilkovitsch, Martijn Verdoes, Hannes Mikula, Mark A. Travis and Sander I. van Kasteren

RSC. Chem. Biol., 2025, 6, 1068–1078, DOI: 10.1039/D5CB00113G

Rapid plasma membrane reorganisation and endocytosis in HER2 breast cancer cells incubated with trastuzumab decorated polymer nanoparticles

Carwyn S. Hughes, Saeed Tayeb, Duncan Muir, Anthony J. Hayes, Peter Watson and Arwyn T. Jones

RSC. Pharm., 2026, DOI: 10.1039/D5PM00168D

Effect of shape on cellular internalization and anti-cancer efficacy of hydroxyapatite nanoparticles in an osteosarcoma cell line

Simmi Gupta, Esha S. Attar, Vishvesh Joshi and Padma V. Devarajan

RSC. Pharm., 2025, 6, 1087–1095, DOI: 10.1039/D5CB00005J

We hope you enjoy this new themed collection.