Archive for May, 2018

2018 Biomaterials Science Lectureship

Professor Zhen GuThe Biomaterials Science Lectureship is an annual award that honours an early-career researcher for their significant contribution to the biomaterials field. The recipient is selected by the Biomaterials Science Editorial Board from a list of candidates nominated by the community.

This year we are delighted to award the Lectureship to Professor Zhen Gu (University of North Carolina at Chapel Hill and North Carolina State University). He will present the Biomaterials Science lecture and receive his award at the European Society for Biomaterials Annual Meeting in Maastricht in September 2018.

Prof. Zhen Gu received his B.S. degree in Chemistry and M.S. degree in Polymer Chemistry and Physics from Nanjing University. In 2010, he obtained Ph.D. at the University of California, Los Angeles, under the guidance of Prof. Yi Tang in the Department of Chemical and Biomolecular Engineering. He was a Postdoctoral Associate working with Profs. Robert Langer and Daniel Anderson at MIT and Harvard Medical School during 2010 to 2012.

Prof. Zhen Gu is the recipient of the Young Investigator Award of the Controlled Release Society (CRS, 2017), Sloan Research Fellowship (2016), Pathway Award of the American Diabetes Association (ADA, 2015) and Young Innovator Award in Cellular and Molecular Engineering of the Biomedical Engineering Society (BMES, 2015). MIT Technology Review listed him in 2015 as one of the global top innovators under the age of 35 (TR35).

His group studies controlled drug delivery, bio-inspired materials and nanobiotechnology, especially for cancer and diabetes treatment.

To learn more about Zhen’s research, have a look at his recent publications in Biomaterials Science and our sister journals:

Engineering DNA scaffolds for delivery of anticancer therapeutics
Wujin Sun  and  Zhen Gu
Biomater. Sci., 2015,3, 1018-1024, Minireview

Advances in liquid metals for biomedical applications
Junjie Yan,  Yue Lu,  Guojun Chen,  Min Yang  and  Zhen Gu
Chem. Soc. Rev., 2018,47, 2518-2533, Tutorial Review

Investigation and intervention of autophagy to guide cancer treatment with nanogels
Xudong Zhang,  Xin Liang,  Jianjun Gu,  Danfeng Chang,b  Jinxie Zhang,  Zhaowei Chen,  Yanqi Ye,  Chao Wang,  Wei Tao,  Xiaowei Zeng,  Gan Liu,  Yongjun Zhang,  Lin Mei  and  Zhen Gu
Nanoscale, 2017,9, 150-163, Paper

Internalized compartments encapsulated nanogels for targeted drug delivery
Jicheng Yu,  Yuqi Zhang,  Wujin Sun,  Chao Wang,  Davis Ranson,  Yanqi Ye,  Yuyan Weng  and  Zhen Gu
Nanoscale, 2016,8, 9178-9184, Paper

Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery
Yue Lu,  Ran Mo,  Wanyi Tai,  Wujin Sun,  Dennis B. Pacardo,  Chenggen Qian,  Qundong Shen,  Frances S. Ligler  and  Zhen Gu
Chem. Commun., 2014,50, 15105-15108, Communication

Please join us in congratulating Zhen on his award!

 

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Cancer theranostics applications of Graphene Oxides

Graphene oxide (GO) has actively been used in various biomedical applications, including biomedical sensors, electronic sensors, functional composites and so on. In addition to having a large surface area, large-scale manufacturability and being dispersible in water, GO shows strong fluorescence and conjugation properties, owing to the abundance of oxygen functional groups on its surface.

Numerous methods have been developed to enable photon emission from GO sheets, such as reduction, labeling with fluorescent protein, and cleaving GO sheets into smaller fragments to produce graphene quantum dots (QDs), although this method does remove oxygen from the carbon lattice. This is a problem because reducing the oxygen content prevents the further functionalization of GO structures with biomolecules. Furthermore, such methods have been reported to cause cytotoxicity.

Cancer theranostics applications of Graphene Oxides

In this work by the Chen and co-workers, a blue fluorescence was induced in a GO suspension by triggering a phase transformation in GO through treatment with a simple, one-step mild annealing. Previously, it had been difficult to facilitate light emission from GO while preserving the oxygen content and maintaining low cytotoxicity. However, this work suggests that by providing a nano-bio interface for reactions with biomolecules the physical difficulties can be overcome. In this case, GO acts as a bio-imaging agent as well as a functionalization platform for biomolecules. Material characterization and biocompatibility tests were performed to examine the purity, inherent property and non-toxicity of the system. The mechanism for enhanced blue fluorescence upon mild annealing was discovered and modeled through atomistic simulations. Most importantly, GO shows an appealing capability in drug delivery and cellular imaging simultaneously. Overall, this method is expected to be inexpensive, rapid and straightforward, thus holding promise for the development of a whole new class of GO-based nanomaterials for cancer theranostics application in near future.

 

This article is free to read until 30 May

 

Simultaneous drug delivery and cellular imaging using graphene oxide Biomater. Sci., 2018, 6, 813-819

 

About the webwriter

Dr. Sudip MukherjeeDr. Sudip Mukherjee is a Web Writer for Biomaterials Science. He is currently a Postdoctoral Research Associate at the Rice University. His research is involved in the development of advanced nanomaterials for drug/gene delivery in cancer theranostics, immunomodulatory applications & angiogenesis. He published a total of ~30 research articles/patents. He serves as International Advisory Board Member for ‘Materials Research Express‘, IOP Sciences. He is an associate member (AMRSC) of RSC, UK. He serves as reviewer for several international journals like Chem Comm, J Mater Chem A, J Mater Chem B, Journal of Biomedical Nanotechnology, RSC Advances, IOP Nanotechnology etc.

Contact Email: sudip.mukherjee@rice.edu

Twitter: https://twitter.com/sudip_88

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