Biomaterials Science Blog

A cancer treatment that goes further

10 Oct 2012

A cancer treatment that uses titanium dioxide nanoparticles to kill tumour cells has been given a sound revamping by researchers in Japan. The new strategy improves the stability of the nanoparticles and the treatment may be able to penetrate more deeply into human tissues than ever before, targeting problematic tumours, through the use of ultrasound.

Atsushi Harada and colleagues at Osaka Prefecture University encapsulated the titanium dioxide nanoparticles inside micelles (an aggregate of surfactant molecules dispersed in a liquid colloid). The team grafted polyethylene glycol, a polymer with many medical uses, onto the micelles to stabilise them, improve their biocompatibility and to ensure that the micelles had negligible cytotoxicity. ‘Low cytotoxicity is the most important property of our micellar system’ Harada explains.

Titanium dioxide nanoparticle-entrapped micelles can selectively kill cells at only the ultrasound-irradiated area

Read the full article at Chemistry World.

Titanium dioxide nanoparticle-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy
Atsushi Harada, Masafumi Ono, Eiji Yuba and Kenji Kono
Biomater. Sci., 2013, Advance Article
DOI: 10.1039/C2BM00066K

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Profile of the Institute for Integrated Cell-Material Sciences

05 Oct 2012

By Sam Keltie, Executive Editor.

Now that we have published our first few articles, I thought this might be a good time to tell you a little more about the Institute for Integrated Cell-Material Sciences (WPI-iCeMS). Biomaterials Science is a collaborative venture between RSC Publishing and the iCeMS, which is based at Kyoto University, Japan.

The iCeMS is part of the Japanese government’s World Premier International Research Center (WPI) Initiative, launched in 2007 to forge a new model for scientific institutions, helping Japan lead the world in a broad range of leading-edge research. By merging materials science and cell biology, both fields of great strength at Kyoto University, the iCeMS is creating a new cross-discipline, supported by an advanced research environment and infrastructure that are unprecedented in Japan. The institute’s focus is on two main areas: stem cell science & technology and mesoscopic science & technology. The institute’s work draws from the life sciences, chemistry, materials science, as well as physics, constantly expanding the boundaries of technological innovation.

To find out more visit: www.icems.kyoto-u.ac.jp or www.facebook.com/Kyoto.Univ.iCeMS.

Biomaterials Science is now accepting submissions. All articles will be free to access until the end of 2014. Please contact the editorial office if you have any questions about the journal.

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If you want to find out about the first articles once they’re published online why not sign up for the Biomaterials Science RSS feed or Table of Contents alert.

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Accepted Manuscript option is now available for Biomaterials Science

04 Oct 2012

By Sam Keltie, Executive Editor.

Did you know that you can now choose for your Biomaterials Science manuscript to be published as an Accepted Manuscript.

An Accepted Manuscript is an unedited and unformatted version of an article that is published shortly after acceptance. This free service allows authors to make their results available to the community, in citable form, before publication of the edited article. It is available as a downloadable PDF file. It is then replaced by the fully edited and formatted Advance Article.

For more information please read our dedicated webpage.

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Biomaterials Science – new Advanced Articles

26 Sep 2012

By Sam Keltie, Executive Editor.

Understanding the role of nano-topography on the surface of a bone-implant

This review by Walboomers and co-authors discusses the interaction of cells with the nano-topographical features of bone implants. The review also details the characterisation of implant surfaces and their manufacture.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00032f, Advance article)

Titanium dioxide nanoparticle-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy

The main cytotoxic agent in photodynamic therapy is believed to be the reactive oxygen species ¹O₂ which is used to treat cancerous diseases. In this paper, Harada and co-workers investigate the generation of reactive oxygen species using sonication of TiO₂ nanoparticles. They first synthesised TiO₂ nanoparticle-entrapped micelles with a core-shell structure. The nanoparticles were able to generate reactive oxygen species by sonication when inside the micelles. The frequently of sonication was appropriate for clinical situations, thus they has the potential to be used in sonodynamic therapy.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00066k, Advance article)

A progressive approach on inactivation of bacteria using silver–titania nanoparticles

The antibacterial properties of silver compounds have long been known. In this paper by Li, Luo and Bashir, Ag-decorated TiO₂ nanoparticles were prepared by a colloidal chemistry method. The nanoparticles were coincubated with model microbes, that are found in water, to investigate their biocidal effectiveness. The bactericidal mechanism was also investigated with a focus on the role of the microbial outer membrane.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00010e, Advance article)

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Mesoscale esplained: Editorial by Norio Nakatsuji

21 Sep 2012

By Sam Keltie, Executive Editor.

Editorial by Co-Editor and Editor-in-Chief to be published in Issue 1 of Biomaterials science

An Editorial by Norio Nakatsuji (Director WPI-iCeMS) is now published. The Editorial explains that the mesoscopic domain exists between the nano-space and the bulk space, the scale between nanometers and micrometers. It goes on to say that understanding processes that occur in the mesoscopic domain will lead to breakthroughs in biomaterials science and biotechnology.

Biomater. Sci., 2012, DOI: 10.1039/c2bm90001g, Advance article

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The first advance articles for Biomaterials Science have been published!

21 Sep 2012

By Sam Keltie, Executive Editor.

All Biomaterials Science content is free for 2 years!

Mesoporous silica nanoparticles for the design of smart delivery nanodevices

The nanomedical use of mesoporous silica nanoparticles has the potential to be revolutionary. This review by María Vallet-Regí and co-workers focuses on the design of mesoporous silica nanoparticles as smart drug delivery systems. The review also covers stimuli-responsive nanocaps and magnetic nanoparticles.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00085g, Advance article)

Enzyme responsive materials: design strategies and future developments

Enzyme responsive materials are discussed in this review by Rein V. Ulijn and co-authors. Several strategies for the development of the materials are described such as polymer hydrogels, supramolecular materials and quantum dot particles. The review also discusses the challenges in the development of these materials for specific applications.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00041e, Advance article)

Citrate-based biodegradable injectable hydrogel composites for orthopaedic applications

Bone biomaterials and scaffolds that have excellent in vivo responses and properties have been a much researched topic over the last 20 years. In this paper by Jian Yang and co-workers, a new bioactive citrate-based injectable biodegradable composite is developed. The composite consists of poly (ethylene glycol) (a FDA approved polymer) and hydroxyapatite which is used for delivering cells into irregular bony defects.

(Biomater. Sci., 2012, DOI: 10.1039/c2bm00026a, Advance article)

Don’t forget to keep up-to-date with all the latest research you can sign-up for the Biomaterials Science RSS feed or Table of contents alert.

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Congratulations to the Biomaterials Science Poster Prize winner at NanoBio 2012

13 Aug 2012

By Russell Johnson, Development Editor.

Congratulations to Jinzi Zheng from the Princess Margaret Hospital, Toronto, Canada, who won the Biomaterials Science poster prize at the recent NanoBio 2012 conference in Seattle, USA.

Jinzi Zheng’s winning poster was titled “PET/CT Imaging of the Heterogeneous Distribution of [64Cu]-Iodine Liposomes in Orthotopic Mouse Cervical Tumors”.

NanoBio 2012 was held 23^rd – 26^th July 2012.

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Biomaterials Science featured in Kagaku Chemistry

08 Aug 2012

By Russell Johnson, Development Editor.

Biomaterials Science has been featured in the Japanese magazine Kagaku Chemistry. If you’re not familiar with it its described as “One of the most widely read monthly magazines in Japan. With sound popularity among students, researchers and engineers of chemistry for over 40 years, “Kagaku”(Chemistry) has been addressing topics on chemistry and related fields from a unique viewpoint. Bearing the slogan ‘Quality content with comprehensible description’, it not only introduces cutting-edge studies, but also tackles environmental issues, chemical education and science policies, while gaining a high reputation as one of the most inspiring magazines in chemistry”

(If you click on the images you should be able to zoom in and see the text clearly.)

Biomaterials Science is now accepting submissions. All articles will be free to access until the end of 2014. Please contact the editorial office if you have any questions about the journal.

Don’t forget you can Like us on Facebook or Follow us on Twitter to keep up with the latest news.

If you want to find out about the first articles once they’re published online why not sign up for the Biomaterials Science RSS feed or Table of Contents alert.

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Reviews on biomaterials and the materials-bio interface – Free until 3rd September

06 Aug 2012

By Russell Johnson, Development Editor.

I’ve been having a look at some of the reviews we’ve published in the RSC materials journals and thinking about why we publish review articles. Journals publish different types of reviews. Many are in-depth critical overviews of a topic, others act as tutorials for people moving into a new areas or learning new techniques, some focus specifically on applications or highlight just the most important developments over the last couple of years. I’d be interested to hear what you think makes up a good review. For our part we see reviews as an integral part of our journals and we hope they provide a great overview of the latest trends, opinion, and groundbreaking research for our readers. If you’re interested Biomaterials Science will publish just two broad types of review: reviews and mini-reviews.

Below I’ve gathered together a selection of reviews on biomaterials and materials interfacing with biology. Hopefully this will give you a flavour of the reviews published by RSC journals in this area. The articles are all free to download until 3^rd September. I hope you enjoy reading them.

Feature Article
Interactions of cells with silk surfaces
Aldo Leal-Egaña and Thomas Scheibel
J. Mater. Chem., 2012, 22, 14330-14336

Frontier
Microengineered physiological biomimicry: Organs-on-Chips
Dongeun Huh , Yu-suke Torisawa , Geraldine A. Hamilton , Hyun Jung Kim and Donald E. Ingber
Lab Chip, 2012, 12, 2156-2164

Critical Reviews
Designer nanomaterials using chiral self-assembling peptide systems and their emerging benefit for society
Zhongli Luo and Shuguang Zhang
Chem. Soc. Rev., 2012, 41, 4736-4754

Click here to expand the list of reviews

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Biomaterials Science Blog

More advance articles published

A cancer treatment that goes further

Profile of the Institute for Integrated Cell-Material Sciences

Accepted Manuscript option is now available for Biomaterials Science

Biomaterials Science – new Advanced Articles

Mesoscale esplained: Editorial by Norio Nakatsuji

The first advance articles for Biomaterials Science have been published!

Congratulations to the Biomaterials Science Poster Prize winner at NanoBio 2012

Biomaterials Science featured in Kagaku Chemistry

Reviews on biomaterials and the materials-bio interface – Free until 3rd September

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