DNA nanotechnology allows the construction of self-assembled scaffolds for use in the arrangement of functional molecules and nanomaterials. These can be used to create complex molecular devices. DNA origami is a new programmed DNA assembly system that enables the design of 2D nanostructures which can be functionalised with molecules and nanoparticles.
This Review by Endo, Yang and Sugiyama covers the rapidly moving field of DNA materials science. The review describes the state of current DNA origami research and describes its applications in biomaterials such as the selective functionalisation and single molecule imaging of biomolecules; cell-targeting and as a basis for molecular machines.
DNA origami technology for biomaterials applications
Biomater. Sci., 2012, Advance Article. DOI: 10.1039/c2bm00154c